New doxorubicin nanocarriers based on cyclodextrins

Abstract

Polymeric nanoparticles and fibrin gels (FBGs) are attractive biomaterials for local delivery of a variety of biotherapeutic agents, from drugs to proteins. We combined these different drug delivery approaches by preparing nanoparticle-loaded FBGs characterized by their intrinsic features of drug delivery rate and antiproliferative/apoptotic activities. Inclusion complexes of doxorubicin (DOXO) with oligomeric β-cyclodextrins (oCyD) functionalized with different functional groups were studied. These nanocarriers were able to interact with FBGs as shown by a decreased release rate of DOXO. One of these complexes, oCyDNH/DOXO, demonstrated good antiproliferative and apoptotic activity in vitro, reflecting a higher drug uptake by cells. As hypothesized, the nanocarrier/FBG complexes showed a lower drug release rate than similar FBGs loaded with the corresponding non-functionalized oCyD/DOXO. Taken together, our results provide experimental evidence that oCyDNH/DOXO complexes may be useful components in enhanced FBGs and further build support for the great promise these complex molecules hold for clinical use in localized anticancer therapy of inoperable or surgically removable tumors of different histological origin.

Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting

“…The reduction of DOXO toxic (vesicant and necrotizing) effects of different nanotechnological platforms compared to the free drug has been reported . In light of the interest for DOXO carriers based on CyD derivatives, we investigated the cytotoxicity of DOXO in the presence of the new polymers.…”

Cyclodextrin‐Based Nanosponges for Improving Solubility and Sustainable Release of Curcumin

“…According to the type of CD, the crosslinker and the processing condition, CDNSs with various cavity sizes and polarity and crystallinity can be obtained. CDNSs, based‐on their nature, have been used in different kinds of applications such as drug and oxygen delivery systems, agriculture, cosmetic, catalyst support, water purification, and responsive hydrogels . Biodegradability, biocompatibility, stability in the pH of 1–11 and negligible toxicity of NSs rendered them as safe drug carriers .…”

A NIR-responsive indocyanine green-genistein nanoformulation to control the polycomb epigenetic machinery for the efficient combinatorial photo/chemotherapy of glioblastoma

“…23 Recently, protein nanoparticles used as drug delivery vehicles and multimodal combinatorial approaches for photodynamic therapy (PDT) and photothermal therapy (PTT) have generated considerable interest. [23][24][25][26] PDT is a wellestablished clinical treatment modality that involves light and chemical photosensitizers along with oxygen in the tissues for the successful treatment of various cancers and non-malignant diseases. 27 An antitumor PDT using indocyanine green (ICG) has been reported previously.…”