New host species for Leptospira borgpetersenii and Leptospira interrogans serovar Copenhageni

Colombo, Valeria; Gamietea, Ignacio José; Löffler, Sylvia Grune; Brihuega, Bibiana; Beldoménico, Pablo Martín

doi:10.1016/j.vetmic.2018.01.007

Cited by 15 publications

(13 citation statements)

References 15 publications

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“…We found relatively high seroprevalences in the species for which we had a good sample size: O. flavescens (55%), A. azarae (42.9%) and S. aquaticus (41.3%). These results, together with those on our previous report [11] [10] suggest that pathogenic leptospires are circulating among sigmodontines of central-eastern Table 2. Candidate conditional logistic regression models to explain variation in ELISA seropositivity using site as stratum (n = 85).…”

Section: Discussionsupporting

confidence: 85%

“…Murid rodents of the species Mus musculus, Rattus norvegicus and Rattus rattus (Muridae: Murinae) are maintenance hosts of the serovars Icterohaemorrhagiae, Copenhageni and Ballum [4,5]. In recent years, some species of South American sigmodontine rodents (Cricetidae: Sigmodontinae) were also reported as renal carriers of Leptospira [6][7][8][9][10][11][12]. Introduced and native rodent species usually cohabit and seek food and shelter in the proximity of households, becoming an important source of infection for humans and domestic animals [4,6].…”

Section: Introductionmentioning

confidence: 99%

“…Several species of rodents reside in this area, including cavys (Cavia aperea), sigmodontines, murines, and the introduced squirrel Callosciurus erythraeus (Sciuridae) [21,22]. Leptospiral infection was reported in Argentina for the four introduced species [7,14,[23][24][25][26][27][28] and for the native sigmodontines Akodon azarae, Holochilus vulpinus, Oligoryzomys flavescens, Oligoryzomys nigripes and Scapteromys aquaticus [7,10,23]. In a previous publication, we reported renal carriage of Leptospira interrogans in one individual of S. aquaticus from Santa Fe [11].…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of leptospiral antibodies in rodents from riverside communities of Santa Fe, Argentina

et al. 2020

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Background Leptospirosis is a zoonotic disease that can be transmitted by contact with the urine of infected mammals. Rodents play a mayor role in the transmission of leptospires to humans. The province of Santa Fe reports the greatest number of cases in Argentina. Yet, in this region, there are still knowledge gaps regarding the diversity of rodent species that may be hosts of pathogenic leptospires. The aims of this study were to evaluate the presence of leptospiral antibodies in rodents from three riverside communities of Santa Fe, and to identify factors associated with leptospiral infection. Methodology/Principal findings Each community was divided into three environmental settings based on the level of human disturbance, and sampled during two springs (Sep-Oct 2014 and 2015) and one autumn (Mar-Apr 2015). Serum samples of captured sigmodontine and murine rodents were tested for leptospiral antibodies by enzyme-linked immunosorbent assay (ELISA), and microagglutination test (MAT) was used to assess the infecting serovar in seropositive individuals. Factors influencing seropositivity were analyzed using logistic regression models. We caught 119 rodents, of which 101 serums were suitable for analysis. Most frequently trapped species were Scapteromys aquaticus, Akodon azarae and Oligoryzomys spp., with seroprevalences of 41.3%, 42.9% and 55% respectively. Seropositivity was higher in individuals with an average body condition score and in those that were sexually mature, but in the latter the differences were marginally significant.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of leptospiral antibodies in rodents from riverside communities of Santa Fe, Argentina

et al. 2020

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“…The reference serovar of L. borgspetersenii isolated from M. musculus is Ballum, which was detected in the past century in Europe (Yager et al 1953). Since then, multiple serological and molecular studies have shown that this serovar is widely distributed across M. musculus populations worldwide (da Silva et al 2010;Matsui et al 2015;Colombo et al 2018). In México, studies conducted in the state of Durango have reported titers of antibodies to the L. borgspetersenii Ballum serovar in domestic animals such as pigs and donkeys Cruz-Romero et al 2018).…”

