New developments in intrauterine drug delivery systems and devices

Urbán-Morlán, Zaida; Serrano-Mora, Luis Eduardo; Martínez-Acevedo, Lizbeth; Leyva‐Gómez, Gerardo; Mendoza‐Muñoz, Néstor; Quintanar‐Guerrero, David

doi:10.1016/b978-0-12-819838-4.00018-3

Cited by 3 publications

(4 citation statements)

References 86 publications

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“…The primary uses of nanomedicine are in image processing, disease diagnosis, tissue engineering, and the creation of more efficient, safe, and affordable drug delivery systems (DDS) to deliver drugs precisely to target sites, which can shorten the duration of treatment by reducing toxicities and off‐target effects 55 . Additionally, by regulating the frequency, timing, and site of release, DDS is a formulation or instrument that facilitates the intake of a medicinal compound, improving both its efficacy and safety 56 . Recently, notable progress has been made in the realm of delivery systems designed to transport therapeutic agents or naturally derived active substances to specific sites within the body, with the aim to treat a wide range of disorders 57 .…”

Section: Issues Of Concerns Regarding Chemotherapymentioning

confidence: 99%

“… 55 Additionally, by regulating the frequency, timing, and site of release, DDS is a formulation or instrument that facilitates the intake of a medicinal compound, improving both its efficacy and safety. 56 Recently, notable progress has been made in the realm of delivery systems designed to transport therapeutic agents or naturally derived active substances to specific sites within the body, with the aim to treat a wide range of disorders. 57 Several successful DDS developments have taken place in recent years; nevertheless, to successfully distribute drugs to their intended places, there are still several challenges that must be overcome and advanced technologies developed.…”

Section: Issues Of Concerns Regarding Chemotherapymentioning

confidence: 99%

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Nanoplatforms: The future of oral cancer treatment

Senevirathna

Jayawickrama

Jayasinghe

et al. 2023

Health Science Reports

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Background and AimsCytotoxicity is a key disadvantage of using chemotherapeutic drugs to treat cancer. This can be overcome by encapsulating chemotherapeutic drugs in suitable carriers for targeted delivery, allowing them to be released only at the cancerous sites. Herein, we aim to review the recent scientific developments in the utilization of nanotechnology‐based drug delivery systems for treating oral malignancies that can lead to further improvements in clinical practice.MethodsA comprehensive literature search was conducted on PubMed, Google Scholar, ScienceDirect, and other notable databases to identify recent peer‐reviewed clinical trials, reviews, and research articles related to nanoplatforms and their applications in oral cancer treatment.ResultsNanoplatforms offer a revolutionary strategy to overcome the challenges associated with conventional oral cancer treatments, such as poor drug solubility, non‐specific targeting, and systemic toxicity. These nanoscale drug delivery systems encompass various formulations, including liposomes, polymeric nanoparticles, dendrimers, and hydrogels, which facilitate controlled release and targeted delivery of therapeutic agents to oral cancer sites. By exploiting the enhanced permeability and retention effect, Nanoplatforms accumulate preferentially in the tumor microenvironment, increasing drug concentration and minimizing damage to healthy tissues. Additionally, nanoplatforms can be engineered to carry multiple drugs or a combination of drugs and diagnostic agents, enabling personalized and precise treatment approaches.ConclusionThe utilization of nanoplatforms in oral cancer treatment holds significant promise in revolutionizing therapeutic strategies. Despite the promising results in preclinical studies, further research is required to evaluate the safety, efficacy, and long‐term effects of nanoformulations in clinical settings. If successfully translated into clinical practice, nanoplatform‐based therapies have the potential to improve patient outcomes, reduce side effects, and pave the way for more personalized and effective oral cancer treatments.

