New insight of immuno-engineering in osteoimmunomodulation for bone regeneration

Ouyang, Long; Dai, Qiang; Qiu, Daojing

doi:10.1016/j.reth.2021.03.003

Cited by 22 publications

(8 citation statements)

References 73 publications

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“…Therefore, combination of two or more such techniques could be a promising tool in future regenerative medicine. [161][162][163] The main limitation of this review is that heterogeneity of the biomaterials, cell types, animals, and experimental conditions of the concerned studies hampers a comparison between the various surface modification techniques for the control of inflammation. In the future, a greater understanding of macrophage polarization and induction of other inflammatory-immune cascades triggered in response to specific surface properties of biomaterial scaffolds will be highly instrumental in the therapeutic modulation of inflammation through optimization of biomaterial surface properties.…”

Section: Discussionmentioning

confidence: 99%

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

et al. 2021

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Control of inflammation is indispensable for optimal oral wound healing and tissue regeneration. Several biomaterials have been used to enhance the regenerative outcomes; however, the biomaterial implantation can ensure an immune-inflammatory response. The interface between the cells and the biomaterial surface plays a critical role in determining the success of soft and hard tissue regeneration. The initial inflammatory response upon biomaterial implantation helps in tissue repair and regeneration, however, persistant inflammation impairs the wound healing response. The cells interact with the biomaterials through extracellular matrix proteins leading to protein adsorption followed by recruitment, attachment, migration, and proliferation of several immune-inflammatory cells. Physical nanotopography of biomaterials, such as surface proteins, roughness, and porosity, is crucial for driving cellular attachment and migration. Similarly, modification of scaffold surface chemistry by adapting hydrophilicity, surface charge, surface coatings, can down-regulate the initiation of pro-inflammatory cascades. Besides, functionalization of scaffold surfaces with active biological molecules can down-regulate pro-inflammatory and pro-resorptive mediators’ release as well as actively up-regulate anti-inflammatory markers. This review encompasses various strategies for the optimization of physical, chemical, and biological properties of biomaterial and the underlying mechanisms to modulate the immune-inflammatory response, thereby, promoting the tissue integration and subsequent soft and hard tissue regeneration potential of the administered biomaterial.

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Section: Discussionmentioning

confidence: 99%

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

et al. 2021

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“…This stimulates Th1 cells to release pro-inflammatory cytokines (e.g., TNF-α, TNF-β, and IFN-γ), leading to a Th1-type inflammatory response. M2 macrophages secrete VEGF and TGF-β to help Th2 cells release cytokines such as IL-4, IL-6, IL-10, and IL-13, resulting in the generation of Th2 cells with anti-inflammatory properties that aid in tissue healing [ 93 ]. Conversely, T cells are also required for the functional polarization of M0 macrophages to the pro-inflammatory M1 or anti-inflammatory M2 type [ 94 ].…”

Section: Immune Cells Regulation Of Osteogenesismentioning

confidence: 99%

Immunomodulation Effect of Biomaterials on Bone Formation

Zhao

Chu

et al. 2022

JFB

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Traditional bone replacement materials have been developed with the goal of directing the osteogenesis of osteoblastic cell lines toward differentiation and therefore achieving biomaterial-mediated osteogenesis, but the osteogenic effect has been disappointing. With advances in bone biology, it has been revealed that the local immune microenvironment has an important role in regulating the bone formation process. According to the bone immunology hypothesis, the immune system and the skeletal system are inextricably linked, with many cytokines and regulatory factors in common, and immune cells play an essential role in bone-related physiopathological processes. This review combines advances in bone immunology with biomaterial immunomodulatory properties to provide an overview of biomaterials-mediated immune responses to regulate bone regeneration, as well as methods to assess the bone immunomodulatory properties of bone biomaterials and how these strategies can be used for future bone tissue engineering applications.

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“…It has been found that MSCs can sustain the expression of the key immunomodulatory molecules, B7-H3/CD276 and MHC, class I, E when subjected to osteogenic, adipogenic and chondrogenic differentiation in vitro ( 79 ). Therefore, understanding the effects of biomaterials on the immunoregulatory properties of MSCs is becoming an increasingly important question to address ( 80 , 81 ). Recently, Liu and Sun ( 82 ) established a direct contact co-culture model consisting of hydrolyzed fish collagen treated-bone marrow-derived MSCs and RAW264.7 macrophages.…”

Section: Marine Collagen and Their Immunomodulatory Properties In Mes...mentioning

confidence: 99%

Application of marine collagen for stem‑cell‑based therapy and tissue regeneration (Review)

Liu

2021

Med Int

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tissue engineering and regenerative medicine is becoming an important component in modern biological scientific research. tissue engineering, a branch of regenerative medicine, is a field that is actively developing to meet the challenges presented in biomedical applications. this particularly applies to the research area of stem cells and biomaterials, due to both being pivotal determinants for the successful restoration or regeneration of damaged tissues and organs. Recently, the development of innovative marine collagen-based biomaterials has attracted attention due to the reported environmentally friendly properties, the lack of zoonotic disease transmission, biocompatibility, bioactivity, the lack of ethics-related concerns and cost-effectiveness for manufacturing. the present review aimed to summarize the potential application and function of marine collagen in stem cell research in a medical and clinical setting. In addition, the present review cited recent studies regarding the latest research advances into using marine collagen for cartilage, bone, periodontal and corneal regeneration. It also characterized the distinct advantages of using marine collagen for stem cell-based tissue repair and regeneration. In addition, the present review comprehensively discussed the most up to date information on stem cell biology, particularly the possibility of treating stem cells with marine collagen to maximize their multi-directional differentiation capability, which highlights the potential use of marine collagen in regenerative medicine. Furthermore, recent research progress on the potential immunomodulatory capacity of mesenchymal stem cells following treatment with marine collagen to improve the understanding of cell-matrix interactions was investigated. Finally, perspectives on the possible future research directions for the application of marine collagen in the area of regenerative medicine are provided.

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New insight of immuno-engineering in osteoimmunomodulation for bone regeneration

Cited by 22 publications

References 73 publications

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

Immunomodulation Effect of Biomaterials on Bone Formation

Application of marine collagen for stem‑cell‑based therapy and tissue regeneration (Review)

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