1999
DOI: 10.1016/s0304-8853(98)00568-x
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New ferro-carbon adsorbents for magnetically guided transport of anti-cancer drugs

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Cited by 96 publications
(64 citation statements)
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“…Finally, it should be mentioned that the cytotoxicity of this material is expected to be similar to the commercial iron oxide products, because its composition is chemically equivalent to the commercial products, which are considered as non toxic [45]. Moreover, the presence of small amounts of carbon was previously considered of low toxicity [46].…”
Section: Blood Clearance and Mri Studiesmentioning
confidence: 98%
“…Finally, it should be mentioned that the cytotoxicity of this material is expected to be similar to the commercial iron oxide products, because its composition is chemically equivalent to the commercial products, which are considered as non toxic [45]. Moreover, the presence of small amounts of carbon was previously considered of low toxicity [46].…”
Section: Blood Clearance and Mri Studiesmentioning
confidence: 98%
“…Magnetic targeting of drugs decreases the quantities of an active agent by several orders of magnitude and increases its concentration at the tumor site by dozens of times. It involves magnetic targeted carriers, most commonly, suspensions of ultradispersed magnetic iron-and carbon-containing particles (sorbents) the surface of which is modified and loaded with an active agent (various compounds) as proposed previously (Kuznetsov et al , 1997(Kuznetsov et al , , 1999. A drug is associated with magnetic particles due to the absorption on carbon.…”
Section: Introductionmentioning
confidence: 97%
“…15 Briefly, a streptomycin solution (0.58 g) was added dropwise while stirring into an aqueous dispersion of MNP. The mixture of CS-MNP in the streptomycin solution was magnetically stirred at room temperature for 18 hours to facilitate streptomycin uptake.…”
Section: Preparation Of Strep-cs-mnpmentioning
confidence: 99%