New Drug Metabolism Inhibitor of Marine Origin

Kaul, Pushkar N.; Kulkarni, Shrinivas K.

doi:10.1002/jps.2600670927

Cited by 47 publications

(24 citation statements)

References 4 publications

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“…An increase in the sleeping time is classically related to CNSdepressant drugs (Willianson et al, 1996). Earlier studies have related the prolongation of barbital hypnosis to pentobarbital metabolic inhibition or action on the CNS involved in the regulation of sleep (Kaul and Kulkarni, 1978). Ours fi ndings showed that terpinen-4-ol (100 and 200 mg/kg) produced a signifi cant dose-dependent increase in the duration of sleep (Fig.…”

Section: Resultsmentioning

confidence: 57%

Evaluation of the Anticonvulsant Activity of Terpinen-4-ol

Sousa

Nóbrega

Morais

et al. 2009

Zeitschrift Für Naturforschung C

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Terpinen-4-ol is a monoterpenoid alcohol and component of the essential oils of several aromatic plants. Similarly to terpinen-4-ol, other monoterpenoid alcohols have shown anticonvulsant activity in convulsion animal models. The present study aimed to investigate the anticonvulsant activity of terpinen-4-ol. Treatment of mice with terpinen-4-ol ( 200 mg/kg) caused a signifi cant decrease in the spontaneous motor activity at 30, 60 and 120 min after administration. Terpinen-4-ol (100 and 200 mg/kg) produced a significant dosedependent increase in the duration of sleeping in mice. Pretreatment of mice with terpinen-4- ol at doses of 100, 200 and 300 mg/kg significantly increased the latency of pentylenetetrazole -induced convulsions. Terpinen-4-ol (200 and 300 mg/kg) also inhibited the induced seizures of picrotoxin. In another model, maximal electroshock seizure, terpinen-4-ol decreased the tonic hind convulsions percentage at the dose of 300 mg/kg. From the overall results we can conclude that terpinen-4-ol showed a depressant effect on the central nervous system and significant anticonvulsant activity.

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Section: Resultsmentioning

confidence: 57%

Evaluation of the Anticonvulsant Activity of Terpinen-4-ol

Sousa

Nóbrega

Morais

et al. 2009

Zeitschrift Für Naturforschung C

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“…The experimental data presented in Table 4 shows that the extract of C. viscosum significantly increased the duration of the pentobarbital sleeping time. Prolongation of pentobarbital hypnosis is believed to be a sedative and=or hypnotic property (Fujimori, 1965) and could be attributed to inhibition of pentobarbital metabolism (Kaul & Kulkarni, 1978) or a central mechanism involved in the regulation of sleep (N'Gouemo et al, Table 3. Effect of methanol extract of C. viscosum on acetic acid-induced writhing in mice.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory, Antinociceptive, and Neuropharmacological Activities ofClerodendron viscosum.

Ahmed

Shahid

Biswas

et al. 2007

Pharmaceutical Biology

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The crude methanol extract of Clerodendron viscosum Vent. (Verbenaceae) leaves was evaluated for its antiinflammatory, antinociceptive, and neuropharmacological activities. When given orally to rats at doses of 200 and 400 mg=kg of body weight, the extract showed a significant (p < 0.001) anti-inflammatory activity against carrageenan-induced rat paw edema comparable with the standard drug phenylbutazone at the dose of 100 mg=kg of body weight. It also produced a significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg=kg of body weight (p < 0.001), which was comparable with the standard drug diclofenac sodium at the dose of 25 mg=kg of body weight. Moreover, when given intraperitoneally to albino mice, it potentiated the pentobarbital-induced sleeping time (p < 0.001), decreased the open field score in open field test (p < 0.001), decreased the number of holes crossed from one chamber to the other in the hole-cross test (p < 0.001), and decreased the head dip responses in the hole-board test (p < 0.001) at the dose of 250 and 500 mg=kg of body weight. The overall results tend to suggest the anti-inflammatory, antinociceptive, and central nervous system depressant activities of the crude methanol extract of Clerodendron viscosum.

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“…The extract potentiates Pentobarbitone induced sleeping time that may be attributed to an action on the central mechanism involved in the regulation of sleep 12,13 . The prolongation of Pentobarbital-induced sleeping time may be attributed to an inhibition of Pentobarbital metabolism 14 . The extract prolongation of Pentobarbital sleep suggests that barbitalinduced hypnosis is a good index of CNS depressant activity 15 .…”

Section: Discussionmentioning

confidence: 98%

“…GABA A is the major inhibitory neurotransmitter in the CNS. Different anxiolytic, muscle relaxant, sedative-hypnotic drugs elicit their action through GABA A , therefore it is possible that extracts of Cynometra ramiflora may act by potentiating GABAergic inhibition in the CNS via membrane hyperpolarization which leads to a decrease in the firing rate of critical neurons in the brain or may be due to direct activation of GABA receptor by the extracts 18 . Antibacterial activity was tested by using the disc diffusion method.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Neuropharmacological, Antibacterial and Antinociceptive Activity of Methanolic Extract of the Bark of Cynometra Ramiflora Linn. (Leguminosae)

Afjalus¹,

Salahuddin²,

Emrul³

et al. 2013

Int. J. Res. Ayurveda Pharm.

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The crude methanolic extract of the bark of Cynometra ramiflora Linn. (Leguminosae) growing in southeast part of Bangladesh has been evaluated for its possible neuropharmacological, antibacterial and antinociceptive properties. The extract of Cynometra ramiflora bark potentiated the pentobarbital induced sleeping time in mice, decreased the open field score in open field test, decreased the number of hole crossed from one chamber in the hole cross test and decreased the head dip responses in hole board test. Acute toxicity test showed that the plant might be safe for pharmacological uses. Antibacterial activity of Cynometra ramiflora bark was tested by disk diffusion method. The extract exhibited significant antibacterial activity against Vibrio cholerae, Salmonella typhi, Staphylococcus aureus and exhibited moderate antibacterial activity against Escherichia coli, Shigella dysenteriae, Shigella sonnei, Enterococci, Shigella boydii, Shigella flexneri, Staphylococcus epidermis. The methanolic extract exhibited statistically significant writhing inhibition in acetic acid-induced writhing model in white albino mice. The crude extract produced 48.62% inhibition of writhing at the dose of 250 mg/kg body weight and 63.89% inhibition of writhing at the dose of 500 mg/kg body weight, while the standard drug Diclofenac-Na inhibition was found to produce 69.45% at a dose of 25 mg/kg body weight.

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New Drug Metabolism Inhibitor of Marine Origin

Cited by 47 publications

References 4 publications

Evaluation of the Anticonvulsant Activity of Terpinen-4-ol

Evaluation of the Anticonvulsant Activity of Terpinen-4-ol

Anti-inflammatory, Antinociceptive, and Neuropharmacological Activities ofClerodendron viscosum.

Evaluation of Neuropharmacological, Antibacterial and Antinociceptive Activity of Methanolic Extract of the Bark of Cynometra Ramiflora Linn. (Leguminosae)

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