New bis-aminomercaptotriazoles and bis-triazolothiadiazoles as possible anticancer agents

Synthesis and Antimicrobial Activity of Bis-[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazin-3-yl)phenyl]methanes and Bis-[(triazolo[3,4-b]thiadiazipin-3-yl)phenyl]methanes

“…[16][17][18][19][20][21] In addition, it was reported that triazole fused with a six-membered ring system is also found to possess diverse applications in the field of medicine. [22][23][24][25] The commonly known systems are triazolo-pyridines, 26 triazolo-pyridazines, 27 triazolo-pyrimidines, 28 triazolo-triazines, 29 triazolo-pyrazines, 30 triazolo-triazenes, 31 a few monomeric triazolo-thiadiazine, 31 and triazolo-thiadiazepines, 32 although there are not many triazoles fused to thiadiazines and thiadiazepines, there is a number of them that are incorporated into a wide variety of therapeutically important compounds possessing a broad spectrum of biological activities. [33][34][35][36][37] In recent years attention has been increasingly paid to the synthesis of bis-heterocyclic compounds which exhibit various biological activities, [38][39][40][41] including antibacterial, fungicidal, tuberculostatic and plant-growth regulating properties.…”

Synthesis of 6-(5-Methylisoxazol-3yl)-3-alkyl Sulfanyl-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazoles

“…In recent years, fused 1,2,4-triazolo [3,4-b] 1,3,4-thiadiazoles have significant attraction due to their promising pharmacological activities such as anti-microbial [9,10], anti-inflammatory [11,12], antitumor [13][14][15], anti oxidant [16], analgesic [17], antiviral [18,19], antifungal [20], antibacterial [21], anti-helminthes [22], CNS stimulants [23], and plant growth regulatory effects [24]. Prompted by the aforementioned biological significance of isoxazoles and triazolo-thiadiazole derivatives, it is desired to synthesize the isoxazole substituted triazolothiadiazole derivatives (Scheme 1).…”

Synthesis, Characterization, Anti-Microbial and Anti-Cancer Activity of Novel Heterocyclic System Containing Bridgehead Nitrogen Atom

“…The heterocyclic systems encompassing 1,3,4-thiadiazole and thiadiazine are explored to the maximum extent owing to their wide spectrum of pharmacological activities, such as fungicidal, insecticidal, bactericidal, herbicidal 6 , anti-tumor 7 , anti-inflammatory 8 , anti-viral 9 and CNS stimulant properties 10 .…”