New Delhi metallo-beta-lactamase-1-producing Acinetobacter spp. infection: report of a survivor

Schuelter-Trevisol, Fabiana; Schmitt, Graciane Jacinta; Araújo, Jane Martins de; Souza, Liliane Braga de; Nazário, Juliana Gomes; Januário, Raquel Landuchi; Mello, Rogério Sobroza de; Trevisol, Daisson José

doi:10.1590/0037-8682-0150-2015

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…The emergence of NDM-expressing enterobacteria [ 171 ] and Klebsiella [ 172 , 173 ] was then reported from all continents, but it recently reappeared in Italy (Toscana, Z. Koncz, personal communication). There are publications on NDM 1 expressing Acinetobacter [ 174 ], Pseudomonas [ 175 ], and only one E. coli publication [ 105 ]. It has never been found in Gram-positive bacteria.…”

Section: Resistance Problems Related To Gram-negative Pathogensmentioning

confidence: 99%

Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review

Fodor

Abate²,

Deák

et al. 2020

Pathogens

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Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are discussed. Arguments for, and against, pessimistic forecasts on a fatal “post-antibiotic era” are evaluated. In commensal niches, the appearance of a new antibiotic resistance often reduces fitness, but compensatory mutations may counteract this tendency. The appearance of new antibiotic resistance is frequently accompanied by a collateral sensitivity to other resistances. Organisms with an expanding open pan-genome, such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae, can withstand an increased number of resistances by exploiting their evolutionary plasticity and disseminating clonally or poly-clonally. Multidrug-resistant pathogen clones can become predominant under antibiotic stress conditions but, under the influence of negative frequency-dependent selection, are prevented from rising to dominance in a population in a commensal niche. Antimicrobial peptides have a great potential to combat multidrug resistance, since antibiotic-resistant bacteria have shown a high frequency of collateral sensitivity to antimicrobial peptides. In addition, the mobility patterns of antibiotic resistance, and antimicrobial peptide resistance, genes are completely different. The integron trade in commensal niches is fortunately limited by the species-specificity of resistance genes. Hence, we theorize that the suggested post-antibiotic era has not yet come, and indeed might never come.

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Section: Resistance Problems Related To Gram-negative Pathogensmentioning

confidence: 99%

Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review

Fodor

Abate²,

Deák

et al. 2020

Pathogens

View full text Add to dashboard Cite

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NDM-1-encoding plasmid in Acinetobacter chengduensis isolated from coastal water

Corrêa

Kraychete

Rezende

et al. 2021

Infection, Genetics and Evolution

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Synergistic Effects of Capric Acid and Colistin against Colistin-Susceptible and Colistin-Resistant Enterobacterales

et al. 2022

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Colistin is a last-line antibiotic against Gram-negative pathogens. However, the emergence of colistin resistance has substantially reduced the clinical effectiveness of colistin. In this study, synergy between colistin and capric acid was examined against twenty-one Gram-negative bacterial isolates (four colistin-susceptible and seventeen colistin-resistant). Checkerboard assays showed a synergistic effect against all colistin-resistant strains [(FICI, fractional inhibitory concentration index) = 0.02–0.38] and two colistin-susceptible strains. Time–kill assays confirmed the combination was synergistic. We suggest that the combination of colistin and capric acid is a promising therapeutic strategy against Gram-negative colistin-resistant strains.

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New Delhi metallo-beta-lactamase-1-producing Acinetobacter spp. infection: report of a survivor

Cited by 3 publications

References 11 publications

Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review

Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review

NDM-1-encoding plasmid in Acinetobacter chengduensis isolated from coastal water

Synergistic Effects of Capric Acid and Colistin against Colistin-Susceptible and Colistin-Resistant Enterobacterales

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