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This is the first study of the antibacterial activity of heptadentate Schiff base ligand (trensal) and its Cr(III), Co(III), Ni(II), and Mn(III) complexes that have been synthesized from the heptadentate Schiff base ligand derived from salicylaldehyde and tris(2-aminoethyl)amine. Heptadentate Schiff base ligand and its complexes were characterized by elemental analysis, 1 H and 13 C NMR, IR, and UV-Vis spectroscopy. The products were tested in vitro against the bacterial species, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Bacillus cereus by disc diffusion and micro-broth dilution methods. All compounds demonstrated potent antibacterial activity higher than the Schiff base ligand. Staphylococcus aureus was the most susceptible bacterial species to Co(III) complex while Escherichia coli and Pseudomonas aeruginosa required a relatively higher minimum inhibition concentrations of Cr(III) and Ni(II) complexes. Co(III) complex was the most potent inhibitor against Pseudomonas aeruginosa. Mn(III) complex was active against Pseudomonas aeruginosa.

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