New Computerized Tomogram (CT) Indices for Pectus Excavatum: Tools for Assessing Modified Techniques for Asymmetry in Nuss Repair

Lee, Cheol Sae; Park, Hyung J.; Lee, Seock Yeol

doi:10.1378/chest.126.6.1840

Cited by 36 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pathological changes in these small structures can be imaged only indirectly due to limited spatial resolution of the current imaging techniques [5, 25]. Air trapping reflects changes in small airways (below HRCT spatial resolution) [24, 26]. …”

Section: Discussionmentioning

confidence: 99%

“…Lee et al [24] observed increased air trapping in patients with moderate and severe asthma and even in mild asthma as compared to normal control subjects. In the study of Arakawa and Webb [27] air trapping on expiratory HRCT scans in patients with no abnormalities on inspiratory scans was most often associated with obliterative bronchiolitis and asthma.…”

Section: Discussionmentioning

confidence: 99%

“…At the same time, nondependent segments (middle lobe, lingula, anterior segments of the upper lobes) exhibit a lower density increase, also referred to as segmental air trapping, which was a physiological finding [12]. The extension of air trapping in healthy subjects is limited [24] and the size of the area of focal air trapping could distinguish asthma patients from healthy subjects, which was confirmed by Newman et al [28]. The E/I ratio (diffuse air trapping) was also higher in 24 asthmatic patients in the study of Carr et al [6].…”

Section: Discussionmentioning

confidence: 99%

“…Focal air trapping did not correlate with bronchial wall thickness in our study. It is probably a more complex process, dependent not only on remodeling but also on other factors such as local gradients, elastic recoils and mechanical stresses [23, 24]. …”

Section: Discussionmentioning

confidence: 99%

“…The E/I ratio is an easily obtained, quantitative method which could be used to detect small airway obstruction (air trapping) and emphysema [24]. Inspiratory and expiratory scans were matched using anatomic landmarks.…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

High-Resolution Computed Tomography Evaluation of Peripheral Airways in Asthma Patients: Comparison of Focal and Diffuse Air Trapping

Mikoś

Grzanka²,

Sładek³

et al. 2008

Respiration

View full text Add to dashboard Cite

Background: Air trapping evaluated in high-resolution computed tomography (HRCT) reflects changes in small bronchi. We simultaneously evaluated focal and diffuse air trapping in asthmatic patients. Objectives: (1) To evaluate air trapping and bronchial wall thickness in asthmatics. (2) To estimate the relationship between air trapping and bronchial wall thickness, pulmonary function tests (PFTs), age, gender and asthma severity. (3) To compare air trapping between subgroups of asthmatic patients with normal FEV₁ % pred. and FEV₁/FVC % and controls. (4) To compare air trapping and bronchial wall thickness between aspirin-induced asthmatics (AIA) and aspirin-tolerant asthmatics (ATA). Methods: Both groups (asthmatics and controls) included 30 patients. All patients underwent HRCT and PFTs. Results: Focal (p < 0.0001) and diffuse (p = 0.0004) air trappings and bronchial wall thickness (T: p < 0.0001; T/D: p < 0.0001; WA%: p < 0.0001) were significantly greater in asthmatics. Focal and diffuse air trappings were inversely correlated (p = 0.021). Diffuse air trapping correlated with bronchial wall thickness: T/D (p = 0.047), T (p = 0.037), and WA% (p = 0.048). There was a significant difference in the extent of focal air trapping between a subgroup of asthmatics with normal FEV₁ % pred. and FEV₁/FVC % and controls (p < 0.0001). There were no significant differences in focal (p = 0.095) and diffuse air trapping (p = 0.186) and bronchial wall thickness (T: p = 0.086; T/D: p = 0.428; WA%: p = 0.428) between AIA and ATA patients. Conclusions: Both focal and diffuse air trappings provide valuable diagnostic information and therefore deserve to be estimated. The lack of significant differences in air trapping and bronchial wall thickness between AIA and ATA patients needs further investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

High-Resolution Computed Tomography Evaluation of Peripheral Airways in Asthma Patients: Comparison of Focal and Diffuse Air Trapping

Mikoś

Grzanka²,

Sładek³

et al. 2008

Respiration

View full text Add to dashboard Cite

show abstract

Demonstration of the heterogeneous distribution of asthma in the lungs using CT and hyperpolarized helium‐3 MRI

Aysola

Lange

Castro

et al. 2010

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Asthma is a chronic inflammatory disease that affects both the large and small airways and results in bronchoconstriction, mucous hypersecretion, smooth muscle hypertrophy, and subepithelial fibrosis. To gain insight into the pathophysiology of asthma, chest computed tomography (CT) has been investigated as a noninvasive method to evaluate airway wall thickness of medium and large airways. Hyperpolarized gas MRI can assess the functional alterations of airflow within the lung resulting from the structural changes in the airways. In this article, we review the application of CT-based techniques and hyperpolarized gas MRI to study structural and functional changes in asthma. From the result of studies with CT and hyperpolarized gas MRI, it is becoming apparent that asthma has a regional distribution within the lung, that is, some areas of the lung are more affected than others. Furthermore, there appears to be some persistence to this distribution which may explain the observed patterns of airway remodeling and provide targets for localized therapies such as local application of anti-inflammatory agents or bronchial thermoplasty. Thus, cross sectional imaging in asthma is providing new insights into the pathophysiology of the disease and has the potential to become essential in the guidance of localized treatments.

show abstract

Status Asthmaticus

Wheeler

Page

Shanley

2008

The Respiratory Tract in Pediatric Critical Illness and Injury

View full text Add to dashboard Cite

New Computerized Tomogram (CT) Indices for Pectus Excavatum: Tools for Assessing Modified Techniques for Asymmetry in Nuss Repair

Abstract: The results of our study indicate that extensive small airway abnormalities may be associated with NFA, and that these abnormalities are partially reversible after the successful control of asthma symptoms.

Cited by 36 publications

References 0 publications

High-Resolution Computed Tomography Evaluation of Peripheral Airways in Asthma Patients: Comparison of Focal and Diffuse Air Trapping

High-Resolution Computed Tomography Evaluation of Peripheral Airways in Asthma Patients: Comparison of Focal and Diffuse Air Trapping

Demonstration of the heterogeneous distribution of asthma in the lungs using CT and hyperpolarized helium‐3 MRI

Status Asthmaticus

Contact Info

Product

Resources

About