New insights into the link between cardiovascular disease and depression

Mosovich, Serge; Boone, R. Thomas; Reichenberg, Abraham; Bansilal, Sameer; Shaffer, Jonathan A.; Dahlman, Karen; Harvey, P.; Farkouh, Michael E.

doi:10.1111/j.1742-1241.2007.01640.x

Cited by 50 publications

(30 citation statements)

References 79 publications

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“…53 Mosovich et al have proposed a new model, where depression and CVD share a common underlying cause, and both diseases are possible outcomes of prior stress-related insult to the body. 53 In that model, local and systemic events, mediated by immune intercellular messengers, would lead to neurotoxicity and disrupted production of serotonin, which in turn would cause depression and increase platelet aggregation.…”

Section: Discussionmentioning

confidence: 99%

Pathophysiological basis of cardiovascular disease and depression: a chicken-and-egg dilemma

Paz-Filho

Licinio

Wong

2010

Rev. Bras. Psiquiatr.

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Objective To describe the pathophysiological basis linking cardiovascular disease (CVD) and depression; to discuss the causal relationship between them, and to review the effects of antidepressant treatment on cardiovascular disease. Method A review of the literature based on the PubMed database. Discussion Depression and cardiovascular disease are both highly prevalent. Several studies have shown that the two are closely related. They share common pathophysiological etiologies or co-morbidities, such as alterations in the hypothalamic-pituitary axis, cardiac rhythm disturbances, and hemorheologic, inflammatory and serotoninergic changes. Furthermore, antidepressant treatment is associated with worse cardiac outcomes (in case of tricyclics), which are not observed with selective serotonin reuptake inhibitors. Conclusion Although there is a strong association between depression and cardiovascular disease, it is still unclear whether depression is actually a causal factor for CVD, or is a mere consequence, or whether both conditions share a common pathophysiological etiology. Nevertheless, both conditions must be treated concomitantly. Drugs other than tricyclics must be used, when needed, to treat the underlying depression and not as mere prophylactic of cardiac outcomes.

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Section: Discussionmentioning

confidence: 99%

Pathophysiological basis of cardiovascular disease and depression: a chicken-and-egg dilemma

Paz-Filho

Licinio

Wong

2010

Rev. Bras. Psiquiatr.

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“…In addition, because stress could lead to depression, thereby resulting in increased incidence of sepsis, we also sought to determine if the presence of depressive symptoms explained the association between stress and sepsis. (5, 8, 9)…”

Section: Introductionmentioning

confidence: 99%

Psychosocial Stress as a Risk Factor for Sepsis

Ojard

Donnelly

Safford

et al. 2015

Psychosomatic Medicine

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OBJECTIVE To characterize the relationship between stress and future risk of sepsis. We also evaluated the role of depression in this relationship. METHODS We used population-based data on 30,183 participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, characterizing stress using the Perceived Stress Scale (PSS) and depressive symptoms using the Center for Epidemiologic Studies Depression Scale (CES-D). We identified incident sepsis events as hospitalizations for a serious infection with the presence of ≥2 SIRS criteria. We assessed associations between PSS and incidence of sepsis over one- and ten-years of follow-up, adjusting for demographics and chronic medical conditions and assessing the role of health behaviors and CES-D in these relationships. RESULTS During 2003–2012, 1,500 participants experienced an episode of sepsis. Mean PSS and CES-D scores were 3.2±2.9 and 1.2±2.1. PSS was associated with increased one-year adjusted incidence of sepsis (HR 1.21 per PSS standard deviation; 95% CI: 1.06–1.38); multivariable adjustment for health behaviors and CES-D did not change this association (1.20; 1.20; 1.03–1.39). PSS was also associated with increased 10-year adjusted incidence of sepsis (HR 1.07 per PSS standard deviation; 95% CI: 1.02–1.13). Multivariable adjustment showed that health behaviors did not affect this long-term association whereas addition of CES-D reduced the association between PSS and sepsis during 10-year follow-up (HR 1.04; 0.98–1.11). CONCLUSIONS Increased stress was associated higher one-year adjusted incidence of sepsis, even after accounting for depressive symptoms. The association between stress and ten-year adjusted incidence of sepsis was also significant, but this association was reduced when adjusting for depressive symptoms. Reduction of stress may limit short-term sepsis risk.

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“…В качестве индуктора «патологической цепочки» можно рассмотреть стресс, который запускает каскад локальных и системных событий, опосредованных иммунными клеточными мессенджерами, ведущими к развитию нейротоксичности и снижению продукции се-ротонина [51]. В качестве стресса может выступить любой фактор внешней или внутренней среды, а одним из вари-антов защиты -реакция макрофагов, циркулирующих как в сосудистом русле, так и глиальных клетках мозга.…”

Section: Discussionunclassified

Comorbidity of depressive disorders and coronary heart disease: general aspects of pathogenesis

Незнанов

Козлова

Мазо

et al. 2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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New insights into the link between cardiovascular disease and depression

Abstract: If the proposed model holds true, it may be possible that an intervention initiated before overt manifestations of CVD or depression become apparent, may delay or prevent the onset of these serious clinical entities.

Cited by 50 publications

References 79 publications

Pathophysiological basis of cardiovascular disease and depression: a chicken-and-egg dilemma

Pathophysiological basis of cardiovascular disease and depression: a chicken-and-egg dilemma

Psychosocial Stress as a Risk Factor for Sepsis

Comorbidity of depressive disorders and coronary heart disease: general aspects of pathogenesis

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