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Oxadiazole derivatives R 0290Synthesis and Anticancer Activity Studies on Some 2-Chloro-1,4-bis-(5-substituted-1,3,4-oxadiazol-2-ylmethyleneoxy)phenylene Derivatives. -A variety of the title oxadiazole derivatives [cf. (III), (V)] are synthesized by cyclization reactions of bis(aroyl hydrazine) (I) derived from 2-chloro-1,4-phenylenedioxy-bis(acetic acid). Compounds (IIId) and (IIIf) show significant anticancer activity against a variety of cancer cell lines. -(HOLLA*, B. S.; POOJARY, K. N.; BHAT, K. S.; ASHOK, M.; POOJARY, B.; Indian J.

1997 ring closure reactions ring closure reactions O 0130 -054Synthesis, Characterization, and Antifungal Activity of Some N-Bridged Heterocycles Derived from 3-(3-Bromo-4-methoxyphenyl)-4amino-5-mercapto-1,2,4-triazole.-Screening of the novel compounds reveal that all derivatives exhibit significant antifungal activity. Imine (VII) and the title compound (I) possess the highest activity. -(HOLLA, B. S.; POOJARY, K. N.; KALLURAYA, B.; GOWDA, P. V.; Farmaco 51 (1996) 12, 793-799; Dep. Post-Grad. Stud. Res. Chem., Mangalore Univ., Mangalagangothri 574 199, India; EN)

Their Derivatives. -A series of new 2,4-substituted quinolines (V) is synthesized by condensation of the hitherto unreported quinoline-4-carboxylic acids (III) with various substituted triazoles (IV). Products (V) show good antibacterial activity. -(HOLLA*, B. S.; POOJARY, K. N.; POOJARY, B.; BHAT, K. S.; KUMARI, N. S.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 44 (2005) 10, 2114-2119; Dep. Postgrad. Stud. Res. Chem., Mangalore Univ., Mangalagangothri, Mangalore 574 199, India; Eng.) -H. Haber 05-138