New cytotoxic dihydrochalcone and steroidal saponins from the aerial parts of Sansevieria cylindrica Bojer ex Hook

Raslan, Mona; Melek, F. R.; Said, Ataa; Elshamy, Abdelsamed I.; Umeyama, Akemi; Mounier, Marwa M.

doi:10.1016/j.phytol.2017.08.004

Cited by 13 publications

(14 citation statements)

References 17 publications

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“…Previous phytochemical studies reported the isolation of steroidal saponins [11,[13][14][15][16], dihydrochalcones [16] and sappanin-type homoisoflavonoids [17] from S. trifasciata aerial parts. Several steroidal sapogenins, saponins, homoisoflavonoids, flavonoids and dihydrochalcones were formerly isolated from other Sansevieria species [18][19][20][21][22][23]. Sansevieria trifasciata was reported to possess analgesic, anti-inflammatory, antipyretic [24], antidiabetic [25], antiallergic [26] and thrombolytic activities [27].…”

Section: Introductionmentioning

confidence: 99%

Metabolomic profiling of Sansevieria trifasciata hort ex. Prain leaves and roots by HPLC-PAD-ESI/MS and its hepatoprotective effect via activation of the NRF2/ARE signaling pathway in an experimentally induced liver fibrosis rat model

et al. 2021

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Sansevieria species show various bioactivities. Nevertheless, its therapeutic prospect in liver fibrosis even now is uninvestigated. The present study was conducted to analyze the metabolomic profile of Sansevieria trifasciata hort ex. Prain leaves and roots via HPLC-PAD-ESI/MS and evaluation of its hepatoprotective effect. The identified phytoconstituents were mainly steroidal saponins, phenolics and terpenoids. Sixty-one compounds were tentatively identified in StLE and fifty-nine compounds in StRE. Thioacetamide-induced liver fibrosis rat model was used to evaluate the hepatoprotective effect of Sansevieria trifasciata extracts via activation of the NRF2/ARE signaling pathway. Measurements of serum alanine transaminase (ALT), aspartate transaminase (AST) and malondialdehyde (MDA) were significantly decreased in treated groups with StLE and StRE (at doses of 200 and 100 mg/kg/day) compared with the TAA group. Also, the levels of reduced glutathione (GSH) content and hepatic mRNA levels of Nrf2, HO-1, NQO-1 and Keap-1 were markedly elevated. The prominent hepatoprotective effect was shown in StRE treated groups. Histological findings further confirmed the protective role of the plant against TAA-induced liver fibrosis. In conclusion, the abovementioned results indicated that the hepatoprotective mechanism of StLE and StRE could be achieved by activating Nrf2-ARE signaling pathways to alleviate oxidative stress and inflammation.

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Section: Introductionmentioning

confidence: 99%

Metabolomic profiling of Sansevieria trifasciata hort ex. Prain leaves and roots by HPLC-PAD-ESI/MS and its hepatoprotective effect via activation of the NRF2/ARE signaling pathway in an experimentally induced liver fibrosis rat model

et al. 2021

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“…The residue E from the EtOAc subextract of the MeOH extract of S. cylindrica rhizomes was subjected to flash column chromatography over octadecylsilanized silica gel (ODS) followed by repeated semipreparative HPLC separations to afford ten known compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). The physical and spectroscopic data of 1-10 nicely matched those reported in the literature.…”

Section: Resultsmentioning

confidence: 60%

“…Sansevieria plants have been reported to be rich in steroidal sapogenins and saponins. Previous phytochemical investigations of leaves and aerial parts of S. cylindrica led to the isolation of steroidal saponins [3][4][5], one of which demonstrated inhibition of capillary permeability activity [3], whereas others exhibited moderate cytotoxicities in vitro [4,5]. In addition, (+)-trifasciatine B, with high radical scavenging activity activity [4], and dihydrochalcone (+)-trifasciatine C [5,6], showing a moderate cytotoxicity against MCF7 cells, were isolated.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Constituents from the Rhizomes of Sansevieria cylindrica

Aung¹,

Aye²,

Thu³

et al. 2020

Rec.Nat.Prod.

