New Drugs - From Necessity to Delivery

Kędzierska, Ewa; Dąbkowska, Lila; Krzanowski, Tomasz; Gibuła, Ewa; Orzelska‐Górka, Jolanta; Wujec, Monika

doi:10.1515/cipms-2018-0020

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…These make it possible to determine the toxicity, teratogenicity, likely effects on the embryo, fetus, and offspring in subsequent generations. Therefore, although there is a legitimate need to replace laboratory animals in research, a universal solution has still not been developed that offers this possibility for every type of experiment [ 148 , 149 ].…”

Section: Pre-clinical In Vitro and In Vivo Studiesmentioning

confidence: 99%

Research in the Field of Drug Design and Development

Biala,

Kedzierska,

Kruk-Slomka

et al. 2023

Pharmaceuticals

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The processes used by academic and industrial scientists to discover new drugs have recently experienced a true renaissance, with many new and exciting techniques being developed over the past 5–10 years alone. Drug design and discovery, and the search for new safe and well-tolerated compounds, as well as the ineffectiveness of existing therapies, and society’s insufficient knowledge concerning the prophylactics and pharmacotherapy of the most common diseases today, comprise a serious challenge. This can influence not only the quality of human life, but also the health of whole societies, which became evident during the COVID-19 pandemic. In general, the process of drug development consists of three main stages: drug discovery, preclinical development using cell-based and animal models/tests, clinical trials on humans and, finally, forward moving toward the step of obtaining regulatory approval, in order to market the potential drug. In this review, we will attempt to outline the first three most important consecutive phases in drug design and development, based on the experience of three cooperating and complementary academic centers of the Visegrád group; i.e., Medical University of Lublin, Poland, Masaryk University of Brno, Czech Republic, and Comenius University Bratislava, Slovak Republic.

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Section: Pre-clinical In Vitro and In Vivo Studiesmentioning

confidence: 99%

Research in the Field of Drug Design and Development

Biala,

Kedzierska,

Kruk-Slomka

et al. 2023

Pharmaceuticals

Self Cite

View full text Add to dashboard Cite

show abstract

“…Over the last decades, we have seen a decrease in the number of new medicines introduced to the market. This is primarily due to the high costs of research and the length of the various stages of new substance testing [1]. Only 48 drugs have been approved for use by the Food and Drug Administration (FDA) in 2019 [2] and another 53 in 2020 [3].…”

Section: Introductionmentioning

confidence: 99%

Detailed Comparison between the Safety Profiles of Chloroquine and Hydroxychloroquine

Kowalska

Fijałkowski

Nowaczyk

2021

The 1st International Electronic Conference on Biomedicine

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Introducing an innovative drug to the market requires not only large amounts of money, but also time. Therefore, the process of repositioning, i.e., finding new indications for drugs already in use, is becoming more and more frequent. In 2020, chloroquine (CQ) and hydroxychloroquine (HCQ) were approved for the treatment of severe COVID-19 infection. However, studies have shown that the adverse effects of these drugs are too serious and the approval was revoked. The most serious and most frequently reported adverse effects were cardiotoxicity and neurotoxicity. For this reason, the study investigates the possible mechanism of cardiotoxicity and neurotoxicity of CQ and HCQ using in silico computational methods. The results of this study were found to be consistent with the literature.

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New Drugs - From Necessity to Delivery

Cited by 2 publications

References 24 publications

Research in the Field of Drug Design and Development

Research in the Field of Drug Design and Development

Detailed Comparison between the Safety Profiles of Chloroquine and Hydroxychloroquine

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