New dihydrochromene and xanthone derivatives from Lisotrigona furva propolis

Oanh, Vũ Thị Kim; Thoa, Ha Thi; Hang, Nguyen Thi Minh; Phuong, Diep Thi Lan; Liên, Nguyễn Thị Kim; Popova, Milena; Trusheva, Boryana; Bankova, Vassya; Le, Thanh Nguyen

doi:10.1016/j.fitote.2020.104821

Cited by 16 publications

(30 citation statements)

References 33 publications

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“…The anticancer activity of both compounds may be generated from the protein kinases inhibition [69]. In 2021, Oanh et al reported another new xanthone derivative isolated from propolis of the stingless bee Lisotrigona furva, with weak anticancer activity against SK-LU-1, HepG2, and KB cancer cells in an IC 50 range of 12.63-34.23 µg/mL [70]. In the same year, Wang et al reported two new xanthone derivatives: oxisterigmatocystins J and K from fungus Penicillium sp.…”

Section: Isolation Of Xanthone Derivativesmentioning

confidence: 99%

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

et al. 2021

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The annual number of cancer deaths continues increasing every day; thus, it is urgent to search for and find active, selective, and efficient anticancer drugs as soon as possible. Among the available anticancer drugs, almost all of them contain heterocyclic moiety in their chemical structure. Xanthone is a heterocyclic compound with a dibenzo-γ-pyrone framework and well-known to have “privileged structures” for anticancer activities against several cancer cell lines. The wide anticancer activity of xanthones is produced by caspase activation, RNA binding, DNA cross-linking, as well as P-gp, kinase, aromatase, and topoisomerase inhibition. This anticancer activity depends on the type, number, and position of the attached functional groups in the xanthone skeleton. This review discusses the recent advances in the anticancer activity of xanthone derivatives, both from natural products isolation and synthesis methods, as the anticancer agent through in vitro, in vivo, and clinical assays.

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Section: Isolation Of Xanthone Derivativesmentioning

confidence: 99%

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

et al. 2021

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“…Cytotoxic activities of compounds 1-6 against HepG2, MCF7, and LU cancer cell lines were tested by the MTT assay. [5] Ellipticine was used as a positive control. ).…”

Section: Cytotoxic Assaymentioning

confidence: 99%

“…The isolated compounds 1-6 were evaluated for cytotoxicity against HepG-2, Lu and MCF-7 cancer cell lines using MTT method. [5] As shown in table 1, triterpenes 1 showed significant cytotoxicity against HepG-2 cancer cell line with IC50 values of 25.84±0.48 g/mL. Lantanolic acid (1), which was isolated from Lantana spp.…”

Section: Cytotoxic Assaymentioning

confidence: 99%

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Chemical constituents and cytotoxicity of Lepidotrigona ventralis propolis

Thanh,

Thu,

Oanh

et al. 2023

Vietnam Journal of Chemistry

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From propolis of Lepidotrigona ventralis stingless bee collected in Tuyen Quang province, eight compounds were isolated and determined as lantanolic acid (1), moronic acid (2), (+)‐eudesmin (3), (+)‐yangambin (4), (+)‐syringaresinol (5), (+)‐pinoresinol (6), dihydroconiferyl alcohol (7) and vanillin (8) using NMR and MS spectral data. Compounds 1 and 2 showed significant cytotoxicity against HepG‐2 cancer cell line with IC50 values of 25.84±0.48 and 39.92±1.14 μg/mL, respectively.

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“…These substances expressed comparable cytotoxicity to the positive control, doxorubicin, against these tumor cell lines, with IC 50 values from 2.84 to 15.12 µg/mL and 1.63 to 7.07 µg/mL for (4) and ( 5), respectively. Twenty-three chemical compounds were isolated from the hydroethanolic propolis extract produced by Lisotrigona furva by Oanh et al [63], among which, cochinchinone A (6), cochinchinone J (7), cratoxylumxanthone B (8), 3-isomangostin (9), and γ-mangostin (4), (Figure 2) were tested against mouth epidermoid carcinoma (KB), human hepatoma (HepG-2), human lung adenocarcinoma (SK-LU-1), and human breast adenocarcinoma (MCF-7). These compounds showed activity on the tested tumor cell lines, with compound (4) demonstrating greater activity compared to others, showing an IC 50 value of 2.10 and 2.73 µg/mL, respectively, in human hepatoma and human lung adenocarcinoma.…”

Section: Isolation Of Compoundsmentioning

confidence: 99%

Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies

et al. 2021

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Cancer is one of the major maladies affecting humankind and remains one of the leading causes of death worldwide. The investigation of the biological activities of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties, especially in the research on new antineoplastic agents. This literature review of preclinical trials, involving biological assays of antitumor activity and identification of the chemical composition of propolis and geopropolis of stingless bee species, describes the cytotoxicity in tumor lineages (breast, lung, ovarian, liver, mouth, pharynx, larynx, colon, stomach, colorectal, cervix, kidney, prostate, melanoma, human glioblastoma, canine osteosarcoma, erythroleukemia, human chronic myelocytic leukemia, and human promyelocytic leukemia) of propolis and geopropolis of 33 species of stingless bees. The chemical composition of propolis and geopropolis was identified, indicating that these belong to the chemical classes of phenolic acids, flavonoids, coumarins, benzophenones, anthraquinones, alkaloids, terpenes, steroids, saponins, fatty acids, and carbohydrates and are possibly responsible for the cytotoxicity in tumor cells. Apoptosis was one of the main mechanisms of cytotoxicity of extracts and substances isolated from stingless bee products. Although the results found are encouraging, other preclinical studies and clinical trials are essential for the discovery of new anticancer agents.

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New dihydrochromene and xanthone derivatives from Lisotrigona furva propolis

Cited by 16 publications

References 33 publications

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

Chemical constituents and cytotoxicity of Lepidotrigona ventralis propolis

Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies

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