New biocide guanidine-containing nanocomposites

Горбунова, М. Н.; Lemkina, L. M.

doi:10.1007/s11051-014-2566-0

Cited by 8 publications

(8 citation statements)

References 36 publications

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“…Synthesis of silver nanocomposites was conducted by the reduction of AgNO 3 with NaBH 4 in aqueous solution of copolymer. Reaction proceeds via formation of the stable dark brown sols, from which water‐soluble nanocomposites were separated . Сharacteristics of nanocomposites are presented in Table .…”

Section: Resultsmentioning

confidence: 99%

“…As mentioned above, compounds containing guanidine groups are active toward a wide range of Gram‐positive and Gram‐negative bacteria. Our previous studies on antibacterial activity of AGC copolymers showed that they have a pronounced antimicrobial activity especially with respect to Gram positive microflora . MICs values of the poly(AGC‐VA) and poly(AGC‐VP) and their AgNCs measured for S.epidermidis 33 are summarized in Table .…”

Section: Resultsmentioning

confidence: 99%

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New guanidine‐containing nanocomposites impeding the growth of Staphylococcus epidermidis 33 and the biofilm formation

Горбунова

Lemkina

2015

J Biomedical Materials Res

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New water-soluble nanocomposites (AgNCs) based on Ag and copolymers of 2,2-diallyl-1,1,3,3-tetraethylguanidiniumchloride with N-vinylpyrrolidone [poly(AGC-VP)] and vinylacetate [poly(AGC-VA)] have been developed. Antibacterial action of new silver nanocomposites on S. epidermidis 33 (planctonic cells and biofilms) is reported in this study. AgNCs strongly inhibited biofilms formation of S. epidermidis 33. The viability of S. epidermidis 33 cells in biofilms was considerably reduced by new AgNCs. It has been shown that S. epidermidis 33 inactivation in biofilms occurs at AgNC concentrations > 5 times higher as compared to those inhibiting completely the planktonic cells. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 630-638, 2016.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

New guanidine‐containing nanocomposites impeding the growth of Staphylococcus epidermidis 33 and the biofilm formation

Горбунова

Lemkina

2015

J Biomedical Materials Res

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“…For example, antiseptics poviargolum, collargolum, and so on are used in traumatic surgery (purulent inflammatory wound infections), burn injury medicine (various infectious burns), otolaryngology (rhinitis, sinusitis, pharyngitis, otitis), ophthalmology (purulent conjunctivitis, keratitis), and so on. 9,10 The antimicrobial activity of polymer nanocomposites increases with decreasing size of AgNPs, so approaches to the preparation of small AgNPs (on average up to 10 nm) are attracting increasing attention of researchers.…”

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confidence: 99%

Nontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity

Pozdnyakov¹,

Emel’yanov²,

Кузнецова³

et al. 2016

IJN

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New nontoxic hydrophilic nanocomposites containing metallic silver nanoparticles (AgNPs) in a polymer matrix were synthesized by the chemical reduction of silver ions in an aqueous medium. A new nontoxic water soluble copolymer of 1-vinyl-1,2,4-triazole and N-vinylpyrrolidone synthesized by free radical-initiated polymerization was used as a stabilizing agent. Transmission electron microscopy, scanning electron microscopy, ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, atomic absorption, and thermogravimetric analysis were used to characterize polymeric AgNPs nanocomposites. The results showed that the diameter of the synthesized AgNPs ranged from 2 to 6 nm. The toxicity of the initial copolymer of 1-vinyl-1,2,4-triazole and N-vinylpyrrolidone and its nanocomposite with AgNPs was found to be more than 5,000 mg/kg. The synthesized AgNP polymeric nanocomposite showed significant antimicrobial activity against different strains of Gram-negative and -positive bacteria. The minimum inhibitory concentrations suppressing the growth of the microorganisms ranged from 0.5 to 8 µg/mL and the minimum bactericidal concentrations ranged from 0.5 to 16 µg/mL. The fabricated AgNP nanocomposites are promising materials for the design of novel nontoxic hydrophilic antiseptics and antimicrobial components for medical purposes.

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“…Highly stable hydrosols with isolated silver nanoparticles were prepared using the following matrix materials: water-soluble poly-N-vinylpyrrolidone [2][3][4] and its copolymer [5], 1-vinyl-1,2,4-triazole homo-and copolymers [6,7], and 2,2-diallyl-1,1,3,3-tetraethylguanidinium chloride copolymers [8].…”

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Copolymers of betulin esters and silver nanocomposites based on them

et al. 2016

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New biologically active silver nanocomposites based on the copolymer of lup-20(29)-ene-3,28-diol 28-O-vinylbenzoate with N-vinylpyrrolidone were prepared by the borohydride method. The formation of spherical nanoparticles with a mean diameter of 67 nm was confi rmed by scanning electron microscopy. The synthesized copolymers and silver nanocomposites exhibit cytotoxic activity and show promise for the development of new materials for medical purposes.Polyfunctional macromolecular compounds exhibit high performance as polymer matrices stabilizing metal nanoparticles and preventing their aggregation. The presence of functional groups of comonomers in copolymers favors their effi cient interaction with metal nanoparticles in early steps of their formation, controlling their growth, size, aggregation, and distribution in the polymer matrix and ensuring synergism of unique properties of the polymer matrix and metal nanoparticles.It is known from the literature that the particle stability is strongly infl uenced by the nature of the nanostabilizing matrix [1,2]. Highly stable hydrosols with isolated silver nanoparticles were prepared using the following matrix materials: water-soluble poly-N-vinylpyrrolidone [2-4] and its copolymer [5], 1-vinyl-1,2,4-triazole homo-and copolymers [6,7], and 2,2-diallyl-1,1,3,3-tetraethylguanidinium chloride copolymers [8].Natural monomers and polymers are also used as nanostabilizing substances [9][10][11], and nanocomposites prepared with them exhibit a broad spectrum of biological activity.This study was aimed at synthesis of copolymers of betulin С-28 esters [lup-20(29)-ene-3,28-diol 28-О-vinylacetate (BVA) and 28-О-vinylbenzoate (BVB)] with N-vinylpyrrolidone and acrylonitrile in the bulk in the presence of a radical initiator, azobis(isobutyronitrile) (AIBN), and at preparation of new water-soluble composites with silver nanoparticles stabilized with these triterpene-containing copolymers. EXPERIMENTALBetulin was prepared by the procedures described in [12].Vinylacetic (VAA) and vinylbenzoic (VBA) acids (Lancaster) were used without additional purifi cation.N-Vinylpyrrolidone (VP) (Lancaster) was dried over KОН and vacuum-distilled; the fraction with bp 65°С/1.5 mmHg, n D 20 1.5117, was used. Vinyl acetate (VA) (Lancaster) was purifi ed by distillation; the fraction with bp 72°С, n D 20 1.3951, was used.Acrylonitrile (AN) (Alfa Aesar) was purifi ed by distillation; the fraction with bp 78°С, n D 20 1.3910, was used.BVA and BVB were prepared as described in [13]. A mixture of 0.5 g (0.11 mmol) of betulin, 1.8 g (0.9 mmol) of dicyclohexylcarbodiimide (DCC), 0.28 g

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New biocide guanidine-containing nanocomposites

Cited by 8 publications

References 36 publications

New guanidine‐containing nanocomposites impeding the growth of Staphylococcus epidermidis 33 and the biofilm formation

New guanidine‐containing nanocomposites impeding the growth of Staphylococcus epidermidis 33 and the biofilm formation

Nontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity

Copolymers of betulin esters and silver nanocomposites based on them

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