This study examined the consequences of changes in minimum temperature, maximum temperature, relative humidity, and rainfall on the yields of maize, cassava, and yam per hectare of land in the Ashanti Region of Ghana. Correlation analysis of each climatic condition on the yield of each crop per hectare of land revealed that each of the climatic conditions was significant in predicting the crop yields. Separate multiple linear regression models were obtained for crop yield per hectare of land under all the climatic conditions. The regression models showed that an increase in maximum temperature reduces the yield of all the crops, whereas an increase in minimum temperature reduces only the yield of maize. Increases in relative humidity reduce the yield of maize alone, while increases in rainfall reduce the yield of only cassava. The significant multiple linear regression model for each crop yield indicated that 63.8% of the variations in the yield of maize per hectare of land, 74.3% of the variations in the yield of cassava per hectare of land, and 64.2% of the variations in the yield of yam per hectare of land are accounted for by minimum temperature, maximum temperature, relative humidity, and rainfall. We encourage the Government of Ghana, the Ministry of Food and Agriculture, and all stakeholders in the agriculture sector to increase their campaign on the consequences of climate change on the yield of these crops. They should educate farmers on the effects of overreliance on rainfed and traditional agricultural methods, introduce them to modern methods of agriculture, and provide them with varieties of these crops with higher-yielding capacities in higher temperatures.