New insights into the possible role of bacteriophages in transplantation

Górski, Andrzej; Nowaczyk, M; Weber‐Dąbrowska, Beata; Kniotek, Monika; Boratyński, Janusz; Ahmed, Aabid; Dąbrowska, Krystyna; Wierzbicki, Piotr; Świtała-Jeleń, Kinga; Opolski, Adam

doi:10.1016/s0041-1345(03)00811-x

Cited by 38 publications

(45 citation statements)

References 6 publications

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“…126,127 The binding is believed to be at least partially responsible for the immunosuppressive and anti-tumor activities of the phage preparation in vivo and in vitro. 128 Gorski et al 129 and Kniotek et al 130 have also documented the immunosuppressive activity of phages in the intestines when administered in vivo, inhibiting both humoral and cell-mediated immunity. Thus, intestinal phages may not only eliminate harmful bacteria and reduce commensal bacteria but may also modulate local immune reactions directly themselves.…”

Section: Direct Phage Effects On the Mammalian Host Immune Systemmentioning

confidence: 99%

Movers and shakers

et al. 2013

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Section: Direct Phage Effects On the Mammalian Host Immune Systemmentioning

confidence: 99%

Movers and shakers

et al. 2013

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“…Furthermore, the phenomenon future science group www.futuremedicine.com of translocation can enable phages to migrate to distant tissues and interact with cells of the immune system locally and at other sites [13]. We postulated that at least some phages (e.g., T4) could interact with cells of the immune system using the Lys-Gly-Asp (KGD) sequence present in the capsid protein gp24 and the respective cellular receptor β-3 integrin also used by some pathogenic viruses [14]. Interestingly, this sequence is also present within the CD40 ligand, known to activate endothelium and platelets, and stimulate inflammation, and is crucial for T-and B-lymphocyte activation -the interruption of CD40-CD40L interactions has strong immunosuppressive properties.…”

Section: Phages and The Immune Systemmentioning

confidence: 99%

Phages and Immunomodulation

et al. 2017

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In the past years, the microbiome and its role in the pathophysiology of diseases have gained great interest. The progress of our knowledge in this field opens completely novel prospects for treating disorders, including those which are most challenging to medicine today. Of special interest are studies on the interactions of the microbiome with the immune system. Only recently has the presence of bacteriophages in the microbiome been highlighted, and their potential role in maintaining normal immunity has gained increasing attention. We summarize the available data pointing to the potential impact of phages in maintaining immunological homeostasis.

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“…Based on this basic information in phage biology, A. Górski postulated that KGD + phages should interact with the β-integrins that tumor cells express and that such interaction may result in the suppression of the tumor cells' locomotion and other biological activities [130]. The phage-tumor cell relationship may be more intimate than just an attachment of the phage particle to the cell surface.…”

Section: Bacteriophages Inhibit Tumor Metastasesmentioning

confidence: 99%

Natural and genetically engineered viral agents for oncolysis and gene therapy of human cancers

Sinkovics

Horváth

2008

Arch. Immunol. Ther. Exp.

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Based on personal acquaintances and experience dating back to the early 1950s, the senior author reviews the history of viral therapy of cancer. He points out the difficulties encountered in the treatment of human cancers, as opposed by the highly successful viral therapy of experimentally maintained tumors in laboratory animals, especially that of ascites carcinomas in mice. A detailed account of viral therapy of human tumors with naturally oncolytic viruses follows, emphasizing the first clinical trials with viral oncolysates. The discrepancy between the high success rates, culminating in cures, in the treatment of tumors of laboratory animals, and the moderate results, such as stabilizations of disease, partial responses, very rare complete remissions, and frequent relapses with virally treated human tumors is recognized. The preclinical laboratory testing against established human tumor cell lines that were maintained in tissue cultures for decades, and against human tumors extricated from their natural habitat and grown in xenografts, may not yield valid results predictive of the viral therapy applied against human tumors growing in their natural environment, the human host. Since the recent discovery of the oncosuppressive efficacy of bacteriophages, the colon could be regarded as the battlefield, where incipient tumor cells and bacteriophages vie for dominance. The inner environment of the colon will be the teaching ground providing new knowledge on the value of the anti-tumor efficacy of phage-induced innate anti-tumor immune reactions. Genetically engineered oncolytic viruses are reviewed next. The molecular biology of viral oncolysis is explained in details. Elaborate efforts are presented to elucidate how gene product proteins of oncolytic viruses switch off the oncogenic cascades of cancer cells. The facts strongly support the conclusion that viral therapy of human cancers will remain in the front lines of modern cancer therapeutics. It may be a combination of naturally oncolytic viruses and wild-type viruses rendered oncolytic and harmless by genetic engineering, that will induce complete remissions of human tumors. It may be necessary to co-administer certain chemotherapeutic agents, advanced cancer vaccines, or even immune lymphocytes, and targeted therapeuticals, to ascertain, that remissions induced by the viral agents will remain complete and durable; will co-operate with anti-tumor host immune reactions, and eventually will result in cures of advanced metastatic human cancers.

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New insights into the possible role of bacteriophages in transplantation

Cited by 38 publications

References 6 publications

Movers and shakers

Movers and shakers

Phages and Immunomodulation

Natural and genetically engineered viral agents for oncolysis and gene therapy of human cancers

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