Nontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity

Abstract

New nontoxic hydrophilic nanocomposites containing metallic silver nanoparticles (AgNPs) in a polymer matrix were synthesized by the chemical reduction of silver ions in an aqueous medium. A new nontoxic water soluble copolymer of 1-vinyl-1,2,4-triazole and N-vinylpyrrolidone synthesized by free radical-initiated polymerization was used as a stabilizing agent. Transmission electron microscopy, scanning electron microscopy, ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, atomic absorption, and thermogravimetric analysis were used to characterize polymeric AgNPs nanocomposites. The results showed that the diameter of the synthesized AgNPs ranged from 2 to 6 nm. The toxicity of the initial copolymer of 1-vinyl-1,2,4-triazole and N-vinylpyrrolidone and its nanocomposite with AgNPs was found to be more than 5,000 mg/kg. The synthesized AgNP polymeric nanocomposite showed significant antimicrobial activity against different strains of Gram-negative and -positive bacteria. The minimum inhibitory concentrations suppressing the growth of the microorganisms ranged from 0.5 to 8 µg/mL and the minimum bactericidal concentrations ranged from 0.5 to 16 µg/mL. The fabricated AgNP nanocomposites are promising materials for the design of novel nontoxic hydrophilic antiseptics and antimicrobial components for medical purposes.

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

“…So, these new silver (Ag) nanocomposites in a poly(VT-co-VP) matrix are promising carriers for hydrophilic antiseptics and antimicrobial drugs for medical applications to treat many infectious diseases, including surgically acquired ones. 13 A molybdenum disulfide (MoS 2 ) nanosheet was developed as a photothermal agent for tumor therapy. Surface modification of PEG has been accomplished during a facile approach to prepare soybean phospholipid-encapsulated MoS 2 (SP-MoS 2 ) nanosheets with excellent colloidal stability.…”

Green Synthesis of Potent Antimicrobial Silver Nanoparticles Using Different Plant Extracts and Their Mixtures

“…AgNPs were used to inhibit the growth of bacterial biofilms [5]. Further studies proved that AgNPs also possess antifungal activity [6]. However, AgNPs may undergo aggregation and form larger particles, which lowers their potential properties.…”

Synthesis and Characterization of Silver-Containing Nanocomposites Based on 1-Vinyl-1,2,4-triazole and Acrylonitrile Copolymer

“…The copolymer obtained (white powder) is well soluble in dipolar organic solvents (DMF, DMSO). Composition and structure of the copolymer were established by FTIR, 1 H, 13 С NMR technique, and elemental analysis data. Content of the triazole and acrylonitrile fragments in the copolymer was 51 and 49 mol%, respectively.…”

“…The ratio of the VT and AN links in the copolymer is 51 : 49 mol%. The composition of the copolymer was determined by quantitative 13 C NMR analysis (found: С, 59.28%; Н, 6.01%; N, 34.71%). The GPC traces for poly(VT-co-AN) were obtained using polystyrene standards.…”

“…Earlier we have reported on the synthesis and properties of nanocomposites with silver nanoparticles in a matrix of 1-vinyl-1,2,4-triazole homo-and copolymers, possessing plasmon absorption, water solubility, and antimicrobial activity [13][14][15][16].…”