Systems based on quantum-dot nanostructures could be used as components for quantum information processing devices. One of the possible advantages of the use of quantum dots is that the parameters of the system may be changed, allowing the properties of semiconductor nanostructures to be tailored. The seemingly inexorable progress of technology appears to promise advanced engineering of quantum dot based structures, thus leading to the fabrication of coupled and scalable quantum dot systems. To use quantum dot devices for quantum computing necessitates the ability to generate and manipulate entanglement within these structures. Using Supersymmetric Quantum mechanics, isospectral Hamiltonian approach is utilized to calculate the information entropy of the isospectral potential which contains a free parameter. This free parameter can be adjusted to model the complex nanostructure materials and therefore to calculate their entanglement degree.