New conjugated monomers and oligomers derived from chalcones and containing thiophene, pyrrole, and pyrimidine fragments

One‐potandtwo‐potmethods for chalcone derived pyrimidines synthesis and applications

“…[205] Ferrocenyl, having chalcones (56), chemically reacted with guanidine sulfate to get compound (58) with 55% yield for the next step with the insertion of 2,5-dimethoxytetrahydrofuran in acetic acid under 2 h reflux to obtain compound (59), these compounds have electrochemical properties. [206] Another heterochalcone (57) formed amino-pyrimidines (60) with 34% yield, which further form the pyrrole conjugated pyrimidines (61) with 19% yield [207] (Scheme 15). Small-scale air oxygen can cause oxidation of pyrimidine and form a mixture of products or side products that lead toward the tedious purification and lowering of yield.…”

1,4-Bis(thiophen-2-yl)butane-1,4-dione

“…For related structures, see: Becerra et al (2010); Liu et al (2008); Nair, Devipriya & Eringathodi (2007) ;Nair, Vellalath et al (2007); Bushueva et al (2010). For background information on applications, see: Atalar et al (2009); Chen et al (2009); Charati et al (2008); Cao et al (2008); Wu et al (2008).…”

“…Data collection: SMART (Bruker, 2007); cell refinement: SAINT (Bruker, 2007); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL. Electroactive and photoactive thiophene-based molecules, oligomers, and polymers (Atalar et al, 2009;Chen et al, 2009;Charati et al, 2008;Becerra et al, 2010;Liu et al, 2008;Nair, Devipriya & Eringathodi, 2007;Nair, Vellalath et al, 2007;Bushueva et al; are important for advanced technological applications, including display technologies, field-effect transistors, solar cells, sensors, nonlinear optics, molecular wires, and diodes (Cao et al, 2008;Wu et al, 2008). Thiophenes and its derivatives are originally applied to synthesize thiophene-based compounds, such as, oligomers and polythiophenes due to easy electropolymerization of thiophenes to produce stable, electrically conductive polymeric films.…”

Divergent Synthesis and Evaluation of the in vitro Cytotoxicity Profiles of 3,4‐Ethylenedioxythiophenyl‐2‐propen‐1‐one Analogues

“…established the synthesis of the γ‐butenolide natural product framework with epoxidation of 2‐propenone as a crucial step . Owing to their biological importance, nitrogen‐containing six‐membered pyrimidines and five‐membered isoxazoles were synthesized from chalcones by cyclocondensation reactions. Pyrimidines are basic components of nucleic acids, and substituted pyrimidines have exhibited excellent biological activity against various human cancer cell lines .…”

“…[8] Recently,G uo and co-workers developed an efficient synthesis of a,b-unsaturated carbonyl compounds by Fe II -mediated de-carboxylative cross-couplingr eactions, [9] whereas Correa et al established the synthesis of the g-butenolide natural product framework with epoxidation of 2-propenone as ac rucial step. [10] Owingt ot heir biological importance,n itrogen-containing six-membered pyrimidines [11] and five-membered isoxazoles were synthesized fromc halcones by cyclocondensation reactions. Pyrimidines are basic components of nucleic acids, and substituted pyrimidines have exhibited excellent biological activity against varioush uman cancerc ell lines.…”