New bioactive monoterpene glycosides from paeoniae radix.

Murakami, Nobutoshi; Saka, M.; Shimada, Hiromi; Matsuda, Hisashi; Yamahara, Johji; Yoshikawa, Masayuki

doi:10.1248/cpb.44.1279

Cited by 57 publications

(31 citation statements)

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“…The detailed analysis of the NMR data (Table, Fig. ) revealed that the signals of 1 were very similar to those of 1-O-b-d-glucopyranosylpaeonisuffrone [8] [9], and that it contained a monoterpenoid bearing glucose and benzoyl moieties in its structure. To determine the absolute configuration of 1, a deacylation experiment was performed.…”

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confidence: 93%

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A New Monoterpene Glucoside from the Roots of Paeonia lactiflora

Kim¹,

Yean²,

Lee³

et al. 2008

Helvetica Chimica Acta

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. As part of our efforts to isolate the chemical constituents of P. lactiflora for the purpose of its standardization, we isolated a number of major and minor constituents from a P. lactiflora extract. In the present investigation, we report the isolation and structure elucidation of the new minor compound 1, together with two known compounds, 1-O-b-d-glucopyranosylpaeonisuffrone and paeonidanin 1 ) (2) from P. lactiflora.

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confidence: 93%

“…column chromatography over silica gel and RP-18 gel to yield the new monoterpene glucoside 1, together with two known compounds, paeonidanin (2) [6] [7] and 1-O-b-dglucopyranosylpaeonisuffrone [8] [9].…”

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confidence: 99%

A New Monoterpene Glucoside from the Roots of Paeonia lactiflora

Kim¹,

Yean²,

Lee³

et al. 2008

Helvetica Chimica Acta

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“…Paeoniae Radix is one of the most important natural medicines, and is prescribed in various Chinese medicinal preparations as an anodyne, sedative, antispasmodic and astringent. 1 Chemical studies on this natural medicine carried out by many investigators have revealed various constituents, represented by monoterpenes and monoterpene glycosides, such as paeonol, paeoniflorin and their derivatives. They are the principal constituents of Paeoniae Radix.…”

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Analysis of Paeoniae Radix by High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry

Zhao

Sun

2003

ANAL. SCI.

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A method has been developed for the qualitative analysis of paeonol, paeoniflorin and their derivatives in Paeoniae Radix by high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS). Gradient elution with acetonitrile-water solvent system was employed in an HPLC-ESI-MS study. The negative-ion ESI mode was suitable for these compounds. The peaks were identified by their mass spectra, UV spectra and fragments of their MS 2 spectra. The structures of three unknown compounds are inferred in this paper.

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“…11) Through studies of the chemical components of the Paeonia cortex, many glycosides were isolated and characterized from the polar fraction of mokdanpi ethanol-extract. [12][13][14] In addition, its multiple constituents have demonstrated a radical scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. 13,15) We focused on the activities of mokdanpi and investigated its potential use as an antiulcerogenic and anti-H. pylori drug.…”

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Anti-<i>Helicobacter pylori</i> and Antiulcerogenic Activities of the Root Cortex of <i>Paeonia suffruticosa</i>

Jung

Bae

Jeong

2013

Biological & Pharmaceutical Bulletin

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In this study, we evaluated the gastric protective activities of mokdanpi in vitro. Further, we used experimental ulcer models to identify the active ingredients of mokdanpi. As a preliminary evaluation of mokdanpi ethanolic extract and its ingredients, we assessed its radical scavenging activities. In addition, its antimicrobial activity against Helicobacter pylori (H. pylori) was investigated. The antiulcerogenic activity of the active ingredients was evaluated in pylorus-ligated rats, an HCl/ethanol-induced and an absolute ethanol-induced ulcer model. We confirmed the scavenging effect of the ethanolic extract of mokdanpi and its ingredients against 2,2-diphenyl-1-picrylhydrazyl, nitric oxide and superoxide radicals, and we demonstrated that mokdanpi could inhibit the colonization of H. pylori. In an HCl-ethanol-induced ulcer model, gallic acid and catechin (100 mg/kg) inhibited 40.6% and 41.7% of gastric lesions, respectively. Catechin (100 mg/kg) significantly reduced (p<0.05) the gastric secretion induced by pylorus ligature in rats in comparison to the control group. Gallic acid (100 mg/kg) significantly increased (p<0.05) the mucus contents in an ethanol-induced ulcer model. The antioxidant ingredients (catechin and gallic acid) present in mokdanpi play a major role in antiulcerogenic activity, and demonstrate novel activity against H. pylori. Key words Paeonia suffruticosa; Helicobactor pylori; gastric ulcer; gastric cancer; catechin; gallic acidA large portion of the world's population is afflicted with gastric diseases, such as gastric ulcer, gastritis, and gastric cancer. These diseases are induced by stress, smoking, infection by Helicobacter pylori (H. pylori), and nutritional deficiencies.1) Gastric ulcers result from an imbalance between aggressive factors (i.e., gastric acid, pepsin, stimulation of the vagus nerves, secretion of gastrin, and an increased number of parietal cells) and protective factors (i.e., bicarbonate ion, mucus productivity, mucus secretion, and prostaglandins). 2)In particular, frequent gastritis or gastric ulcer is chronic and leads to death. Another important risk factor is infection from H. pylori. Since reports indicate that H. pylori-induced gastritis leads to gastric cancer, the control of H. pylori in the stomach has become a target of treatment for gastric diseases. The antibodies for H. pylori are higher in patients with gastric cancer than in control groups.3) For eradication of H. pylori, a combination therapy with a proton pump inhibitor (PPI) or bismuth and antibiotics has been used. Nevertheless, the infection rate remains high and new therapeutic alternatives are needed because of antimicrobial resistance. In this regard, plant-derived extracts have been considered in the development of antiulcerogenic drugs.Mokdanpi, the root cortex of Paeonia suffruticosa ANDREWS (Panunculaceae), is an important crude drug with analgesic, sedative, and anti-inflammatory activities, and has been used as a remedy for cardiovascular extravasated blood and female genital diseas...

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New bioactive monoterpene glycosides from paeoniae radix.

Cited by 57 publications

References 0 publications

A New Monoterpene Glucoside from the Roots of Paeonia lactiflora

A New Monoterpene Glucoside from the Roots of Paeonia lactiflora

Analysis of Paeoniae Radix by High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry

Anti-<i>Helicobacter pylori</i> and Antiulcerogenic Activities of the Root Cortex of <i>Paeonia suffruticosa</i>

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