Synthesis, characterization, and antibacterial activities of some metal complexes of heptadentate schiff base ligand derived from acetylacetone

Khojasteh, Roya Ranjineh; Matin, Sara Jalali

doi:10.1134/s107042721506004x

Cited by 12 publications

(3 citation statements)

References 19 publications

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“…In the biological field, there are more attempts to create novel transition metal complexes. Novel chemotherapeutic medicines must be created because many pathogenic germs have become resistant to already available antibacterial medications [6,7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic, Computational Structure Analysis, Molecular Docking, in vitro Antibacterial and in vivo Antipyretic Investigations of Transition Metal(II) Complexes

Yogalakshmi,

Banumathi

2023

ajc

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Unsymmetrical Schiff base hydrazone complexes of cobalt(II), nickel(II) and zinc(II) were synthesized from oxalic dihydrazide, salicylaldehyde and ethyl acetoacetate. The ligand and its metal(II) complexes were characterized by elemental analysis, UV-visible, FT-IR, molar conductivity. To determine the biological activity, in vivo antipyretic as well as in vitro antibacterial activities were conducted along with molecular docking simulation, HOMO-LUMO and MEP calculations. The findings from the experimental and molecular docking investigations demonstrated that the ligand and all the metal(II) complexes has an ability to interact with E. coli 24kDa domain protein (PDB: 1KZN). Furthermore, these interactions were accompanied by favourable docking score values, indicating potential therapeutic implications. The quantum parameters and geometric optimization of the ligand and complexes were performed using DFT simulations.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic, Computational Structure Analysis, Molecular Docking, in vitro Antibacterial and in vivo Antipyretic Investigations of Transition Metal(II) Complexes

Yogalakshmi,

Banumathi

2023

ajc

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“…Synthesis, characterization of Schiff bases have remained studied is proved that C=N linkage in Schiff bases is an essential part for bioactivity [10]. Schiff bases are significant in many fields, and great assortment in their varied biological activities [11][12][13]. Their role as antimicrobials, and other biological activities like anticancer, antioxidant, anti-tumor and…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Antifungal Activities, Aspergillus Niger, Aspergillus Flavus, Candida Albicans of Novel Schiff Base and Schiff Based Resin

2021

SBB

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This work studies the synthesis of a novel Schiff base bis (2-methoxy-1-napthaldehyde) hydrazine hydrate and Schiff based resin poly methylene bis (2-methoxy-1-napthaldehyde) hydrazine hydride via-condensation procedure using with formaldehyde (HCHO) at temperature 70 to 80 °C for 3-4 hours. The synthesized Schiff base BMNHH and resin PMBMNHH were recrystallized from methanol resulting pure compounds. The synthesized compounds were characterized by (CHN), (FT-IR) Thermo Gravimetric Analysis (TGA), EDS analysis and Scanning Electron Microscopy (SEM), Powder X-Ray Diffraction Analysis (XRD). The all results of analytical techniques successfully approved the structure and morphology of newly prepared Schiff base and Schiff based resin. After the characterization the synthesized compounds BMNHH and PMBMNHH was screened against Gram-negative antifungal strains such as, Aspergillus Niger (Gram-negative) Aspergillus flavus (Gram-negative), Candida albicans (Gram-negative) through Agar well diffusion method. The found results conveyed that the tested compounds indicated good sensitivity and enhanced activity against Gram-negative antifungal strains [1,2].

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“…While there are already several classes of antibacterial agents, there has been some considerable emerging resistance in most pathogenic bacteria to these drugs [18]. For prevention of this serious medical problem, it is necessary to develop some new antibacterial agents or to expand the bioactivity of the previously used drugs [19,20]. Metal-based antibacterial compounds seem to be a promising research for designing a novel therapeutic methodology for new antibiotic drugs to control and prevent the growth of bacterial strains [21,22].…”

Section: Introductionmentioning

confidence: 99%

Cobalt (II) Complexes with Schiff Base Ligands Derived from Terephthalaldehyde and ortho-Substituted Anilines: Synthesis, Characterization and Antibacterial Activity

et al. 2018

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In this study, N-propyl-benzoguanamine-SO 3 H magnetic nanoparticles (MNPs) were used as a catalyst for the synthesis of new Schiff base ligands from condensation reaction of terephthalaldehyde and ortho-aniline derivatives. The bioactive ligands and their cobalt (II) complexes were characterized with nuclear magnetic resonance ( 1 H-NMR), Fourier-transform infrared spectroscopy (FT-IR), ultraviolet-visible (UV-Visible), mass spectroscopy studies and molar conductance. The antibacterial activity of ligands and their metal complexes were screened using disc diffusion and broth dilution methods against Escherichia coli, Serratia marcescens, Pseudomonas aeruginosa (gram negative bacteria), Bacillus Subtilis and Staphylococcus aureus (gram positive bacteria). The ligands with hydroxyl group showed better biological activity when compared to other ligands. The results showed that the metal complexes have much higher antibacterial activity compare to the parent ligands. It was found that the CoL 3 complex was more effective than other metal complexes used against all types of bacteria tested and it was more effective against Pseudomonas aeruginosa with diameter inhibition zone of 17 mm and minimal inhibitory concentration value of 0.15 mg/mL.

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Synthesis, characterization, and antibacterial activities of some metal complexes of heptadentate schiff base ligand derived from acetylacetone

Cited by 12 publications

References 19 publications

Synthesis, Spectroscopic, Computational Structure Analysis, Molecular Docking, in vitro Antibacterial and in vivo Antipyretic Investigations of Transition Metal(II) Complexes

Synthesis, Spectroscopic, Computational Structure Analysis, Molecular Docking, in vitro Antibacterial and in vivo Antipyretic Investigations of Transition Metal(II) Complexes

Synthesis, Characterization and Antifungal Activities, Aspergillus Niger, Aspergillus Flavus, Candida Albicans of Novel Schiff Base and Schiff Based Resin

Cobalt (II) Complexes with Schiff Base Ligands Derived from Terephthalaldehyde and ortho-Substituted Anilines: Synthesis, Characterization and Antibacterial Activity

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