New cerium(III) and neodymium(III) complexes as cytotoxic agents

Abstract

The cerium(III) and neodymium(III) complexes of 5-aminoorotic acid were synthesized and characterized by means of spectral data (IR, Raman, 1 H NMR and 13 C NMR) and elemental analysis. Significant differences in the IR spectra of the complexes were observed as compared with the spectrum of the ligand. A comparative analysis of the Raman spectra of the complexes with that of the free 5-aminoorotic acid allowed a straightforward assignment of the vibrations of the ligand groups involved in coordination. 1 H NMR and 13 C NMR spectra confirmed the formation of the complexes. The ligand and the complexes were tested for the cytotoxic activities on the chronic myeloid leukemia-derived K-562, overexpressing the BCR-ABL fusion protein, and the non-Hodgkin lymphoma-derived DOHH-2, characterized by a rexpression of the antiapoptotic protein bcl-2 cell lines. The results obtained indicate that the tested compounds exerted a considerable cytotoxic activity upon the evaluated cell lines in a concentration-dependent manner, which enabled the construction of dose-response curves and the calculation of the corresponding IC 50 values. Cytotoxicity towards tumor cells was determined for a broad concentration range. The inorganic salts exerted a very weak cytotoxic effect on these cells that is in contrast to the lanthanide complexes, which exhibited potent cytotoxic activity towards K-562 and DOHH-2 cell lines.

Fluorescent Gadolinium(III)‐Oligopeptide Complexes and Carbon Nanotube Composite as Dual Modality Anticancer Agents

“…Simple gadolinium(III) nitrate hexahydrate displayed IC 50 value at 50 μM under similar experimental conditions. Potent cytotoxic activity towards non‐Hodgkin lymphoma‐derived DOHH‐2 cell lines by cerium(III) and neodymium(III) complexes of 5‐aminoorotic acid and samarium(III), europium(III), terbium(IIII) and dysprosium(III) complexes of 5, 7‐dibromo‐8‐quinolinol against BEL7404, SGC7901, A549 cell lines have been investigated ,. The IC 50 values of these complexes are reportedly in sub‐micromolar ranges.…”

Synthesis and Characterization of Neodymium(III) and Gadolinium(III)‐Substituted Hydroxyapatite as Biomaterials

“…Meanwhile, it has been re-ported that Nd inorganic salts showed a very weak cytotoxic effect on cells. 25 Here, all Nd 31 -doped HA powders were characterized as noncytotoxic, including Nd20, which had two phases, metal ion-substituted HA and Nd(OH) 3 (Table IV, Fig. 11).…”

Lanthanide(III) complexes are more active inhibitors of the Fenton reaction than pure ligands

“…The synthesis of the lanthanide(III) complexes of AOA and CCA as well as their theoretical, analytical, spectral, and structural characterization have been previously reported by us. [22][23][24][25][26]28,29 Shortly: the compounds used for preparing the solutions were Merck products, p.a. grade:…”

“…21 In a series of papers, we investigated the molecular structure, energetic, and spectroscopic properties of different coumarin derivatives and their lanthanide complexes, as well as their pharmacological activity. [15][16][17][22][23][24][25][26] These studies highlighted the potential for developing novel lanthanide complexes mainly as anti-cancer therapeutics. However, more analogs are required to obtain better activity profiles for this class of compounds.…”