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Analysis of the MeOH extract of rhizomes of Sansevieria cylindrica using repeated silica gel and reversed-phase chromatographic separations led to the isolation of ten known phenolic compounds (1-10) belonging to five different classes. Their structures, including the absolute configuration, were identified by NMR and CD spectra analysis. The antiradical activity of isolated compounds was screened using the DPPH scavenging method. The cytotoxic effects were assayed against a Hela cell line. Compounds 2-10 have been isolated from a Sansevieria species for the first time and compounds 5, 7-10 have been isolated from species of the Asparagaceae family for the first time. The structure of a homoisoflavanone isolated from S. roxburghiana has been revised.

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“…In addition to ornamental uses, the whole plant is used in Myanmar traditional medicine for treating cuts, sprains, and broken bones, whereas the roots are used to cure snakebites. The hydroxy methyldihydrochalcone (1,2-seco-homoisoflavanone) (+)-2 ,4 -dihydroxy-3 -methoxy-3,4-methylene dioxy-8-hydroxymethyldihydrochalcone, named (+)-(8S)-trifasciatine C (114), was isolated from the aerial parts of S. cylindrica [80]. It showed moderate cytotoxic effects against human breast adenocarcinoma (MCF7) cells.…”

Section: Colorants Of Dragon's Blood Resinsmentioning

confidence: 99%

“…More interesting is the isolation of enantiomeric compounds from different parts of the same plant. Thus, (+)-(8S)-trifasciatine C (114) was isolated from aerial parts of S. cylindrica [80], while the (8R)-enantiomer (115) was isolated from rhizomes [82]. Two different biosynthetic routes have been proposed to explain the formation of such antipodal flavonoids.…”

Section: Chemical Structures and Chemotaxonomic Considerationsmentioning

confidence: 99%

Flavonoids and Stilbenoids of the Genera Dracaena and Sansevieria: Structures and Bioactivities

Thu¹,

Myo²,

Aung

et al. 2020

Molecules

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The genera Dracaena and Sansevieria (Asparagaceae, Nolinoideae) are still poorly resolved phylogenetically. Plants of these genera are commonly distributed in Africa, China, Southeast Asia, and America. Most of them are cultivated for ornamental and medicinal purposes and are used in various traditional medicines due to the wide range of ethnopharmacological properties. Extensive in vivo and in vitro tests have been carried out to prove the ethnopharmacological claims and other bioactivities. These investigations have been accompanied by the isolation and identification of hundreds of phytochemical constituents. The most characteristic metabolites are steroids, flavonoids, stilbenes, and saponins; many of them exhibit potent analgesic, anti-inflammatory, antimicrobial, antioxidant, antiproliferative, and cytotoxic activities. This review highlights the structures and bioactivities of flavonoids and stilbenoids isolated from Dracaena and Sansevieria.

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New cytotoxic dihydrochalcone and steroidal saponins from the aerial parts of Sansevieria cylindrica Bojer ex Hook

Cited by 13 publications

References 17 publications

Metabolomic profiling of Sansevieria trifasciata hort ex. Prain leaves and roots by HPLC-PAD-ESI/MS and its hepatoprotective effect via activation of the NRF2/ARE signaling pathway in an experimentally induced liver fibrosis rat model

Metabolomic profiling of Sansevieria trifasciata hort ex. Prain leaves and roots by HPLC-PAD-ESI/MS and its hepatoprotective effect via activation of the NRF2/ARE signaling pathway in an experimentally induced liver fibrosis rat model

Bioactive Constituents from the Rhizomes of Sansevieria cylindrica

Flavonoids and Stilbenoids of the Genera Dracaena and Sansevieria: Structures and Bioactivities

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