A review of current trends and advances in modern bio-analytical methods: Chromatography and sample preparation

Nováková, Lucie; Vlčková, Hana

doi:10.1016/j.aca.2009.10.004

Cited by 504 publications

(250 citation statements)

References 276 publications

(316 reference statements)

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“…The elution of target analytes could require different solvents, when SPE is applied in order to perform the class compound fractionation. To achieve optimal SPE extraction conditions, the choice of sorbent is a key factor because this can control parameters of primary importance such as selectivity, affinity and capacity [18]. This choice depends strongly on the nature of the analytes and their physical and chemical properties, which should define the interaction with the chosen sorbent.…”

Section: Solid-phase Extraction (Spe)mentioning

confidence: 99%

Current Trends in Sample Treatment Techniques for Environmental and Food Analysis

Lucci¹,

Pacetti²,

Núñez³

et al. 2012

Chromatography - The Most Versatile Method of Chemical Analysis

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Section: Solid-phase Extraction (Spe)mentioning

confidence: 99%

Current Trends in Sample Treatment Techniques for Environmental and Food Analysis

Lucci¹,

Pacetti²,

Núñez³

et al. 2012

Chromatography - The Most Versatile Method of Chemical Analysis

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“…Today, there is a large choice of column packed with fully porous sub-2 m particles which are compatible with pressures up to 1,200 bar [3,10,11,188]. These stationary phases consist of (i) hybrid silica material prepared from two monomers, i.e., tetraethoxysilane and bis(triethoxysilyl) ethane which incorporates ethylene bridges (the high degree of cross-linking ensures strong mechanical and hydrolytic stability) [189], or (ii) classical silica simply packed under much higher pressure conditions.…”

Section: Upper Pressure Limit Of Current Instrumentmentioning

confidence: 99%

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Fekete¹,

Perrenoud²,

Guillarme

2014

CCHG

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Abstract:The current trend in high performance liquid chromatography (HPLC) tends toward the achievement of higher separation efficiency and shorter analysis time. Indeed, better performance in LC has become increasingly important in recent years mainly driven by the challenges of either analyzing more complex samples or increasing the numbers of samples per time unit. In the recent development of particle technology, the use of fully porous sub-2 m particles and sub-3 m shell particles have received considerable attention. Beside packed columns, the new generation of silica-based monolithic columns also offers very high separation power. However, to take full advantage of these innovative phases, the chromatographic system has also to be drastically optimized in terms of upper pressure limit and system volume.This revolution in column technology now spreads and covers several modes of liquid chromatography such as reversedphase liquid chromatography (RPLC), hydrophilic interaction liquid chromatography (HILIC), or even supercritical fluid chromatography (SFC). The HILIC and SFC, which can be considered as alternative modes of chromatography, could also be useful to extend the applicability of chromatography towards the analysis of very hydrophilic and lipophilic compounds, respectively.The present review gives an insight about the theory behind the success of current column technology and presents a summary of latest applications, using various modes of one-dimensional chromatography (RPLC, HILIC, SFC). This paper also shows that theoretically expected column efficiency could sometimes be compromised in practical work especially in the case of narrow bore columns.

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“…Nowadays, there are several new approaches in HPLC that enable the reduction of the analysis time without compromising resolution and separation efficiency. Among them, high temperature liquid chromatography (HTLC), ultra-high performance liquid chromatography (UHPLC), fused core columns, hydrophilic interaction liquid chromatography (HILIC) and the use of monolithic columns have been reviewed in the bio-analytical area [2]. It is a little known fact that the very first monolithic columns were initially used in gas chromatography (GC) more than 30 years ago.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances and Uses of Monolithic Columns for the Analysis of Residues and Contaminants in Food

et al. 2015

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Abstract:Monolithic columns are gaining interest as excellent substitutes to conventional particle-packed columns. These columns show higher permeability and lower flow resistance than conventional liquid chromatography columns, providing high-throughput performance, resolution and separation in short run times. Monoliths possess also great potential for the clean-up and preparation of complex mixtures. In situ polymerization inside appropriate supports allows the development of several microextraction formats, such as in-tube solid-phase and pipette tip-based extractions. These techniques using porous monoliths offer several advantages, including miniaturization and on-line coupling with analytical instruments. Additionally, monoliths are ideal support media for imprinting template-specific sites, resulting in the so-called molecularly-imprinted monoliths, with ultra-high selectivity. In this review, time-saving LC columns and preparative applications applied to the analysis of residues and contaminants in food in 2010-2014 are described, focusing on recent improvements in design and with emphasis in automated on-line systems and innovative materials and formats.

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A review of current trends and advances in modern bio-analytical methods: Chromatography and sample preparation

Cited by 504 publications

References 276 publications

Current Trends in Sample Treatment Techniques for Environmental and Food Analysis

Current Trends in Sample Treatment Techniques for Environmental and Food Analysis

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Recent Advances and Uses of Monolithic Columns for the Analysis of Residues and Contaminants in Food

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