New Chronic Pain Treatments in the Outpatient Setting: Review Article

Grandhe, Radhika; Souzdalnitski, Dmitri; Gritsenko, Karina

doi:10.1007/s11916-016-0563-y

Cited by 5 publications

(3 citation statements)

References 46 publications

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“…Chronic pain management is a challenge entrusted to a limited number of effective therapeutic options [146] and novel pharmacological targets [114,147,148]. α 2 AR emerges as a key player in the pathological nervous network underlying neuropathic pain.…”

Section: Discussionmentioning

confidence: 99%

α₂ Adrenoceptor: a Target for Neuropathic Pain Treatment

Mannelli

Micheli²,

Crocetti³

et al. 2016

MRMC

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Neuropathic pain is originated from different alterations of the nervous system. The difficulty of treatment strongly impairs quality of life of affected people. It is associated with severe, chronic sensory disturbances characterized by spontaneous pain, increased responsiveness to painful stimuli and pain perceived in response to normally non-noxious stimuli. The underlying mechanisms are complex and involve both peripheral and central nervous components. The noradrenergic system plays a pivotal role in the control of pain since its widespread distribution in the "pain matrix" representing a valuable therapeutic target. This review focused on the α2 adrenoceptor subtype modulation as strategy for neuropathic pain relief. Drugs acting as direct α2 adrenoceptor agonists (clonidine and dexmedetomidine) were analyzed as well as the indirect α2 adrenoceptor modulators. The overview included norepinephrine reuptake inhibitors (reboxetine, maprotiline), serotonin/norepinephrine reuptake inhibitors (venlafaxine, milnacipran, amitriptyline, duloxetine, bicifadine) and the compounds characterized by a double pharmacodynamic mechanism combining the norepinephrine reuptake inhibition and the μ opioid agonist profile (tramadol and tapentadol). A summary of recent compounds was illustrated.

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Section: Discussionmentioning

confidence: 99%

α₂ Adrenoceptor: a Target for Neuropathic Pain Treatment

Mannelli

Micheli²,

Crocetti³

et al. 2016

MRMC

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“…From a biopsychosocial perspective, chronic pain presents in the context of a complex and multifaceted interplay of a patient’s physiological, emotional, cognitive, behavioral and sociocultural factors 2. In consequence, multimodal and interdisciplinary treatments are considered the method of choice in the treatment and management of chronic pain 3,4. Psychological interventions have been shown to increase self-management and coping-strategies, and to reduce disability as well as emotional distress in chronic pain patients 2…”

Section: Introductionmentioning

confidence: 99%

<p>Internal health locus of control as a predictor of pain reduction in multidisciplinary inpatient treatment for chronic pain: a retrospective study</p>

Zuercher-Huerlimann¹,

Stewart²,

Egloff³

et al. 2019

JPR

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Purpose Chronic pain is a major health concern and its treatment requires physiological as well as psychological interventions. This study investigates the predictive value of health locus of control (HLOC) in pain intensity in chronic pain patients in an inpatient treatment setting. Patients and methods Data of 225 patients with a chronic pain condition were collected in a psychosomatic university clinic in Switzerland. Self-report assessment tools were used to measure pain intensity pre- and posttreatment and with a questionnaire dimensions of the HLOC were captured. Using hierarchic linear regression analysis, the predictive value of HLOC was investigated. Results A higher internal HLOC at pre-treatment was associated with a greater reduction in pain intensity from pre- to posttreatment ( β = −0.151, p <0.05). For social-external and fatalistic-external HLOC no significant effects were observed. Conclusion Internal HLOC showed predictive value regarding the reduction in pain intensity in a multidisciplinary inpatient treatment for chronic pain, whereas social-external and fatalistic-external HLOC did not. Early interventions to strengthen internal beliefs of health control may be a promising component in multidisciplinary inpatient treatment for patients with chronic pain.

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“…Over the last decades, physicians' communication in health care has changed from a biomedical to a more patient-centred (Balint, 1969;Thompson, 2007) and recently a person-centred approach (Santana et al, 2018;Starfield, 2011), rooted in the biopsychosocial model (Engel, 1977). This change has an important impact on the treatment, for example, of chronic pain diseases, which are nowadays sought to be treated from a multidimensional perspective (Gatchel, Peng, Peters, Fuchs, & Turk, 2007;Grandhe, Souzdalnitski, & Gritsenko, 2016). A large review of costs and consequences of chronic non-malignant pain found pain to have a significant negative impact on quality of life, ability to work and activities of daily living (Moore, Derry, Taylor, Straube, & Phillips, 2014).…”

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confidence: 99%

Doctor–patient communication about existential, spiritual and religious needs in chronic pain: A systematic review

Andersen

Hvidt²,

Hvidt

et al. 2019

Archive for the Psychology of Religion

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Research documents that many chronic non-malignant pain patients experience existential, spiritual and religious needs; however, research knowledge is missing on if and how physicians approach these needs. We conducted a systematic review to explore the extent to which physicians address these needs in their communication with chronic non-malignant pain patients and to explore the facilitators and challenges of this communication. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching Embase, Medline, Scopus and PsycINFO. The quality of the included articles was assessed based on design-specific screening tools. We included four of 2337 screened articles and found the quality to be good. Physicians’ communication about existential, spiritual and religious needs was given low priority and depended on the patients’ own initiative, except when clinicians were interested in holistic care. Patient dissatisfaction with the physician’s attention to these needs was related to higher pain and depression. Physicians’ challenges for addressing these needs were their tendency to prioritize physiological aspects and close further elaboration of existential needs when addressed by the patients. The main facilitator was the individual physician’s willingness to listen with openness and empathy to the patients’ existential concerns. A tentative conclusion is that physicians rarely meet the existential, spiritual and religious needs of their chronic non-malignant pain patients. This might be due to higher priority of physical aspects, lack of time and a lack of knowledge about the importance of and training in the ability to address these needs. Further research is needed on physicians’ communication about existential, spiritual and religious needs and on their training in here.

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New Chronic Pain Treatments in the Outpatient Setting: Review Article

Cited by 5 publications

References 46 publications

α₂ Adrenoceptor: a Target for Neuropathic Pain Treatment

α₂ Adrenoceptor: a Target for Neuropathic Pain Treatment

<p>Internal health locus of control as a predictor of pain reduction in multidisciplinary inpatient treatment for chronic pain: a retrospective study</p>

Doctor–patient communication about existential, spiritual and religious needs in chronic pain: A systematic review

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New Chronic Pain Treatments in the Outpatient Setting: Review Article

Cited by 5 publications

References 46 publications

α2 Adrenoceptor: a Target for Neuropathic Pain Treatment

α2 Adrenoceptor: a Target for Neuropathic Pain Treatment

<p>Internal health locus of control as a predictor of pain reduction in multidisciplinary inpatient treatment for chronic pain: a retrospective study</p>

Doctor–patient communication about existential, spiritual and religious needs in chronic pain: A systematic review

Contact Info

Product

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α₂ Adrenoceptor: a Target for Neuropathic Pain Treatment

α₂ Adrenoceptor: a Target for Neuropathic Pain Treatment