Anti-inflammatory, Antinociceptive, and Neuropharmacological Activities ofClerodendron viscosum.

Abstract

The crude methanol extract of Clerodendron viscosum Vent. (Verbenaceae) leaves was evaluated for its antiinflammatory, antinociceptive, and neuropharmacological activities. When given orally to rats at doses of 200 and 400 mg=kg of body weight, the extract showed a significant (p < 0.001) anti-inflammatory activity against carrageenan-induced rat paw edema comparable with the standard drug phenylbutazone at the dose of 100 mg=kg of body weight. It also produced a significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg=kg of body weight (p < 0.001), which was comparable with the standard drug diclofenac sodium at the dose of 25 mg=kg of body weight. Moreover, when given intraperitoneally to albino mice, it potentiated the pentobarbital-induced sleeping time (p < 0.001), decreased the open field score in open field test (p < 0.001), decreased the number of holes crossed from one chamber to the other in the hole-cross test (p < 0.001), and decreased the head dip responses in the hole-board test (p < 0.001) at the dose of 250 and 500 mg=kg of body weight. The overall results tend to suggest the anti-inflammatory, antinociceptive, and central nervous system depressant activities of the crude methanol extract of Clerodendron viscosum.

Antinociceptive effect of methanol extract ofCapparis ovatain mice

“…In addition, writhing response is widely accepted as a model visceral pain due to the release of endogen mediators of pain, such as prostaglandins, kinins, etc. (Derardt et al, 1980;Ahmed et al, 2007;Sulaiman et al, 2008;Zheng et al, 2009). Based on findings obtained in the present study, it was concluded that CME possesses a significant antinociceptive activity both at spinal and supraspinal levels.…”

“…CME was tested for the presence of alkaloids, tannins, reducing sugar, and flavonoids by using standard phytochemical procedures. In each test we used 10% (w/v) methanol solution of extract (Trease & Evans, 2002;Ahmed et al, 2007).…”

Antinociceptive activity of methanol extract of fruits of Capparis ovata in mice

“…In each test, we used 10% (w/v) methanol solution of extract was used (Evans, 2002;Ahmed et al, 2007). The total phenolic content of extracts was determined using to the Folin-Ciocalteu method (Akkol et al, 2008).…”

Preclinical evaluation of antihyperglycemic activity of Clerodendron infortunatum leaf against streptozotocin-induced diabetic rats

“…Previous phytochemical investigation of the plant revealed the presence of alkyl sterols and 2,-(3,4-dehydroxyphenyl) ethanol 1-O-α-2 rhamnopyranosyl-(1→3)-β-D-(4-O-caffeoyl) glycopyranoside or acteoside 6,7. Previous work has reported hepatoprotective, anti-inflammatory, antinociceptive, and neuropharmacological activities of C. infortunatum 8–10. Until now, there have been no reports on antidiabetic investigations of this plant.…”