New fluorescent isoquinoline derivatives

Balog, J.; Riedl, Zsuzsanna; Hajós, György; Miskolczy, Zsombor; Biczók, László

doi:10.1016/j.tetlet.2011.07.143

Cited by 8 publications

(8 citation statements)

References 7 publications

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“…Isoquinoline derivatives make part of large family of natural products with a wide range of biological activity such as antitumor, antibacterial, and antibiotic properties . Additional applications such as fluorosensors, or dye sensitized solar cells are also known . On the other hand, phthalazines have shown a great potential as DNA intercalators, making PTDI molecules interesting scaffolds to be studied in biomedical applications, which is supported by the fact that properly functionalized NDIs have shown to bind effectively to viral G‐quadruplexes (G4s), producing not only efficient fluorescent probes of G4, but also showing a remarkable anti‐HIV activity .…”

Section: Methodsmentioning

confidence: 99%

A Family of Heterocyclic Naphthalene Diimide (NDI) Analogues: Comparing Parent Isoquinoline Diimides and Phthalazine Diimides with NDI

et al. 2019

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Parent isoquinoline diimide (IQDI) and phthalazine diimide (PTDI), as two new heterocyclic analogues of naphthalene diimides (NDIs), have been synthesized through an oxidative strategy in 35–79 % yield. X‐ray crystallography has been used to support the formation of IQDI, which also show fluorescence quantum yields of 3.5 %. The electrochemical and electrical properties of these molecules have been studied. The electrochemical results show an interesting trend in first reduction potential PTDI

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Section: Methodsmentioning

confidence: 99%

A Family of Heterocyclic Naphthalene Diimide (NDI) Analogues: Comparing Parent Isoquinoline Diimides and Phthalazine Diimides with NDI

et al. 2019

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“…nd - not determined. ** 3-aminoisoquinoline (isoquinolin-3-amine) dissolved in acetonitrile [14]. *** quinine sulfate in 0.1 M H 2 SO 4 (used as a standard).…”

Section: Figures Schemes and Tablementioning

confidence: 99%

“…An inspection of the literature data indicates that isoquinoline-3-amine derivatives exhibit fluorescent properties and may constitute potential fluorophores [13,14,15]. Moreover, for many years the electronic states and optical properties of isoquinoline and its derivatives have been an object of particular interest and study [16,17,18,19,20,21,22,23,24,25].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Fluorescent Properties of Novel Isoquinoline Derivatives

et al. 2019

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Isoquinoline derivatives have attracted great interest for their wide biological and fluorescent properties. In the current study, we focused on the synthesis of a series of novel isoquinoline derivatives substituted at position 3 of the heteroaromatic ring. Compounds were obtained in a Goldberg–Ullmann-type coupling reaction with appropriate amides in the presence of copper(I) iodide, N,N-dimethylethylenediamine (DMEDA), and potassium carbonate. The structures of novel isoquinolines were confirmed by IR, NMR, and elemental analysis, as well as X-ray crystallography. In the course of our research work, the visible fluorescence of this class of compounds was observed. The above findings prompted us to investigate the optical properties of the selected compounds.

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“…Polymers, solutions of surfactants, solid surfaces, biological membranes, proteins, nucleic acids and living cells are well-known examples of systems in which estimates of local parameters such as polarity, fluidity, order, molecular mobility and electrical potential is possible by means of fluorescent molecules playing the role of probes. [4][5][6][7] The latter can be intrinsic or introduced on purpose. The high sensitivity of fluorimetric methods in conjunction with the specificity of the response of probes to their microenvironment contribute towards the success of this approach.…”

Section: Introductionmentioning

confidence: 99%