1999
DOI: 10.1016/s1368-8375(98)00051-7
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New insights into p53 protein stabilisation in oral squamous cell carcinoma

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Cited by 50 publications
(43 citation statements)
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“…Here, by sequencing all the 10 coding exons of a larger group of adrenocortical tumors, we showed that TP53 somatic mutations are present in a third of the tumors. As shown for other type of tumors (17,29,30), most of the TP53 mutations are within exons 5 to 8 (11 of 13 mutations), corresponding to the core-binding domain of the p53 protein. A previous study showed an important percentage of mutations located in exon 4 in adrenal adenomas of Taiwanese patients (31), which was not confirmed in another study of adrenocortical tumors from Europe (32).…”
Section: Discussionmentioning
confidence: 82%
“…Here, by sequencing all the 10 coding exons of a larger group of adrenocortical tumors, we showed that TP53 somatic mutations are present in a third of the tumors. As shown for other type of tumors (17,29,30), most of the TP53 mutations are within exons 5 to 8 (11 of 13 mutations), corresponding to the core-binding domain of the p53 protein. A previous study showed an important percentage of mutations located in exon 4 in adrenal adenomas of Taiwanese patients (31), which was not confirmed in another study of adrenocortical tumors from Europe (32).…”
Section: Discussionmentioning
confidence: 82%
“…These data suggest that increased levels of MDM2 may substitute for mutations in p53, which represents an alternative mechanism by which tumor cells escape from the tumor suppressive activities of p53. In HNSC, overexpression of MDM2 has been observed [15][16], but a clear correlation between the levels of MDM2 protein and p53 status has not been established [17].…”
Section: Introductionmentioning
confidence: 99%
“…A study of the relation between expression of wildtype p53 and genetic aberrations found that p53-positive tumors had a higher allelic imbalance (15). Even limited exposure to tobacco carcinogens is thought to have a mutagenic effect on TP53 (6).…”
Section: Discussionmentioning
confidence: 99%