New guidelines for diagnosis and treatment of coeliac disease in children and adolescents

Iwańczak, F; Iwańczak, Barbara

doi:10.5114/pg.2012.30500

Cited by 10 publications

(6 citation statements)

References 12 publications

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“…There are four different clinical forms of CD: classical, silent, latent, and potential (genetic susceptibility for CD) [12]. …”

Section: Introductionmentioning

confidence: 99%

The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes

Domżał-Magrowska¹,

Kowalski²,

Szcześniak³

et al. 2016

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IntroductionIrritable bowel syndrome (IBS) and celiac disease (CD) share some gastrointestinal symptoms. Celiac disease should be considered in a differential diagnosis of IBS.AimTo estimate the prevalence of predispositions to CD in patients with IBS and its subtypes.Material and methodsThe study included 48 patients (40 women, 8 men; average age: 41.1 ±14.6 years) with IBS, and a control group: 20 healthy volunteers. All participants completed a questionnaire on their current gastrointestinal symptoms and had a blood sample taken to determine the HLA-DQ2/DQ8 antigens and serum concentration of anti-tTG IgA and anti-DGP IgA and IgG.ResultsThe presence of HLA-DQ2 or DQ8 was found in 50% of patients (n = 24) with IBS. In the control group the presence of HLA-DQ2 was found in 4 (20%) patients and nobody had HLA-DQ8. Increased levels of anti-tTG IgA were found in 5 (10.42%) patients with IBS, anti-DGP in 4 (8.33%), and anti-DGP IgG in 3 (6.25%). In the control group positive test result for anti-tTG was found in 2 (10%) patients; nobody had elevated anti-DGP IgA or IgG. A concomitant positive result of genetic testing and any elevated serum antibodies specific to CD was found in 12.5% of IBS patients (n = 6) and in none of the control group.ConclusionsPatients with IBS, regardless of the subtype, significantly more often than healthy controls have the predisposing genetic factors (HLA-DQ2/DQ8) underlying the development of CD.

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“…There are four different clinical forms of CD: classical, silent, latent, and potential (genetic susceptibility for CD) [12]. …”

Section: Introductionmentioning

confidence: 99%

The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes

Domżał-Magrowska¹,

Kowalski²,

Szcześniak³

et al. 2016

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“…In IgAD, antibodies for celiac disease were noted in 20% of the patients, which supported observations of increased risk of this disease in IgAD. Moreover, due to the possibility of ongoing celiac disease in latent, asymptomatic form, clinical and laboratory diagnostic procedures are indicated as the subsequent steps without any undue time loss [ 19 , 23 ]. All these patients were without typical clinical symptoms suggestive of a particular inflammatory disease.…”

Section: Discussionmentioning

confidence: 99%

“…In children without immune deficiency, the immunological detection of celiac disease based on autoantibodies and IgA class antibodies in the serum is clinically valuable as a screening test. In CVID and IgAD patients, the results of tests based on IgA may be false negative and the results of tests based on IgG should be considered as valuable and clinically significant [ 2 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Occurrence of autoantibodies for gastrointestinal autoimmune diseases in children with common variable immune deficiency and selected IgA deficiency

Pituch‐Noworolska¹,

Błaut-Szlósarczyk²,

Zwonarz³

2013

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IntroductionSelected IgA deficiency (IgAD) and common variable immune deficiency (CVID) are humoral immunity deficiencies frequent in children. In both these types of immunodeficiency, autoimmune diseases are present in 20–30% of patients, but the disease profiles are different between adults and children. Autoimmune diseases of the gastrointestinal tract (IBD) and celiac disease are typical for children with IgAD and CVID. Diagnosis is based on clinical symptoms, histology of jejunum and antibodies often preceding the onset of disease. However, the diagnosis of IBD and celiac disease is difficult in immune deficiency patients due to weaker or absent production of antibodies, and different jejunum histology, particular in CVID patients.AimDetection of antibodies for autoimmune diseases in children with diagnosis of CVID and IgAD.Material and methodsThe study included 43 children with CVID and 63 children with IgAD diagnosis. Antibodies typical for celiac disease (for endomysium, tissue transglutaminase and gliadin) were tested in IgA class (CVID patients), IgG class (IgAD, CVID patients) and found in 16 patients (3 – CVID, 13 – IgAD).ResultsAntibodies for IBD (for Saccharomyces cerevisiae antigen – ASCA, goblet cells – Gab, neutrophil’s cytoplasm – ANCA, pancreatic cells – Pab) were noted in 17 patients (7 – CVID, 10 – IgAD). Celiac disease was diagnosed in two children with mild and unspecific clinical symptoms followed by introduction of a gluten-free diet. The remaining children with present antibodies but without clinical symptoms involving the gastrointestinal tract are under careful clinical observation with antibody assay every 6 months.ConclusionsThe antibodies are produced despite impaired humoral immunity but the level might be low so the lower limit of positive results is postulated.

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“…It is characterised by diverse clinical manifestations, the presence of specific antibodies in serum, the HLA-DQ2 and/or HLA-DQ8 haplotype, and enteropathy. The factor causing the disease is gluten – a plant protein found in wheat, rye, and barley [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Non-dietary methods in the treatment of celiac disease

Szaflarska-Popławska

2015

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This is a selective review of the literature concerning the methods of celiac disease treatment, which can be an alternative to a gluten-free diet. The most advanced studies are devoted to the larazotide acetate (AT-1001, human zonulin inhibitor) and prolyl-endopeptidases degrading toxic gluten peptides (ALV003, AN-PEP). It is estimated that they will be registered within a few years. They will not become an alternative to the gluten-free diet but rather a supplement to it, which will enable patients to ease the nutritional restrictions.

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New guidelines for diagnosis and treatment of coeliac disease in children and adolescents

Cited by 10 publications

References 12 publications

The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes

The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes

Occurrence of autoantibodies for gastrointestinal autoimmune diseases in children with common variable immune deficiency and selected IgA deficiency

Non-dietary methods in the treatment of celiac disease

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