New Directions in Treatments Targeting Stroke Recovery

Lin, David J.; Finklestein, Seth P.; Cramer, Steven C.

doi:10.1161/strokeaha.118.021359

Cited by 71 publications

(54 citation statements)

References 89 publications

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“…Fluoxetine, Serotonin Selective Reuptake Inhibitor (SSRI), given for three months after the stroke, can improve patients' neurological functions [31]. This well known anti-depression drug is estimated to reduce dependency, disability and neurological impairment in post-stroke patients [32,33]. Dopamine regulates many aspects in neuronal system such as synaptic transmission and gene transcription [34].…”

Section: Small Moleculesmentioning

confidence: 99%

“…Growth factors levels increase spontaneously after the stroke. They are responsible for neuronal development, synapse formation, angiogenesis and other repair mechanisms [33]. According to the recent studies, supplementation of growth factors can prevent post-stroke cognitive impairment [36].…”

Section: Growth Factorsmentioning

confidence: 99%

“…Combined treatment with those two growth factors can significantly diminish the volume of lesions in preclinical studies [37]. Despite the fact, that there is a high probability that growth factors would have comparable effects in humans, further studies are necessary [33].…”

Section: Growth Factorsmentioning

confidence: 99%

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New directions in treatment of the ischemic stroke

Zaremba

Gorecka

Wysokińska

et al. 2020

J Educ Health Sport

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Stroke remains a leading cause of death and disability worldwide. The cause is decrease or total blocking of blood perfusion in brain and fast recognition is essential to conduct proper treatment. Currently commonly used methods are thrombolysis and mechanical thrombectomy, which high efficacy is observed only if they are performed within a few hours of the first symptoms. Hence loads of people, who are diagnosed later, become unable to undergo effective treatment. In the study are presented pathogenesis, epidemiology, classification, diagnosis and current treatment of the disease, but the main aim of the study is to present the results of the reports on new treatments for ischemic stroke. The research method is a review of the available literature published in PubMed, UpToDate and Google scholar databases. In the study were reviewed new methods, which can be alternative for currently used ones. They are small molecules including fluoxetine, aripiprazole, L-DOPA, cholinergic and 67 noradrenergic drugs, growth factors (HCG, EPO), monoclonal antibodies, allogenic stem cells, neurostimulators, robotic therapy and telerehabilitation. They give hope for curing a larger number of patients and improving effects of rehabilitation after ischemic stroke. However most of the methods, which are presented in this study require the use of tests that will allow checking their safety and application.

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Section: Small Moleculesmentioning

confidence: 99%

Section: Growth Factorsmentioning

confidence: 99%

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New directions in treatment of the ischemic stroke

Zaremba

Gorecka

Wysokińska

et al. 2020

J Educ Health Sport

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“…Nonetheless, many patients still experience severe sequelae. While many treatment methods have been developed [2], there remains no approved and effective treatment method that facilitates the recovery of patients from subacute phase post-stroke, and rehabilitation is the only method that is known to contribute to the functional recovery and increase patient quality of life (QOL) [3].…”

Section: Introductionmentioning

confidence: 99%

Regenerative Rehabilitation for Stroke Recovery by Inducing Synergistic Effects of Cell Therapy and Neurorehabilitation on Motor Function: A Narrative Review of Pre-Clinical Studies

Ito

Kubo

Liang

et al. 2020

IJMS

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Neurological diseases severely affect the quality of life of patients. Although existing treatments including rehabilitative therapy aim to facilitate the recovery of motor function, achieving complete recovery remains a challenge. In recent years, regenerative therapy has been considered as a potential candidate that could yield complete functional recovery. However, to achieve desirable results, integration of transplanted cells into neural networks and generation of appropriate microenvironments are essential. Furthermore, considering the nascent state of research in this area, we must understand certain aspects about regenerative therapy, including specific effects, nature of interaction when administered in combination with rehabilitative therapy (regenerative rehabilitation), and optimal conditions. Herein, we review the current status of research in the field of regenerative therapy, discuss the findings that could hold the key to resolving the challenges associated with regenerative rehabilitation, and outline the challenges to be addressed with future studies. The current state of research emphasizes the importance of determining the independent effect of regenerative and rehabilitative therapies before exploring their combined effects. Furthermore, the current review highlights the progression in the treatment perspective from a state of compensation of lost function to that of a possibility of complete functional recovery.

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“…They also apply to ADJUVANT treatments, defined here as those treatments (e.g., drugs, non-invasive brain stimulation) that aim to modify the effect of a primary behavioural intervention. Drugs discussed elsewhere (6)(7)(8). Each knowledge unit is necessarily considered separately but we acknowledge that they interact.…”

mentioning

confidence: 99%

A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Bernhardt

Hayward

Dancause

et al. 2019

Neurorehabil Neural Repair

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A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.

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New Directions in Treatments Targeting Stroke Recovery

Cited by 71 publications

References 89 publications

New directions in treatment of the ischemic stroke

New directions in treatment of the ischemic stroke

Regenerative Rehabilitation for Stroke Recovery by Inducing Synergistic Effects of Cell Therapy and Neurorehabilitation on Motor Function: A Narrative Review of Pre-Clinical Studies

A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

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