New Discoveries in Retinal Cell Degeneration and Retinal Diseases

Bora, Puran S.

doi:10.3390/biom13071121

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…APN1 is not an anti-VEGF treatment. Rather, it binds to Adiponectin receptor one (AdipoR1), then, through cAMP, it inhibits CNV development [86,87]. We have designed and synthesized several peptides.…”

Section: Current Understanding Of the Pathophysiological Role Of Apn/...mentioning

confidence: 99%

Linking Adiponectin and Its Receptors to Age-Related Macular Degeneration (AMD)

Choubey,

Tirumalasetty,

Bora

et al. 2023

Biomedicines

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In recent years, there has been a captivating focus of interest in elucidating the intricate crosstalk between adiponectin (APN), a versatile fat-associated adipokine and ocular pathologies. Unveiling the intricate relationship between adipocytokine APN and its receptors (AdipoRs) with aging eye disorders has emerged as a fascinating frontier in medical research. This review article delves into this connection, illuminating the hidden influence of APN on retinal health. This comprehensive review critically examines the latest findings and breakthroughs that underscore the pivotal roles of APN/AdipoRs signaling in maintaining ocular homeostasis and protecting against eye ailments. Here, we meticulously explore the intriguing mechanisms by which APN protein influences retinal function and overall visual acuity. Drawing from an extensive array of cutting-edge studies, the article highlights APN’s multifaceted functions, ranging from anti-inflammatory properties and oxidative stress reduction to angiogenic regulation within retinal and macula tissues. The involvement of APN/AdipoRs in mediating these effects opens up novel avenues for potential therapeutic interventions targeting prevalent aging eye conditions. Moreover, this review unravels the interplay between APN signaling pathways and age-related macular degeneration (AMD). The single-cell RNA-seq results validate the expression of both the receptor isoforms (AdipoR1/R2) in retinal cells. The transcriptomic analysis showed lower expression of AdipoR1/2 in dry AMD pathogenesis compared to healthy subjects. The inhibitory adiponectin peptide (APN1) demonstrated over 75% suppression of CNV, whereas the control peptide did not exert any inhibitory effect on choroidal neovascularization (CNV). The elucidation of these relationships fosters a deeper understanding of adipose tissue’s profound influence on ocular health, presenting new prospects for personalized treatments and preventative measures. Because APN1 inhibits CNV and leakage, it can be used to treat human AMD, although the possibility to treat human AMD is in the early stage and more clinical research is needed. In conclusion, this review provides a captivating journey into the enthralling world of APN, intertwining the realms of adipose biology and ophthalmology in aging.

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Section: Current Understanding Of the Pathophysiological Role Of Apn/...mentioning

confidence: 99%

Linking Adiponectin and Its Receptors to Age-Related Macular Degeneration (AMD)

Choubey,

Tirumalasetty,

Bora

et al. 2023

Biomedicines

Self Cite

View full text Add to dashboard Cite

show abstract

“…Anti-VEGF treatments can cause hemorrhage, require frequent injections to patients, and are very expensive for patients. APN1 is not an anti-VEGF treatment, it binds to Adiponectin receptor one then through CAMP it inhibits CNV development [86,87]. All modeling calculations were performed using the SYBYL program, and the structure of the peptide was built using the 'build protein' tool in SYBYL.…”

Section: Current Understanding Of the Pathophysiological Role Of Apn/...mentioning

confidence: 99%

Obesity Hormone Function in Aging Eyes: Linking Adiponectin and its Receptors to AMD

Choubey,

Tirumalasetty,

Bora

et al. 2023

Preprint

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In recent years, the interaction between adiponectin (APN), a versatile fat-associated adipokines, and eye disorders has become a captivating focus of interest. Unveiling the intricate relationship between APN and its receptors (AdipoRs) with aging eye disorders has emerged as a fascinating frontier in medical research. This review article delves into this captivating connection, illuminating the hidden influence of adipocytokine, APN on retinal health. This comprehensive review critically examines the latest findings and breakthroughs that underscore the pivotal roles of APN/AdipoRs signaling in maintaining ocular homeostasis and protecting against eye ailments. Here, we meticulously explore the intriguing mechanisms by which APN protein influences retinal function, lens clarity, and overall visual acuity. Drawing from an extensive array of cutting-edge studies, the article highlights APN's multifaceted functions, ranging from anti-inflammatory properties and oxidative stress reduction to angiogenic regulation within retinal and macula tissues. The involvement of APN/AdipoRs in mediating these effects opens up novel avenues for potential therapeutic interventions targeting prevalent aging eye conditions. Moreover, this review unravels the interplay between APN signaling pathways and age-related macular degeneration (AMD). The single-cell RNA seq results validate the expression of both the receptor isoform (AdipoR1/R2) in retinal cells. The transcriptomic analysis showed lower expression of AdipoR1/2 in dry AMD pathogenesis compared to healthy subjects. The inhibitory peptide (APN1) demonstrated over 75% suppression of CNV, whereas the control peptide did not exert any inhibitory effect on CNV. The elucidation of these relationships fosters a deeper under-standing of adipose tissue's profound influence on ocular health, presenting new prospects for personalized treatments and preventative measures. In conclusion, "Obesity Hormone's Role in Aging Eyes: Linking Adiponectin/AdipoRs to AMD" provides a captivating journey into the enthralling world of APN intertwining the realms of adipose biology and aged ophthalmology.

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New Discoveries in Retinal Cell Degeneration and Retinal Diseases

Abstract: Age-related macular degeneration (AMD) has two phenotypes: dry AMD and wet AMD [...]

Cited by 2 publications

References 18 publications

Linking Adiponectin and Its Receptors to Age-Related Macular Degeneration (AMD)

Linking Adiponectin and Its Receptors to Age-Related Macular Degeneration (AMD)

Obesity Hormone Function in Aging Eyes: Linking Adiponectin and its Receptors to AMD

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