New chiral and restricted-access materials containing glycopeptides as selectors for the high-performance liquid chromatographic determination of chiral drugs in biological matrices

A review of current trends and advances in modern bio-analytical methods: Chromatography and sample preparation

“…RAMs can be classified according to the protein exclusion mechanism into the following two groups-RAM with a physical barrier (reverse phase, alkyldiol-silica material, porous silica with combined ligand) or RAM with a chemical barrier (semi-permeable surface, protein-coated silica, mixed-functional materials or shielded hydrophobic phase) [247]. Also during the development of RAM supports, enantioselective RAMs using glycopeptides antibiotics as chiral selector [250] or weak cation-exchange RAM were introduced [251].…”

Chiral Separations: Fundamental Review 2010

“…Two new chiral and restricted-access materials containing glycopeptide antibiotics as chiral selectors used either teicoplanin or teicoplanin aglycon for the HPLC determination of chiral drugs in biological matrixes (111). A novel chiral selector, eremomycin, was first evaluated as a chiral selector in CE, then immobilized on silica, and evaluated for use as a CSP in HPLC (112).…”

Biocompatible chiral monolithic stationary phase synthesized via atom transfer radical polymerization for high performance liquid chromatographic analysis

“…These chiral RAMs were mainly prepared based on porous silica gel support, which were surface-modified with hydrophilic polymer networks (such as polyvinyl alcohol and albumin from bovine serum) and inner-bonded with chiral selectors (such as ␤-CD and glycopeptide antibiotics) [16][17][18][19]. As stationary phases for HPLC, the chiral RAMs allow the analytes penetrating into the pores of silica gel and interact with the chiral selectors bonded on the inner surface, while proteins are eluted in the void volume.…”