New concepts in liver preservation: How the pendulum sways back

Gulik, Thomas M. van

doi:10.1002/lt.21642

Cited by 11 publications

(7 citation statements)

References 21 publications

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“…Since this study involved the analysis of dimensions of blood vessels of embalmed human cadavers, concerns can be raised about how reflective these values are of the actual living population. Such concerns are most relevant when cadavers have been rapidly frozen resulting in shrinkage, 9,19,23 or rapidly filled with latex resulting in expansion of blood vessels. 6 In this study, an appropriate volume of a modified Larssen solution 2,16 was used for embalming which has been shown to prevent fragmentation of both soluble and non-soluble proteins, 9,11,20 and ensuring adequate fixation of lipids 5 and nucleic acids in cadavers.…”

Section: Discussionmentioning

confidence: 99%

“…Such concerns are most relevant when cadavers have been rapidly frozen resulting in shrinkage, 9,19,23 or rapidly filled with latex resulting in expansion of blood vessels. 6 In this study, an appropriate volume of a modified Larssen solution 2,16 was used for embalming which has been shown to prevent fragmentation of both soluble and non-soluble proteins, 9,11,20 and ensuring adequate fixation of lipids 5 and nucleic acids in cadavers. 5 This ensures that the linear non-load-deformation characteristic of blood vessels is maintained in cadavers.…”

Section: Discussionmentioning

confidence: 99%

“…The anterior divides into visceral branches that supply the pelvic organs and the parietal branches that supply the muscles of the gluteal region and upper thigh. 2,7,9 All the branches from the posterior division are parietal, and supply the ventral and dorsal aspects of the posterior abdominal wall and the gluteal region. 16 The UA is one of the visceral branches of the anterior division of the IIA.…”

Section: Blood Supply Of the Pelvic Cavitymentioning

confidence: 99%

“…8 The blood supply through the UA facilitates the growth of these fibroids, and hence a reduction of blood supply is utilized to reduce their size. 9 Therefore, arterial embolization of the UA is commonly employed as a preoperative adjunct or as an alternative to surgery in the treatment of uterine fibroids. 1,4,10 In addition, hysterectomies are often carried in post-menopausal women to manage large uterine fibroids or malignancies.…”

Section: Introductionmentioning

confidence: 99%

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A detailed study of the course, branching pattern and dimensions of the uterine and vaginal arteries and their branches

Chaudhuri

Lakshmi

et al. 2019

MOJAP

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Introduction: Despite the critical role of the uterine artery (UA) and vaginal artery (VA) in the blood supply to the pelvic organs and cavity, there is a paucity of descriptions of their origin, course, and dimensions. Aim:The aim of the study was to present a detailed account based on a cadaveric study on pelvic halves of 31 female embalmed cadavers belonging an Indian population.Methods: A total of 31 female cadavers (62 pelvic halves) in the age group of 34-75 years belonging an Indian population were dissected.Results: There were no variations in the origin, course, distribution and length of the UA and VA and their branches. However, in a significant number of cadavers, the diameter of the UA was smaller than normal, while the corresponding VA in these same cadavers was larger than normal. Additionally, in other cadavers where the diameter of the UA was larger than normal, the diameters of the VA was smaller than normal. Conclusion:Thus, uterus received complementary blood supply from the UA and VA. However, a more definitive pattern of blood supply to the uterus could not be established due to a limited number of cadavers. Further, since adequate studies from different population groups were not available, a more detailed description of the branching patterns and dimensions of the UA and VA and their branches in different population groups could not be formulated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Blood Supply Of the Pelvic Cavitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A detailed study of the course, branching pattern and dimensions of the uterine and vaginal arteries and their branches

Chaudhuri

Lakshmi

et al. 2019

MOJAP

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“…These reasons explain the rare use of ex situ resection to date. However, the procedure will be improved in the future along with the development of liver transplantation techniques such as perfusion technology, which has focused on protecting livers with impaired function and has achieved successful results [39,40]. …”

Section: Discussionmentioning

confidence: 99%

Ex situ Liver Resection for Unresectable Tumors

Lei

Liu²,

Liu³

et al. 2012

Dig Surg

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Primary and secondary liver tumors are among the most common tumors in humans. Two surgical approaches may be used to address these tumors: liver transplantation and liver resection. However, some tumors cannot be treated by conventional techniques or liver transplantation due to poor intraoperative exposure, limitations of indication standards, and/or other complex factors. To overcome these problems, ex situ liver resection has been introduced and used successfully in many cases. This technique is based primarily on liver transplantation and perfusion with preservation solution under hypothermic conditions. The major indications for ex situ liver resection are liver tumors that are unresectable or in which resection using conventional surgical techniques is very dangerous due to the close proximity to or involvement of the venous confluence and/or the main hepatic veins. However, high mortality and morbidity rates limit the use of this technique despite the efforts of many surgeons to improve their skills. Patient selection is of utmost importance to achieve a good outcome. Emphasis on basic research (e.g. on reperfusion injury) and the development of key techniques should improve the safety of the procedure and reduce mortality in the future.

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