New Biocompatible Mesoporous Silica/Polysaccharide Hybrid Materials as Possible Drug Delivery Systems

Abstract

A high number of studies support the use of mesoporous silica nanoparticles (MSN) as carriers for drug delivery systems due to its high biocompatibility both in vitro and in vivo, its large surface area, controlled pore size and, more than this, its good excretion capacity from the body. In this work we attempt to establish the optimal encapsulation parameters of benzalkonium chloride (BZC) into MSN and further study its drug release. The influence of different parameters towards the drug loading in MSN such as pH, contact time and temperature were considered. The adsorption mechanism of the drug has been determined by using the equilibrium data. The modification process was proved using several methods such as Fourier transform-infrared (FT-IR), ultraviolet-visible (UV-VIS), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). Since MSN shows a lower drug release amount due to the agglomeration tendency, in order to increase MSN dispersion and drug release amount from MSN, two common biocompatible and biodegradable polymers were used as polymer matrix in which the MSN-BZC can be dispersed. The drug release profile of the MSN-BZC and of the synthesized hybrid materials were studied both in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Polymer-MSN-BZC hybrid materials exhibit a higher drug release percent than the pure MSN-BZC when a higher dispersion is achieved. The dispersion of MSN into the hybrid materials was pointed out in scanning electron microscope (SEM) images. The release mechanism was determined using four mathematic models including first-order, Higuchi, Korsmeyer–Peppas and Weibull.

Potent‐By‐Design: Amino Acids Mimicking Porous Nanotherapeutics with Intrinsic Anticancer Targeting Properties

“…This observation is consistent with numerous other studies showing that MSN is a nontoxic and a cyto‐compatible material. [ 24,25 ] In stark contrast, a significant dose‐dependent decrease in the cancer cell viability by approximately two to sixfold was observed in the Nano‐PAAMs treated groups compared to the NH 2 –MSN group (Figure 2D). Interestingly, the anticancer effects of the Nano‐PAAM variants were observed to scale according to the hydrophobicity of the conjugated EAA side chain.…”

Naturally-Derived Biphasic Calcium Phosphates through Increased Phosphorus-Based Reagent Amounts for Biomedical Applications

“…The morphological aspects such as texture, roughness and topographic patterns stand as well as essential factors for the biological success of ceramic materials/ceramic materials-based structures [28,29,30]. Along with chemical composition, surface features dictate the cellular behavior in terms of adhesion, differentiation, migration and proliferation (both in vitro and in vivo), and the degree of bone formation [19,31,32,33,34,35,36].…”

Poly(oligo(ethylene glycol) methyl ether methacrylate) Capped pH-Responsive Poly(2-(diethylamino)ethyl methacrylate) Brushes Grafted on Mesoporous Silica Nanoparticles as Nanocarrier

“…Next, a mixture containing 0.25 mL 2-bromo-2-methylpropionyl bromide (2.02 mmol) and 5 mL DCM was dropwise added to the suspension. The reaction was allowed to react under ambient temperature for 48 h. Finally, the modified silica nanoparticles (MSN–Br) were centrifuged and thoroughly washed with ethanol and DCM [ 19 ].…”

“…MSNs offer several unique properties and advantageous structures, such as high surface area and pore volume, uniform pore size, stable mesostructure [ 16 ], modifiable morphology [ 17 ], and excellent biocompatibility [ 18 ]. Despite the potential advantages of MSNs for drug delivery applications, pure MSNs tend to aggregate when directly exposed to biological environments, leading to uncontrolled drug release patterns [ 19 , 20 ]. These drawbacks could be minimized by using biocompatible polymers to coat the surface of silica nanoparticles in order to form different structures such as yolk–shell [ 21 ], core–shell [ 22 ], and brushes [ 23 ].…”