New directions  in the diagnosis and treatment of  endometritis

Kagramanova, J.; Malinovskaya, V. V.; Выжлова, Е.Н.; Lanshchakova, P.E.

doi:10.14427/jipai.2016.1.64

Cited by 3 publications

(2 citation statements)

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“…A significant increase in the production of proinflammatory mediators TNF-α, IL-6 and IL-8, as well as C-reactive protein suggested inflammatory orientation of cell responses in women with non-developing pregnancy, which correlates with data by a number of Russian and foreign scientists [20][21][22]. Herington reports on studies that indicate a link between elevated levels of serum IL-6 and the presence of endometriosis.…”

Section: Discussionsupporting

confidence: 73%

Local Immunity Status and Apoptosis Reactions in Endometrium of Women with a History of Non-Developing Pregnancy

Gn¹,

Remizova²,

Oa³

et al. 2017

Ann Clin Lab Res

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In order to estimate the status of local immunity of women with a history of non-developing pregnancy, we conducted a research of cytokine-producing cells (CD4+IFN-γ+, CD4+IL-4+) and apoptosis markers (AnV+/ PI-, AnV+/PI+-, AnV-/PI+-cells) in endometrial biopsy material. In addition to this, we studied the number of activated blood mononuclears expressing CD95+ receptor. The research has shown that the development of chronic inflammation in endometrium is associated with anaerobic dysbiosis of vaginal microbiota coupled with impaired production of intracellular cytokines, a cytokine balance shift towards Th1-dependent immune response at the local level and an increase in production of proinflammatory mediators in blood serum. A compensatory reaction limiting the number of activated cells in endometrium is expressed in an increased number of apoptosising mononuclears at different stages of cell death. A decrease in the number of cells demonstrating readiness to programmed cell death in peripheral blood indicates that potentially dangerous activated lymphocytes are preserved in circulation at the system level. Defining the polarization index of cytokineproducing cells and the number of endometrial mononuclears expressing Fas-antigen may be used as additional criteria for early detection of endometrial conditions.

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Section: Discussionsupporting

confidence: 73%

Local Immunity Status and Apoptosis Reactions in Endometrium of Women with a History of Non-Developing Pregnancy

Gn¹,

Remizova²,

Oa³

et al. 2017

Ann Clin Lab Res

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“…Лечение, проводимое стандартно с использованием антибиотиков, не всегда эффективно, что приводит к формированию аутоиммунных механизмов поддержания патологического процесса в матке [1,3]. ХЭ может протекать бессимптомно, но при наличии клинических признаков воспалительного процесса, кроме антибиотиков, проводится комплексная терапия, включающая физиотерапию, витаминотерапию, применение нестероидных противовоспалительных препаратов, иммунную и гормональную реабилитацию [3,4,5]. В качестве одного из перспективных средств местного лечения рассматривается использование растворимых факторов тромбоцитов (РФТ), обладающих противовоспалительным и регенеративным действием, в том числе в отношении эндометрия [6,7].…”

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Modeling of bacterial lipopolysaccharide-induced endometritis in rats and the possibility of its therapy using plasma enriched with soluble platelet factors

Потапнев¹,

Pavlov²,

Доронина³

et al. 2021

Immunopathol Allergol Infectol

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We presents results of a study on endometritis modeling in rats with double intravaginal administration of bacterial lipopolysaccharide (LPS). The established endometrial inflammatory process was accompanied by a decrease in the weight of animals, an increase in the weight of the uterus, neutrophilic infiltration, edema, and overexpression of cyclooxygenase in endometrium on 30-45 days after the start of endometritis induction. Local intravaginal use of plasma enriched with soluble platelet factors/platelet-rich plasma (PORFT/PRP) caused a decrease in the intensity of the inflammatory process and the rate of neutrophil infiltration of the endometrium, a decrease in the intensity of cyclooxygenase, interleukin-6 and transforming growth factor-β expression, and an increase in the body weight of animals. The conclusion was made on the possibility of creating model of endometritis in rats by double administration of LPS and the ability of local administration of PORFT/PRP to have a therapeutic effect on the inflammatory process in the endometrium.

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Ultrasound diagnosis of endometritis: hemodynamic features of the uterus

Ozerskaya

Semiletova

Kazaryan³

2019

Medicinskaâ vizualizaciâ

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Objective.To determine the characteristics of hemodynamics of the uterus with endometritis.Material and methods.A retrospective analysis of 420 patients of reproductive age (19–53 years old) diagnosed with endometritis. The comparison group consisted of 323 women aged 17–52 without gynecological pathology.Blood flow indicators in the uterine arteries, such as maximum systolic, end-diastolic, and average blood flow velocity (Vmax, Vmin, Vmean), were estimated, and an arterial perfusion index (API) was calculated. With 3D reconstruction of the uterus in angioregime, a vascularization index (VI), a flow index (FI) and a vascular flow index (VFI) of the uterus and endometrium were obtained.Result.An increase in Vmax, Vmin, Vmean, as well as VI, VFI of the uterus and VI, FI and VFI of the endometrium in the early and middle proliferative phase of the cycle. API had monotonous values, but it should be taken into account in conjunction with VI.Conclusions.Echography combined with color mapping, spectral Doppler graphics and vascularization index determination using 3D in angio mode is a highly effective method for the diagnosis of endometritis. Characteristic changes in hemodynamics in endometritis manifest as a violation of the venous outflow in the uterus and, especially, in the endometrium, in the presence of hypervascu larization according to data VI in the aggregate of regulatory or reduced indicators of API.

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New directions in the diagnosis and treatment of endometritis

Cited by 3 publications

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Local Immunity Status and Apoptosis Reactions in Endometrium of Women with a History of Non-Developing Pregnancy

Local Immunity Status and Apoptosis Reactions in Endometrium of Women with a History of Non-Developing Pregnancy

Modeling of bacterial lipopolysaccharide-induced endometritis in rats and the possibility of its therapy using plasma enriched with soluble platelet factors

Ultrasound diagnosis of endometritis: hemodynamic features of the uterus

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