New hepatitis viruses: Contenders and pretenders

Bowden, Scott

doi:10.1046/j.1440-1746.2001.02405.x

Cited by 36 publications

(20 citation statements)

References 74 publications

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“…SENV was speculated to be a new virus that might cause cryptogenic chronic hepatitis. SENV-D and SENV-H were reported to be associated with transfusion-associated hepatitis [Primi and Sottini, 2000;Umemura et al, 2001;Bowden, 2001;Tanaka et al, 2001]. In this study, a retrospective analysis of viral hepatitis was undertaken in which no serological markers of hepatotropic virus infection were detected.…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of non‐A–E hepatitis: Possible role of hepatitis B and C virus infection

Zhang

Wang

et al. 2002

Journal of Medical Virology

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In an effort to determine the cause of non-A-E hepatitis, a retrospective study was undertaken on a group of patients with hepatitis but without serological infection markers of hepatitis viruses A-E. A total of 60 patients admitted to Beijing Ditan Hospital during the period of September 1997 and September 1999 were chosen for this study. These patients were diagnosed as either acute or chronic hepatitis, but no serological markers of hepatitis viruses A-E were detected. Since TT virus (TTV), human parvovirus B19 (B19), SEN virus (SENV), and GB virus C/HGV were reported to be associated with hepatitis, attempts were made to detect the presence of these viruses in the sera of patients with non-A-E hepatitis by a nested polymerase chain reaction (nPCR) method. Also, more sensitive nPCR and RT-nPCR methods were used to determine HBV DNA and HCV RNA in these patients. Results derived from these analyses demonstrate that HBV DNA was detected in most of these patients (47/60, 78.3%), suggesting that HBV infection played a major role in occult non-A-E hepatitis and detection of HBV DNA by more sensitive PCR methods such as nPCR should be considered for diagnosis of HBV infection. In addition, HCV RNA was detected in three (5%) of these patients. However, GBV-C (HGV) RNA was not detected, and TTV, B19, and SENV appear not to be associated with non-A-E hepatitis, as the prevalence rates of these viruses in patients with non-A-E hepatitis were similar to those in patients with viral hepatitis A-E. The results from this study indicate that co-infection of TTV or B19 with HBV did not increase the severity of the disease.

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Section: Discussionmentioning

confidence: 99%

Retrospective analysis of non‐A–E hepatitis: Possible role of hepatitis B and C virus infection

Zhang

Wang

et al. 2002

Journal of Medical Virology

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“…SEN virus (SENV) is a recently discovered small single-stranded, circular, nonenveloped DNA virus family of about 3,600–3,900 nucleotides, possessing at least three open-reading frames [1, 2]. Phylogenetic analysis [3] has shown eight strains of SENV to be members of the family, which also includes the TT virus (TTV) [4, 5].…”

Section: Introductionmentioning

confidence: 99%

“…Clinical manifestations are diverse, ranging from very mild to profound anemia, such as β-thalassemia major, which if untreated is fatal in early childhood. Regular red blood cell transfusion is the main palliative treatment, if there are no suitable donors for bone marrow transplantation [2,3,4]. Hemoglobin H disease is a form of moderate to severe α-thalassemia which may require frequent red blood cell transfusion in some patients to maintain adequate hemoglobin levels when treating severe anemia, permitting better growth and development [12, 13].…”

Section: Introductionmentioning

confidence: 99%

SEN and Hepatitis Virus Infections in Nontransfused Children and Pediatric Thalassemia Patients with Multiple Transfusions in Taiwan

Chiou

Huang²,

Chang³

et al. 2006

Digestion

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Background: SouthernTaiwan is a hepatitis B and C viruses (HBV, HCV) endemic area. SEN virus (SENV) infection has been suggested as transfusion-related hepatitis. Two variants of SENV (SENV-D and SENV-H) have been studied in non-transfused children and transfusion-dependent thalassemia patients. Methods: Sera of 67 non-transfused children and 55 pediatric thalassemia patients with multiple transfusions were tested for SENV-D and SENV-H DNAs, liver function, iron status, HBV and HCV markers. Results: The prevalence of SENV (D or H), SENV-D, SENV-H infection, and SENV-D/H coinfection was significantly lower in nontransfused children than in thalassemia patients (22.4, 20.9, 5.0 and 1.5%, respectively, versus 67.3, 52.7, 40.0 and 25.5%, respectively, p < 0.001). The serum alanine aminotransferase (ALT) levels in thalassemia patients with SENV infection alone were significantly lower than levels in patients with SENV/HCV co-infection (p < 0.05), but not different when compared with those without SENV/HCV infection. SENV viremia was not associated with elevated ALT levels in thalassemia patients. SENV viremia did not increase the risk of HCV infection in thalassemia patients. Conclusions: SENV infection is high among non-transfused controls in Taiwan. Transfusion significantly increases the relevance of SENV infection. SENV viremia was not associated with the ALT levels in thalassemia patients.

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“…Until now, however, none of them has been proved to be the cause of hepatitis and, as yet, have still to be identified with any pathology [6,7]. The oldest of them, the GBV, has recently been associated with longer survival in HIV-infected subjects [8,9], although, in this case, contradictory data have been presented [10,11] and only persistent viremia seems to control HIV disease progression [12].…”

mentioning

confidence: 99%

“…Epidemiological studies have given inconsistent results concerning chronicity and clearance of viremia, with very fluctuating lengths in periods of recurrent viremia in the case of all of these viruses (SENV, GBV or TTV) [2,5,6,12]. So far, a marker of resolved infection has been described only for GBV (i.e., anti-E2 antibodies) [13].…”

mentioning

confidence: 99%

Modifications in SENV DNA Detection and/or SENV Subtype Determination over a Prospective Follow-Up in a Cohort of HIV-Positive Patients: Is This a Moving Target?

Quiros-Roldan

Torti²,

Pirovano³

et al. 2004

Intervirology

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SEN virus (SENV) is a new family of single-stranded DNA viruses with eight different strains, A–H. The modifications in SENV DNA detection and subtype distribution were studied over a long-term follow-up (48 ± 32.5 months) in 52 HIV-infected patients. 46% of the patients in the first sample and 34.6% in the second sample were found to have detectable SENV viremia. While the most prevalent variant in the first sample was found to be genotype A (83.3%), the second sample revealed a broader subtype diversification. Several epidemiological and clinical variables were tested in univariate model for clearance of detectable SENV viremia, but none of them reached statistical significance. In conclusion, a high degree of instability of both SENV DNA detection and subtype distribution in a cohort of HIV-infected patients was suggested, which may have important implications for further studies on both SENV epidemiology and its clinical impact.

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New hepatitis viruses: Contenders and pretenders

Cited by 36 publications

References 74 publications

Retrospective analysis of non‐A–E hepatitis: Possible role of hepatitis B and C virus infection

Retrospective analysis of non‐A–E hepatitis: Possible role of hepatitis B and C virus infection

SEN and Hepatitis Virus Infections in Nontransfused Children and Pediatric Thalassemia Patients with Multiple Transfusions in Taiwan

Modifications in SENV DNA Detection and/or SENV Subtype Determination over a Prospective Follow-Up in a Cohort of HIV-Positive Patients: Is This a Moving Target?

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