The axial compression ratio has a significant effect on the strength and ductility of reinforced concrete (RC) columns subjected to seismic loads. However, limited numerical models have been found to be able to consider the effect of axial compression ratio in mesoscopic scale. To achieve a sound understanding of the hysteretic mechanism of RC columns with different axial compression ratios, a novel modelling method was developed by employing the following techniques: (a) the extended finite element method for modelling crack initiating and propagating in concrete; (b) the contact algorithm for modelling the crack closure; and (c) the Cartesian type "connector" for modelling the interaction between concrete and steel bars. The effectiveness of the proposed model was validated in macroscopic scale by the results of a previous experimental study. Further analysis indicates that the axial compression ratio controls the axial deformations of RC columns, thus leads to different performances of concrete and steel under seismic loads. Based on the individual flexural contributions of the concrete and the steel bars, the effect of the axial compression ratio and the pinching effect is explained in a finer scale. The analytical results shed some light on the seismic mechanism of RC columns with different axial compression ratios. KEYWORDS axial compression ratio, extended finite element method, hysteretic loop, reinforced concrete column, seismicity XFEM to model the effect of different axial compression on the hysteretic behaviour of the flexure-dominant RC columns. Struct Design Tall Spec Build. 2018;27:e1465. https://doi.