Section: Discussionmentioning

confidence: 99%

“…In particular, rodents play a role as reservoirs; many murine species exhibit chronic infections and continually release bacteria in urine, a phenomenon called leptospiruria. Members of the family Muridae serve as the main reservoirs of Leptospira sp., and are deemed responsible for spreading the infection to livestock, pets, and humans (da Silva et al 2010;Colombo et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Molecular evidence for the presence of Leptospira borgpetersenii in synanthropic rodents in the Nautla region, Veracruz, México

Gutiérrez-Molina

Cruz‐Romero

Romero-Salas

et al. 2019

Therya

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The genus Leptospira encompasses ten species of spirochetes capable of infecting mammals, particularly rodents. In México, studies focused on the detection of Leptospira sp. in rodents are scarce, all of them restricted to three states of the Gulf of México. For this reason, this work aimed to identify the diversity of Leptospira species associated with synanthropic rodents in Veracruz, a state where leptospirosis is endemic. Rodents were sampled with Sherman traps placed in 10 Production Units across the Nautla region. Animals were euthanized and their kidneys removed. Subsequently, a 474-bp segment of the outer membrane protein LipL32, present in all pathogenic species, was amplified and sequenced. Sequences were compared vs. reference using the BLAST algorithm: a phylogenetic reconstruction was carried out using the Maximum Likelihood method. In addition, the prevalence of infection in each Production Unit was estimated. Twenty eight rodents of a single species (Mus musculus) were caught. Leptospira DNA was detected in 17 samples (62.9 %, CI 95 % 42.3 to 80.6) from seven localities in the Nautla region. The sequences recovered exhibited 99-100% identity to each other and 99 % identity with Leptospira borgspetersenii sequences deposited in GenBank. This study confirms the presence of L. borgspetersenii in rodents, particularly in M. musculus, in México. This study increases the inventory of pathogenic leptospires for the state of Veracruz to three species.El género Leptospira engloba 10 especies de espiroquetas capaces de infectar mamíferos, particularmente roedores. En México se han realizado escasos estudios para la detección de Leptospira sp. en roedores, todos ellos restringidos a tres estados del Golfo de México. Por tal motivo el objetivo del presente trabajo fue identificar la diversidad de leptospiras en roedores sinantrópicas de Veracruz, un estado endémico de leptospirosis. Para la colecta de roedores, se colocaron trampas tipo Sherman en 10 unidades de producción de la región Nautla. Los animales se sacrificaron y se obtuvieron los riñones. Posteriormente se amplificó y secuenció un segmento de 474 pb de la proteína exterior de membrana LipL32 presente en las leptospiras patógenas. Posteriormente se compararon las secuencias con las de referencia mediante el uso del algoritmo BLAST y se realizó una reconstrucción filogenética mediante el método de Máxima Verosimilitud. Adicionalmente se obtuvieron las prevalencias de la infección por unidad de producción. Se colectaron 28 roedores de una única especie (Mus musculus). Se detectó la presencia de ADN de Leptospira en 17 muestras (62.9 %; IC 95 % 42.3 a 80.6) procedentes de siete localidades de la región Nautla. Las secuencias recuperadas exhibieron una similitud del 99-100 % entre si y una identidad del 99 % con secuencias de referencia de Leptospira borgspetersenii depositadas en GenBank. Este estudio confirma la presencia de L. borgspetersenii en roedores y en particular con M. musculus en México. Este estudio incrementa a tres especies el inventario ...

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Ecological factors shaping the ectoparasite community assembly of the Azara’s Grass Mouse, Akodon azarae (Rodentia: Cricetidae)

et al. 2023

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New host species for Leptospira borgpetersenii and Leptospira interrogans serovar Copenhageni

Cited by 15 publications

References 15 publications

Seroprevalence of leptospiral antibodies in rodents from riverside communities of Santa Fe, Argentina

Seroprevalence of leptospiral antibodies in rodents from riverside communities of Santa Fe, Argentina

Molecular evidence for the presence of Leptospira borgpetersenii in synanthropic rodents in the Nautla region, Veracruz, México

Ecological factors shaping the ectoparasite community assembly of the Azara’s Grass Mouse, Akodon azarae (Rodentia: Cricetidae)

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