New Insights from Metabolomics in Pediatric Renal Diseases

Riccio, Simona; Valentino, Maria Sole; Passaro, Antonio Paride; Izzo, M.; Guarino, Stefano; Giudice, Emanuele Miraglia del; Marzuillo, Pierluigi; Sessa, Anna Di

doi:10.3390/children9010118

Cited by 9 publications

(4 citation statements)

References 90 publications

(145 reference statements)

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“…Consistent with our finding, it has been reported that N6-carbamoylthreonyladenosine was significantly associated with systolic blood pressure ( 41 ). It has been identified as a biomarker for chronic kidney disease progression in children ( 50 , 51 ) and highly correlated with glomerular filtration rate ( 52 ). Hypertension can often lead to end organ damage including renal dysfunction and chronic kidney disease ( 53 ).…”

Section: Discussionmentioning

confidence: 99%

Metabolomic profiling reveals key metabolites associated with hypertension progression

Al Ashmar,

Anwardeen,

Anlar

et al. 2024

Front. Cardiovasc. Med.

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IntroductionPre-hypertension is a prevalent condition among the adult population worldwide. It is characterized by asymptomatic elevations in blood pressure beyond normal levels but not yet reaching the threshold for hypertension. If left uncontrolled, pre-hypertension can progress to hypertension, thereby increasing the risk of serious complications such as heart disease, stroke, kidney damage, and others.ObjectiveThe precise mechanisms driving the progression of hypertension remain unknown. Thus, identifying the metabolic changes associated with this condition can provide valuable insights into potential markers or pathways implicated in the development of hypertension.MethodsIn this study, we utilized untargeted metabolomics profiling, which examines over 1,000 metabolites to identify novel metabolites contributing to the progression from pre-hypertension to hypertension. Data were collected from 323 participants through Qatar Biobank.ResultsBy comparing metabolic profiles between pre-hypertensive, hypertensive and normotensive individuals, six metabolites including stearidonate, hexadecadienoate, N6-carbamoylthreonyladenosine, 9 and 13-S-hydroxyoctadecadienoic acid (HODE), 2,3-dihydroxy-5-methylthio- 4-pentenoate (DMTPA), and linolenate were found to be associated with increased risk of hypertension, in both discovery and validation cohorts. Moreover, these metabolites showed a significant diagnostic performance with area under curve >0.7.ConclusionThese findings suggest possible biomarkers that can predict the risk of progression from pre-hypertension to hypertension. This will aid in early detection, diagnosis, and management of this disease as well as its associated complications.

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Section: Discussionmentioning

confidence: 99%

Metabolomic profiling reveals key metabolites associated with hypertension progression

Al Ashmar,

Anwardeen,

Anlar

et al. 2024

Front. Cardiovasc. Med.

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“…Metabolites, such as amino acids, sugars, and lipids, are intermediate or end products of cellular metabolism. Metabolomic analysis of biological fluids (e.g., blood and urine) has shown promise as a method for novel biomarker discovery in kidney disease [[15], [16]]. Two main analytical platforms used are magnetic resonance spectroscopy and mass spectrometry, usually coupled with modern separation techniques (such as liquid/gas chromatography), to provide qualitative and quantitative descriptions of metabolites in biological systems.…”

Section: Metabolomics In Ckdmentioning

confidence: 99%

Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease

Sandokji¹,

Xu²,

Furth³

et al. 2023

Nephron

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Background: Due to the complexity of chronic kidney disease (CKD) pathophysiology, biomarkers representing different mechanistic pathways have been targeted for the study and development of novel biomarkers. The discovery of clinically useful CKD biomarkers would allow for the identification of those children at the highest risk of kidney function decline for timely interventions and enrollment in clinical trials. Summary: Glomerular filtration rate and proteinuria are traditional biomarkers to classify and prognosticate CKD progression in clinical practice but have several limitations. Over the recent decades, novel biomarkers have been identified from blood or urine with metabolomic screening studies, proteomic screening studies, and an improved knowledge of CKD pathophysiology. This review highlights promising biomarkers associated with the progression of CKD that could potentially serve as future prognostic markers in children with CKD. Key Messages: Further studies are needed in children with CKD to validate putative biomarkers, particularly candidate proteins and metabolites, for improving clinical management.

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“…Using this technology in a mouse model of AKI, authors concluded that the maladaptive repair in tubular cells is characterized by differences in production of lactate, which could possibly be the result of higher glycolytic activity and, as injury progresses, a concomitant reduction of the tricarboxylic acid (TCA) cycle metabolite consumption [ 34 ]. Over the past decades, metabolomics has added a promising number of new biomarkers through better pathophysiology knowledge, paving the way for insightful perspectives on the management of different kidney diseases [ 35 ]. However, the metabolome greatly varies with age, diet, drug consumption, lifestyle, and, in adults, with gender, making it difficult to compare studies in adults and in children and neonates.…”

Section: Fundamental Research Pushes Forward the Field Of Regenerativ...mentioning

confidence: 99%

Advances and potential of regenerative medicine in pediatric nephrology

et al. 2023

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The endogenous capacity of the kidney to repair is limited, and generation of new nephrons after injury for adequate function recovery remains a need. Discovery of factors that promote the endogenous regenerative capacity of the injured kidney or generation of transplantable kidney tissue represent promising therapeutic strategies. While several encouraging results are obtained after administration of stem or progenitor cells, stem cell secretome, or extracellular vesicles in experimental kidney injury models, very little data exist in the clinical setting to make conclusions about their efficacy. In this review, we provide an overview of the cutting-edge knowledge on kidney regeneration, including pre-clinical methodologies used to elucidate regenerative pathways and describe the perspectives of regenerative medicine for kidney patients.

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New Insights from Metabolomics in Pediatric Renal Diseases

Cited by 9 publications

References 90 publications

Metabolomic profiling reveals key metabolites associated with hypertension progression

Metabolomic profiling reveals key metabolites associated with hypertension progression

Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease

Advances and potential of regenerative medicine in pediatric nephrology

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