New Insights into the Man-Mouse Comparative Map of the X Chromosome

Blair, Helen J.; Reed, Vivienne; Laval, Steven H.; Boyd, Yvonne

doi:10.1006/geno.1994.1050

Cited by 38 publications

(21 citation statements)

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“…Looking over these mapping data, it is evident that the comparative mapping of Xp22.3 loci extends the recently suggested model for the evolution of mammalian X chromosomes by Blair et al (1994). Rather than supporting the assumption of eight conserved X chromosomal regions being rearranged during mammalian evolution, data on Xp22.3 loci implicate a much more complex sequence of events leading to the divergence of the X chromosomes between man and mouse.…”

Section: Discussionmentioning

confidence: 52%

Man to Mouse—Lessons Learned from the Distal End of the Human X Chromosome

Blaschke¹,

Rappold²

1997

Genome Res.

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Section: Discussionmentioning

confidence: 52%

Man to Mouse—Lessons Learned from the Distal End of the Human X Chromosome

Blaschke¹,

Rappold²

1997

Genome Res.

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“…Moreover, the complex nature of the rearrangements inferred in Figures 4 and 5 means that it can be difficult to predict the location of homologous genes unless detailed comparative map information is available. We finally note that conserved synteny but frequent internal rearrangements are also a hallmark of mammalian X chromosome evolution (Blair et al 1994;Millwood et al 1997;Bourque et al 2004).…”

Section: Discussionmentioning

confidence: 85%

Genetic Mapping in a Natural Population of Collared Flycatchers (Ficedula albicollis): Conserved Synteny but Gene Order Rearrangements on the Avian Z Chromosome

Backström¹,

Brandström²,

Gustafsson

et al. 2006

Genetics

100

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Data from completely sequenced genomes are likely to open the way for novel studies of the genetics of nonmodel organisms, in particular when it comes to the identification and analysis of genes responsible for traits that are under selection in natural populations. Here we use the draft sequence of the chicken genome as a starting point for linkage mapping in a wild bird species, the collared flycatcher-one of the most well-studied avian species in ecological and evolutionary research. A pedigree of 365 flycatchers was established and genotyped for single nucleotide polymorphisms in 23 genes selected from (and spread over most of ) the chicken Z chromosome. All genes were also found to be located on the Z chromosome in the collared flycatcher, confirming conserved synteny at the level of gene content across distantly related avian lineages. This high degree of conservation mimics the situation seen for the mammalian X chromosome and may thus be a general feature in sex chromosome evolution, irrespective of whether there is male or female heterogamety. Alternatively, such unprecedented chromosomal conservation may be characteristic of most chromosomes in avian genome evolution. However, several internal rearrangements were observed, meaning that the transfer of map information from chicken to nonmodel bird species cannot always assume conserved gene orders. Interestingly, the rate of recombination on the Z chromosome of collared flycatchers was only 50% that of chicken, challenging the widely held view that birds generally have high recombination rates.

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“…Notwithstanding the high degree of conservation, the rearranged order of genes on the X chromosome suggests intrachromosomal rearrangements (Nadeau 1989;Farr and Goodfellow 1992). Recent studies showing over eight conserved Xchromosomal regions being rearranged between human and mouse (Blair et al 1994;Carver and Stubbs 1997), and an additional nine just within the distal 12 Mb of HSAXp22.3 (Blaschke and Rappold 1997), indicate a much more complex sequence of events leading to the divergent organization of the X chromosomes of these two species.…”

Section: Conservation Of Whole Chromosome Syntenymentioning

confidence: 99%

Emerging Patterns of Comparative Genome Organization in Some Mammalian Species as Revealed by Zoo-FISH

Chowdhary¹,

Raudsepp²,

Frönicke³

et al. 1998

Genome Res.

212

143

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Although gene maps for a variety of evolutionarily diverged mammalian species have expanded rapidly during the past few years, until recently it has been difficult to precisely define chromosomal segments that are homologous between species. A solution to this problem has come from the development of Zoo-FISH, also known as cross-species chromosome painting. The use of Zoo-FISH to identify regions of chromosomal homology has allowed the transfer of information from map-rich species such as human and mouse to a wide variety of other species. From a Zoo-FISH analysis spanning four mammalian orders (Primates, Artiodactyla, Carnivora, and Perissodactyla), and involving eight species (human, pig, cattle, Indian muntjac, cat, American mink, harbor seal, and horse), three distinct classes of synteny conservation have been designated: (1) conservation of whole chromosome synteny, (2) conservation of large chromosomal blocks, and (3) conservation of neighboring segment combinations. This analysis has also made it possible to identify a set of chromosome segments (based on human chromosome equivalents) that probably made up the karyotype of the common ancestor of the four orders. This approach provides a basis for developing a picture of the ancestral mammalian karyotype, but a full understanding will depend on studies encompassing more diverse combinations of mammalian orders.

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New Insights into the Man-Mouse Comparative Map of the X Chromosome

Cited by 38 publications

References 0 publications

Man to Mouse—Lessons Learned from the Distal End of the Human X Chromosome

Man to Mouse—Lessons Learned from the Distal End of the Human X Chromosome

Genetic Mapping in a Natural Population of Collared Flycatchers (Ficedula albicollis): Conserved Synteny but Gene Order Rearrangements on the Avian Z Chromosome

Emerging Patterns of Comparative Genome Organization in Some Mammalian Species as Revealed by Zoo-FISH

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