New cancers arising in 1,563 patients with carcinoma of the cervix treated by irradiation

Morton, Richard F.; Villasanta, U

doi:10.1016/0002-9378(73)90391-8

Cited by 18 publications

(3 citation statements)

References 7 publications

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“…Bachulis and Williams 14 reported 1441 patients with cancer of the cervix, 32 of whom (2.2 per cent) had a second PMT; however, among the 108 cases of MPMT in female patients in that study, the initial lesion in 20 (18.5 per cent) had been the cervical one. In those and other series, the new PMTs were located in vaginal or vulvar areas, the anorectal area, the breast, or the skin, 3,20,39–43 and most appeared within one year after the diagnosis of cervical cancer had been made 20 …”

Section: Discussionmentioning

confidence: 77%

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Multiple Primary Malignant Tumors (MPMT): Study of 68 Autopsy Cases (1963–1980)

Lee

Myers

Scharyj

et al. 1982

J American Geriatrics Society

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Review of 8428 autopsies (1870 for known cancer) showed that 68 patients had had multiple primary malignant tumors (MPMT). Those 68 cases represented 0.8 per cent of all autopsies done, 3.6 per cent of all cancer autopsies. Diagnosis of MPMT was made only at autopsy in 24 cases (35.3 per cent). Thirty-six patients were male, 32 female. Their average age was 64 +/- 2.3 years. Cancers were "synchronous" (diagnosed within a six-month period) in 15 patients, "metachronous" (diagnosed at greater than six-month intervals) in 49, and "combined" in four. Metastatic foci were seen in 53 patients. Fifty-nine patients had two primary malignant tumors (PMTs); seven had three PMTs; one had four PMTs; and one had five PMTs, for a total of 148 tumors. Over half (53.1 per cent) of the second PMTs occurred within five years of the first PMTs. First PMTs were most common in the hematopoietic system and the cervix; second PMTs were most common in the lungs and the hematopoietic system. Second PMTs were less well differentiated than index PMTs. Forty-four deaths had not been directly tumor-related. Nineteen patients with metachronous MPMT lived more than ten years. Of 23 patients with one pulmonary PMT, 22 died within two years. Concomitant findings of pulmonary artery embolism, gallstone(s), thyroid or prostatic hyperplasia, and benign tumor were common in these patients. It is hoped that accumulation of data from this and other series of MPMT will provide insight into the clinicopathologic characteristics, the causes, and the interrelationships of these lesions that constitute primarily a disease of the elderly.

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Section: Discussionmentioning

confidence: 77%

“…It has been suggested that cervical cancer may be followed by an increased incidence of lung cancer 5,40 . In the 11 autopsies of patients with MPMT, one of which was of the cervix, four showed cancer in the lung.…”

Section: Discussionmentioning

confidence: 99%

Multiple Primary Malignant Tumors (MPMT): Study of 68 Autopsy Cases (1963–1980)

Lee

Myers

Scharyj

et al. 1982

J American Geriatrics Society

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“…Some advocate a surgical procedure as the most effective (17), while others favor radiotherapy as the initial choice. The results in these series seem to be equally good and comparable both in regards to cure rate and complication rate (3,12,14,15,19,21). Several attempts have been made to correlate histologic cell type with the prognosis of the patient with a uterine cervical carcinoma.…”

Section: Discussionmentioning

confidence: 66%

Prognosis, Recurrences and Metastases Correlated to Histologic Cell Type in Carcinoma of the Uterine Cervix

Johansson

Johnsson

Lindberg

et al. 1976

Acta Obstet Gynecol Scand

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An analysis of 230 patients treated with radiotherapy for cervical cancer stages I and II is presented. No positive correlation to cell type was found as regards the number of failures, recurrence rate or the frequency of regional or distant metastases. Although different biological behavior might be shown by cancers of varying cell types, adequate planning and staging before treatment seems to be of better prognostic value.

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Gynecologic cancer treatment: Risk factors for therapeutically induced neoplasia

Messerschmidt¹,

Hoover²,

Young³

1981

Cancer

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Therapeutic intervention in a course of illness, while producing the desired result, also may have some adverse long-term effects on the patient. Second malignancies are one of the known complications of therapy. The treatments of gynecologic cancers by surgery, irradiation and chemotherapy have been associated with subsequent neoplasms. Care must be exercised in associating previous therapy and a subsequent malignancy. "Naturally" occurring second cancers must be separated from those which are iatrogenic. Associations in the literature have been made involving malignancies as a sequelae of prior gynecologic therapy. The use of normal skin from the thigh to fabricate an artificial vagina has resulted in more squamous cell carcinomas than expected. Alkylating agents used in the treatment of ovarian cancer and other diseases have been shown to lead to an increased risk of leukemia. Irradiation therapy, however, has not yet been shown to be related to leukemia in cervical cancer patients. The incidence of lymphoma and uterine, urinary bladder and colon carcinomas has been associated with prior irradiation for gynecologic disease. The literature regarding the therapeutically induced risk factors in gynecologic therapy is reviewed and areas of our knowledge that require more investigation are identified.

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New cancers arising in 1,563 patients with carcinoma of the cervix treated by irradiation

Cited by 18 publications

References 7 publications

Multiple Primary Malignant Tumors (MPMT): Study of 68 Autopsy Cases (1963–1980)

Multiple Primary Malignant Tumors (MPMT): Study of 68 Autopsy Cases (1963–1980)

Prognosis, Recurrences and Metastases Correlated to Histologic Cell Type in Carcinoma of the Uterine Cervix

Gynecologic cancer treatment: Risk factors for therapeutically induced neoplasia

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