New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y₂) isolated from the South China Sea

Abstract

SummaryThree new depsidones, botryorhodines E–G (1–3), and two new isoindolinones, meyeroguillines A and B (7 and 9), along with five known compounds were isolated from an endophytic fungus Meyerozyma guilliermondii, derived from the mangrove plant Kandelia obovata. Their structures were elucidated by 1D and 2D NMR spectroscopy and high resolution mass spectrometry (HREIMS). Compounds 1–6 exhibited strong α-glucosidase inhibitory activity with IC50 values ranging from 2.1 to 13.3 μM. Moreover, kinetic studies of compounds 2 and 6 showed that both of them were noncompetitive inhibitors of α-glucosidase.

New furoisocoumarins and isocoumarins from the mangrove endophytic fungus Aspergillus sp. 085242

“…Analogously as described in reference [12]. Melting points were determined with a Fisher-Johns hot-stage apparatus apparatus and are uncorrected.…”

“…Analogously as described in reference [12] the fungus was grown on autoclaved rice solid substrate medium (thirty 500 mL Erlenmeyer flasks, each containing 50 g rice and 50 mL 3‰ of saline water) at room temperature under static conditions and daylight for 28 days. Following incubation, the mycelia and solid rice medium were extracted with MeOH three times.…”

Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2

“…In the past decades, our research group had been focusing on the exploration of new bioactive metabolites from mangrove endophytic fungi collected from the South China Sea [6,7,8,9,10,11,12,13]. The EtOAc extract of the fermentation of a mangrove endophytic fungus, Penicillium sp.…”

Natural Products from Diaporthe arecae with Anti‐Angiogenic Activity

“…Finally, a new compound, arecine (1), together with twenty known diketopiperazines, cordysinin A (2), [17] cyclo(l-Thr-l-Pro) (3), [18] cyclo(6-hydroxy-Pro-l-Leu) (4), [19] cyclo(l-Val-l-Pro) (5), [20] bacillusamide B (6), [21] cyclo(l-Leu-l-Pro) (7), [20] cyclo(l-Val-l-Ala) (8), [22] cyclo(l-Leu-l-Ala) (9), [23] cyclo(l-Ile-l-Ala) (10), [22] cyclo(Gly-l-Val) (11), [24] cyclo(Gly-l-Leu) (12), [25] cyclo(Gly-l-Ile) (13), [26] cyclo(l-Ile-d-Pro) (14), [27] staphyloamide A (15), [19] cyclo(l-Ala-l-Pro) (16), [20] cyclo(l-Ser-l-Pro) (17), [28] cyclo(l-Trp-l-Pro) (18), [29] cyclo(l-Tyr-l-Pro) (19), [30] cyclo(l-Phe-l-Ala) (20), [31] and cyclo(l-Ser-l-Phe) (21) [32] were identified. On the other hand, the fungus D. arecae was also cultured by the PDB condition with 10 % NaCl in room temperature for two weeks.…”