New daphnane diterpenoidal 1,3,4-oxdiazole derivatives as potential anti-hepatoma agents: Synthesis, biological evaluation and molecular modeling studies

Wang, Xinyi; Wang, Yujue; Liu, Zijian; Zhao, Hongwei; Yao, Guo-Dong; Liu, Qingbo; Song, Shao-Jiang

doi:10.1016/j.bioorg.2024.107208

Bioorganic Chemistry

2024

DOI: 10.1016/j.bioorg.2024.107208

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New daphnane diterpenoidal 1,3,4-oxdiazole derivatives as potential anti-hepatoma agents: Synthesis, biological evaluation and molecular modeling studies

Xinyi Wang,

Yujue Wang,

Zijian Liu

et al.

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Cited by 3 publications

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13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1

Wang,

Guo

et al. 2024

Bioorganic Chemistry

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13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1

Wang,

Guo

et al. 2024

Bioorganic Chemistry

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Substituent effects on axial chiral compound enantiomers: synthesis and crystal structures of axially chiral 1,3,4-oxadiazole thioethers (Sulfones) based on 2,2′-bipyridine

Xiong,

Wang,

Shen

et al. 2025

Journal of Molecular Structure

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Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review)

Li,

Hao,

et al. 2024

Int J Oncol

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The Hippo signaling pathway plays a pivotal role in regulating cell growth and organ size. Its regulatory effects on hepatocellular carcinoma (HCC) encompass diverse aspects, including cell proliferation, invasion and metastasis, tumor drug resistance, metabolic reprogramming, immunomodulatory effects and autophagy. Yes-associated protein 1 (YAP1), a potent transcriptional coactivator and a major downstream target tightly controlled by the Hippo pathway, is influenced by various molecules and pathways. The expression of YAP1 in different cell types within the liver tumor microenvironment exerts varying effects on tumor outcomes, warranting careful consideration. Therefore, research on YAP1-targeted therapies merits attention. This review discusses the composition and regulation mechanism of the Hippo/YAP1 signaling pathway and its relationship with HCC, offering insights for future research and cancer prevention strategies.

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New daphnane diterpenoidal 1,3,4-oxdiazole derivatives as potential anti-hepatoma agents: Synthesis, biological evaluation and molecular modeling studies

Cited by 3 publications

References 30 publications

13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1

13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1

Substituent effects on axial chiral compound enantiomers: synthesis and crystal structures of axially chiral 1,3,4-oxadiazole thioethers (Sulfones) based on 2,2′-bipyridine

Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review)

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