New frontiers and developing applications in 19F NMR

Quantitative NMR Studies of Multiple Compound Mixtures

“…Quantitative 1D 19 F NMR is widely applied in pharmaceutical, polymer, and organic industries [51][52][53]. Fluorine ( 19 F) nucleus is similar to hydrogen ( 1 H) with nuclear spin I ¼ 1/2, a large gyromagnetic ratio of 40.05 MHz/T, and natural abundance of 100% [54], which opens a way to selective, sensitive, and quantitative detection of fluorinated compounds in complex matrices.…”

Commentary on Photoacoustic Tomography

“…Use of heteronuclei, which occur at naturally low concentrations, avoids background signal, allowing massive isotope enrichment and signal amplification (e.g., 13 C), which may be enhanced further using dynamic hyperpolarization (2). Exogenous 19 F also provides versatile agents with exquisite sensitivity to the microenvironment and a large chemical shift range so that multiple reporters may be assessed simultaneously (3). CT is essentially an anatomic imaging approach, with limited contrast agents, although multispectral CT is emerging.…”

19F-Modified Proteins and 19F-Containing Ligands as Tools in Solution NMR Studies of Protein Interactions

“…Many protein-binding molecules have been modified with 19 F atoms, including nucleic acids, peptides, carbohydrates, and a myriad of small molecules (Chen, Viel, Ziarelli, & Peng, 2013;Fielding, 2007;Ghitti, Musco, & Spitaleri, 2014;Kiviniemi & Virta, 2010;Matei et al, 2013;Tanabe, Sugiura, & Nishimoto, 2010;Yu, Hallac, Chiguru, & Mason, 2013). Among these, incorporation of 19 F atoms into small molecule drugs is of particular interest, since the presence of 19 F atoms in small molecules has been shown to improve their pharmacokinetic and physicochemical properties.…”