New experimental corrosive esophagitis model in rats

Şentürk, Ekrem; Sen, Sayan; Pabuccu, Engin; Ünsal, Cengiz; Meteoğlu, İbrahim

doi:10.1007/s00383-009-2546-0

Cited by 15 publications

(22 citation statements)

References 11 publications

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“…Measurement of the esophagus volume and constitution of corrosive esophagitis is controversial matter a lot of manuscripts. But it is not problem on our noninvasive model [16]. At the end of the first [ ( ) T D $ F I G ] Fig.…”

Section: Discussionmentioning

confidence: 98%

“…The study was performed on a minimal invasive model which did not require general anesthesia and abdominal operation [16]. The experiment was done under ether anesthesia and standard animal care with analgesia was provided.…”

Section: Experimental Modelmentioning

confidence: 99%

“…It is stated that in a minimally invasive corrosive esophagitis model a burn can be achieved throughout the esophagus by 40% NaOH and this model is suitable also for the treatment [16]. With this aim, we compared in our study in a minimally invasive model [16], the effect of mitomycin-c and heparin which have different mechanisms of action on corrosive esophagitis cases caused by 40% NaOH.…”

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confidence: 92%

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Comparison of mitomycin-c and heparin affects in experimental corrosive esophagitis on rats

Şentürk¹,

Pabuşçu²,

Sen³

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 98%

Section: Experimental Modelmentioning

confidence: 99%

mentioning

confidence: 92%

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Comparison of mitomycin-c and heparin affects in experimental corrosive esophagitis on rats

Şentürk¹,

Pabuşçu²,

Sen³

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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“…In each specimen, five microscopy fields were evaluated and graded by a histologist blinded to the study groups. The burn injury was graded as normal, 0; grade 1 only the epithelial injury, grade 2 injury involving epithelium and muscularis mucosa, grade 3 injury proceeding to submucosa, grade 4 injury proceeding to inner circular muscle layer, and grade 5 full-thickness injury development [10,11].…”

Section: Histopathologic Examination Of the Esophagusmentioning

confidence: 99%

The diagnostic utility of scintigraphy in esophageal burn: a rat model

Çiftçi

Gül

Açıksarı

et al. 2016

Journal of Surgical Research

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“…Before creating the esophagus burn in esophagitis, models by Erturk et al [7]. used an endoscope to measure the esophagus length of the rats and to create the burn using a Fogarty catheter within a guide.…”

Section: Discussionmentioning

confidence: 99%

Experimental Esophagitis Model Preventing Tracheal Aspiration

Kiraz¹,

Erbaş²,

Küçük³

et al. 2015

Adv Clin Exp Med

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Background. Corrosive esophagitis injuries are a serious clinical problem with many agents used for diagnosis and treatment. Experimental esophagus burn models use a method described mainly in studies by Gehanno and Guedon, and modified by Liu and Richardson. Objectives. The aim of this study was to describe a new esophagitis model that prevents tracheal aspiration. Material and Methods. In this study we used 16 Wistar albino rats weighing between 220-240 g. The experimental animals were randomly divided into two groups: the model group (group M, n: 8) and control group (group C, n: 8). The necessary anesthesia was administered. Passing through a median laparotomy incision, the abdomen was entered and in group M and C the esophagus was freed and held by a suture at the gastroesophageal junction. After this procedure, about 1 cm proximal to the gastroesophageal junction, the esophagus was suspended by a suture. The esophagus segment between the two sutures was exposed to 0.1 mL 10% NaOH in group M and 0.1 mL saline in group C for 20 s. Ten days later all experimental animals were sacrificed and their esophagus removed. After dying with hematoxylin and eosine trichrome, the histopathological evaluation results for the rats in all groups were investigated with a light microscope. Results. Histopathological examination indicated submucosal collagen increase, damage to muscularis mucosa and tunica muscularis and collagen deposition. In the model group, the rats had high neutrophils and tissue damage accompanied by necrosis. In the control group, the rats had minimal or no tissue damage and fibrosis was not observed. Conclusions. Our procedure is relatively less invasive and easy to apply with corrosive esophagitis only in the required region, and at the same time treatment medications can be easily administered (Adv Clin Exp Med 2015, 24, 4, 637-641).

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New experimental corrosive esophagitis model in rats

Cited by 15 publications

References 11 publications

Comparison of mitomycin-c and heparin affects in experimental corrosive esophagitis on rats

Comparison of mitomycin-c and heparin affects in experimental corrosive esophagitis on rats

The diagnostic utility of scintigraphy in esophageal burn: a rat model

Experimental Esophagitis Model Preventing Tracheal Aspiration

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