New Cr, Mo, W, and Fe Metal Complexes with Potentially Heptadentate (S3N4) Tripodal Schiff Base Ligand: Synthesis, Characterization, and Antibacterial Activity

Rahmatabadi, Fatemeh Dashti; Khojasteh, Roya Ranjineh; Fard, Hassan Kabiri; Tadayon, Fariba

doi:10.1134/s1070363220070191

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…were tested against hepatocellular carcinoma cell lines (HepG-2 cells) for their antitumor activity in vitro. The imine ligand showed strong antitumor activity against the HepG-2 cells, but the activity of the synthesized iron complexes (38)(39)(40) was insignificant (Scheme 6, Table 1). Complex 37 showed an antitumor activity of 3.80 µg/mL against HepG-2, whilst the standard drug, Cisplatin, showed an activity of 3.27 µg/mL (Table 1) [31].…”

Section: Imine-iron Complexes As Anticancer Agentsmentioning

confidence: 99%

“…It had the highest antibacterial activity against B. cereus (29 mm) and S. aureus (14 mm), which was higher than the activity of the standard drug tetracycline against B. cereus (11 mm) and S. aureus (9 mm), but it showed moderate activity against E. coli (14 mm) and P. aeruginosa (14 mm), which was for both bacteria (Table 2). These recorded activities of the complexes are due to the more pronounced lipophilic nature of the metal centers in the complexes [40,41]. Scheme 8.…”

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confidence: 99%

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Iron–Imine Cocktail in Drug Development: A Contemporary Update

Anane,

Owusu,

Rivera

et al. 2024

IJMS

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Organometallic drug development is still in its early stage, but recent studies show that organometallics having iron as the central atom have the possibility of becoming good drug candidates because iron is an important micro-nutrient, and it is compatible with many biological systems, including the human body. Being an eco-friendly Lewis acid, iron can accept the lone pair of electrons from imino(sp2)-nitrogen, and the resultant iron–imine complexes with iron as a central atom have the possibility of interacting with several proteins and enzymes in humans. Iron–imine complexes have demonstrated significant potential with anticancer, bactericidal, fungicidal, and other medicinal activities in recent years. This article systematically discusses major synthetic methods and pharmacological potentials of iron–imine complexes having in vitro activity to significant clinical performance from 2016 to date. In a nutshell, this manuscript offers a simplistic view of iron complexes in medicinal inorganic chemistry: for instance, iron is presented as an “eco-friendly non-toxic” metal (as opposed to platinum) that will lead to non-toxic pharmaceuticals. The abundant literature on iron chelators shows that many iron complexes, particularly if redox-active in cells, can be quite cytotoxic, which can be beneficial for future targeted therapies. While we made every effort to include all the related papers, any omission is purely unintentional.

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Section: Imine-iron Complexes As Anticancer Agentsmentioning

confidence: 99%

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confidence: 99%

Iron–Imine Cocktail in Drug Development: A Contemporary Update

Anane,

Owusu,

Rivera

et al. 2024

IJMS

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“…Azomethine 244 (Figure 29) was prepared by condensation of thiophene‐2‐carboxaldehyde with tris(2‐aminoethyl)amine and the resulting heptadentate ligand was converted into complexes of transition metals. [ 222 ] Antibacterial evaluation through the disc diffusion method showed that chromium complex of 244 was the most potent in the series against E. coli and P. aeruginosa and more potent than tetracycline, gentamycin or chloramphenicol. On the contrary, iron complex of 244 was the most potent in the series against S. aureus and B. cereus and more potent than tetracycline or gentamycin.…”

Section: Antimicrobial Activity Of Metal Complexes Based On Thiophene...mentioning

confidence: 99%

Thiophene‐containing compounds with antimicrobial activity

Roman¹

2022

Archiv der Pharmazie

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Thiophene, as a member of the group of five-membered heterocycles containing one heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the accurate positioning of various functionalities onto the thiophene ring. This review provides a comprehensive, systematic and detailed account of the developments in the field of antimicrobial compounds featuring at least one thiophene ring in their structure, over the last decade.

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“…[21] Niloufar Akbarzadeh-T and colleagues synthesized nanoparticles of lanthanum oxide by a codeposition method and proved that the lanthanum oxide nanoparticle is a potent antibacterial agent. [22] Roya Ranjineh Khojasteh, [23] Ali Reza Rezvani, [24] and their colleagues found the antibacterial property of the complexes was greater than that of its ligand; meanwhile, the Co(II), Mn(II), Fe(II), Ni(II), and Cu(II) complexes showed antibacterial activity. However, the antibacterial experiment mostly used dimethyl sulfoxide (DMSO); these solvents are inherently cytotoxic can harm the environment.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of proton conduction between two new Cd(II) and Co(II) complexes and in vitro antibacterial study of the Cd(II) complex

Shi

et al. 2022

Applied Organom Chemis

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Two new complexes based on 4,4′‐[1,3‐phenylenebis(oxy)]diphthalic acid (H4L) ligands were synthesized, namely, [Cd2(L)(1,10‐phen)2(H2O)]n(1) and [Co2(L)(1,10‐phen)2(H2O)]n(2), in which 2D structures transform into 3D supramolecular structures by CH···π interaction. The proton conductivity of complexes 1 and 2 at low temperature is close (σ1 = 3.12 × 10−8 S cm−1 and σ2 = 3.81 × 10−8 S cm−1 at 30°C), but these two complexes show different conduction mechanisms. The Vehicular mechanism in 1 is caused by the O···H/H···O contact in 1, which is stronger than 2, and the Grotthuss mechanism in 2 is caused by the N···H/H···N contact in 2, which is stronger than 1. At the same time, complex 1 showed excellent antibacterial properties in vitro, mainly reflected in that five kinds of bacteria (Escherichia coli, Bacillus amyloliquefaciens, Pantoea agglomerans, Pseudomonas putida, and Pectobacterium carotovora) could play an obvious inhibitory effect in the concentration range of 20 μg·ml−1.

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New Cr, Mo, W, and Fe Metal Complexes with Potentially Heptadentate (S3N4) Tripodal Schiff Base Ligand: Synthesis, Characterization, and Antibacterial Activity

Cited by 6 publications

References 24 publications

Iron–Imine Cocktail in Drug Development: A Contemporary Update

Iron–Imine Cocktail in Drug Development: A Contemporary Update

Thiophene‐containing compounds with antimicrobial activity

A comparative study of proton conduction between two new Cd(II) and Co(II) complexes and in vitro antibacterial study of the Cd(II) complex

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