New cycloartanes and new iridoids from Dolichandrone spathacea collected in the mangrove forest of Soc Trang province, Vietnam

Abstract

Two new cycloartanes, named dolichandrone A (1) and dolichandrone B (2), as well as two new iridoids, named [6-O-[(E)-4-methoxycinnamoyl]-1β-hydroxy-dihydrocatalpolgenin (3) and 6-O-[(E)-4-methoxycinnamoyl]-1α-hydroxy-dihydrocatalpolgenin (4), together with four known iridoids (5-8), were isolated from the leaves and barks of Dolichandrone spathacea. Their structures were elucidated by means of extensive analysis of their HRESIMS, 1D and 2D NMR spectroscopic data. All of these compounds have been isolated for the first time from this plant. Compounds 1, 2, 5, and 7 were evaluated for their cytotoxic activity in vitro against four human cancer cell lines KB, Lu, HepG2, and MCF7. The results showed that only compound 2 exhibited a good cytotoxicity against KB cell line with IC of 18.77 μM.

Isolation, semi-synthesis, docking-based prediction, and bioassay-based activity of Dolichandrone spathacea iridoids: new catalpol derivatives as glucosidase inhibitors

“…The procedures for the isolation of 1, 2, 13 and 14 were described in ref. 22 . Iridoid 1 and 14 were isolated from the leaves, while 2 and 13 were isolated from the barks of Dolichandrone spathacea collected in Soc Trang province, Vietnam.…”

“…Our previous study on chemical constituents of the mangrove plant Dolichandrone spathacea led to the isolation of four catalpol iridoids. 22 This seems reasonable because according to folk experiences, the plant is currently reported as a natural symptom reliever for diabetes, especially in Mekong Delta, Vietnam. Nevertheless, its chemical properties and medical potentiality still remain almost untouched possibly because of their narrow distribution.…”

Xanthine oxidase inhibition study of isolated secondary metabolites from Dolichandrone spathacea (Bignoniaceae): In vitro and in silico approach

“…The leaves are utilized in treating laxative issues, thrush, asthma, and are being investigated for their potential as antitumor and antiseptic agents. The seeds exhibit disinfectant properties, and the stems are employed in traditional medicine to treat bronchitis ( Jackes, 2017 , Nguyen et al, 2018 , Van Tuan et al, 2018 ). The phytochemical constituents of this plant were investigated, revealing saponins, flavonoids, phenylethanoid glycosides, iridoids, triterpenoids, steroids, and phenolics constitute the primary bioactive constituents ( Nguyen et al, 2016 , Thao et al, 2021 ).…”

“…The phytochemical constituents of this plant were investigated, revealing saponins, flavonoids, phenylethanoid glycosides, iridoids, triterpenoids, steroids, and phenolics constitute the primary bioactive constituents ( Nguyen et al, 2016 , Thao et al, 2021 ). Earlier pharmacological studies have shown that it exhibits antioxidant and anti-hyperglycemic effects ( Kaewpiboon et al, 2012 , Van Tuan et al, 2018 ) and antimicrobial activity ( Saiful et al, 2011 , Nguyen et al, 2018 ). However, the XO-inhibiting components in D. spathacea have not been reported and identified previously.…”

Population Status of the Endangered Semi-Mangrove Dolichandrone spathacea on Hainan Island, China

“…As an excellent coastal shelterbelt mangrove species, D. spathacea possesses various medicinal, economic, and ecological values [18]. For example, the leaves of this traditional medicinal plant have been widely used as a tonic, as well as an emmenagogue for post-partum females [19]; their juice can also cure oral thrush, flatulence, and bronchitis [20,21]. Its bark can be used as laxative and for treatment of allergies [22].…”