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Section: Issues Of Concerns Regarding Chemotherapymentioning

confidence: 99%

Section: Issues Of Concerns Regarding Chemotherapymentioning

confidence: 99%

Nanoplatforms: The future of oral cancer treatment

Senevirathna

Jayawickrama

Jayasinghe

et al. 2023

Health Science Reports

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“…Interestingly, unlike the other mucosal drug delivery routes, uterine drug absorption does not depend upon the ionisation of a drug. Rather, absorption is driven by the charge of the drug, making the uterus selectively permeable to drugs that are negatively charged or possess a lower overall net charge, while also being readily permeable to high-molecular-weight (MW) drugs [ 70 ].…”

Section: Vaginal Drug Delivery Systems: History and Present Therapeuticsmentioning

confidence: 99%

Application of Sol–Gels for Treatment of Gynaecological Conditions—Physiological Perspectives and Emerging Concepts in Intravaginal Drug Delivery

Thapa

Gurung

Parat

et al. 2022

Gels

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Approaches for effective and sustained drug delivery to the female reproductive tract (FRT) for treating a range of gynaecological conditions remain limited. The development of versatile delivery platforms, such as soluble gels (sol–gels) coupled with applicators/devices, holds considerable therapeutic potential for gynaecological conditions. Sol–gel systems, which undergo solution-to-gel transition, triggered by physiological conditions such as changes in temperature, pH, or ion composition, offer advantages of both solution- and gel-based drug formulations. Furthermore, they have potential to be used as a suitable drug delivery vehicle for other novel drug formulations, including micro- and nano-particulate systems, enabling the delivery of drug molecules of diverse physicochemical character. We provide an anatomical and physiological perspective of the significant challenges and opportunities in attaining optimal drug delivery to the upper and lower FRT. Discussion then focuses on attributes of sol–gels that can vastly improve the treatment of gynaecological conditions. The review concludes by showcasing recent advances in vaginal formulation design, and proposes novel formulation strategies enabling the infusion of a wide range of therapeutics into sol–gels, paving the way for patient-friendly treatment regimens for acute and chronic FRT-related conditions such as bacterial/viral infection control (e.g., STDs), contraception, hormone replacement therapy (HRT), infertility, and cancer.

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“…In medical therapeutics, drug delivery systems (DDSs) are paramount, ensuring the efficacious conveyance of medicinal agents into the body, thereby enhancing treatment effectiveness and safety. [1][2][3][4][5] By orchestrating the pace, temporal dynamics, and site of drug release, DDSs outperform conventional administration methods, circumventing dissolution, and initial metabolic processes. This, in turn, holds the promise of diminishing drug dosages and mitigating potential hepatotoxic repercussions.…”

Section: Introductionmentioning

confidence: 99%

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

Valladão,

da Silva,

Souza

2024

Macromolecular Symposia

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The present investigation offers a thorough bibliometric exploration spotlighting the pivotal utilization of zinc oxide nanostructures, encompassing both zero‐dimensional (0D) nanoparticles and one‐dimensional (1D) nanostructures, within the realm of nanotechnology‐driven drug delivery systems. This analysis particularly illuminates the distinctive potential of these nanostructures in the cancer therapy context, not merely as carriers and deliverers of pharmaceutical agents, but as entities capable of selectively inducing apoptosis in cancer cells through the orchestrated generation of reactive oxygen species (ROS). Recent research endeavors notably underscore the application prospects of ZnO nanostructures in domains like DNA cleavage, bioimaging, and agricultural defense mechanisms. Moreover, the study elucidates the pronounced enhancement in solubility and biocompatibility that these nanostructures bring about when harmoniously integrated into polymeric nanocomposites. Concomitantly, the involvement of polymers in this symbiotic system is unveiled, wherein they play a multifaceted role in dictating release selectivity, thereby facilitating targeted and efficacious interactions with tissues. Functionally engineered polymeric nanocomposites emerge as promising candidates for targeted delivery modalities in cancer treatment, demonstrating an affinity for specific cell receptors and exhibiting enhanced cellular uptake within the size range of 100–200 nm. The study unearths robust associations among pivotal research terminologies through an exhaustive analysis of Link Strength Between Items (LSBI), culminating in the presentation of a cogent map delineating the evolving trends and forthcoming trajectories in this dynamic domain. In summation, this all‐encompassing bibliometric inquiry serves as a poignant testament to the prodigious potential of zinc oxide nanostructures in the realm of forthcoming nanotechnology‐driven drug delivery paradigms.

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New developments in intrauterine drug delivery systems and devices

Cited by 3 publications

References 86 publications

Nanoplatforms: The future of oral cancer treatment

Nanoplatforms: The future of oral cancer treatment

Application of Sol–Gels for Treatment of Gynaecological Conditions—Physiological Perspectives and Emerging Concepts in Intravaginal Drug Delivery

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

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