New Insights on Naproxen Quantification Using Voltammetry and Graphite Electrodes: Development of an Optimized and Competitive Methodology

Aguilar-Lira, Guadalupe Yoselin; Álvarez-Romero, Giaan Arturo; Rojas-Hernándéz, Alberto; Páez-Hernández, María Elena; Rodríguez, José A.; Romero-Romo, M.

doi:10.1149/06445.0079ecst

Cited by 5 publications

(4 citation statements)

References 14 publications

(17 reference statements)

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“…Under CV conditions, the anodic peak at 0.999 V corresponds to naproxen oxidation with the formation of an intermediate carboxylic radical, followed by decarboxylation. The second anodic peak appeared at 1.249 V corresponding to another current maximum that possibly belongs to ketone (2-acetyl-6-methoxynaphthalene, AMN), which in agreement with more recent voltammetric studies discussed two one-electron transfers in oxidation of NAP in aqueous media [24, 26, 34, 35]. No cathodic peaks were recorded indicating the irreversibility of naproxen oxidation over the carbon paste electrode, the working electrode.…”

Section: Resultssupporting

confidence: 87%

“…Alternatively, Pt electrodes were suggested for anodic oxidation of naproxen [19]; the high background current with limited sensitivity and reproducibility due to contamination by the fouling products and impurities was reported [20]. Recently, other electrode materials were applied including boron-doped diamond [21, 22], gold electrode [23], glassy carbon [24], graphite electrode [25, 26], multiwall carbon nanotube-modified glassy carbon electrode (MWCNTs/GCE) [27, 28], and carbon paste electrodes modified with different nanomaterials [29–31] were reported.…”

Section: Introductionmentioning

confidence: 99%

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Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products

Hendawy

Salem

Abd-Elmonem

et al. 2019

Journal of Analytical Methods in Chemistry

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The present work describes a novel, simple, and fast electroanalytical methodology for naproxen (NAP) determination in pharmaceutical formulations and biological fluids in the presence of its degradation products. Carbon paste electrodes (CPEs) modified with different carbon nanomaterials, namely, glassy carbon powder (GCE), multiwall carbon nanotubes (MWCNTs), single-walled carbon nanotubes (SWCNTs), graphene nanosheets (Gr), and graphene oxides (GO) were tested. Comprehensive studies were performed on the electrode matrix composition including the nature of the pasting liquids, pH, carbon nanomaterials, and mode of electrode modification. Two anodic oxidation peaks were recorded at 0.890 and 1.18 V in 1 × 10−1 mol·L−1 phosphate buffer solution at pH 6. Oxidation of naproxen (NAP) is an irreversible diffusion-controlled process. Calibration plots were rectilinear in the concentration ranging from 0.067 to 1.0 µg·mL−1 with correlation coefficient 0.9979. Photodegradation of NAP resulted in disappearance of the oxidation peak at 1.18 V, allowing simultaneous determination of NAP in presence of its degradation product. The achieved high sensitivity and selectivity suggest the application of the proposed protocol for naproxen determination in pharmaceutical preparations and human blood plasma.

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Section: Resultssupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products

Hendawy

Salem

Abd-Elmonem

et al. 2019

Journal of Analytical Methods in Chemistry

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“…15,16 Electrochemical sensors prepared by modifying various electrodes to create selective regions specific to analytes are very useful for clinical, environmental, and biomechanical analysis. 17 Naproxen has been determined voltammetrically using various electrodes, including mercury, 18 platinum, 19,20 boron-doped diamond, 2,21 gold, 22 glassy carbon, 23 carbon nanofiber, 24 graphite, 25,26 multiwalled carbon nanotubes/glassy carbon 27,28 graphene oxide 29 and nanomaterial modified carbon paste [30][31][32] electrodes.…”

Section: Introductionmentioning

confidence: 99%

Determination of naproxen by using differential pulse voltammetry with poly (aniline-2-sulfonic acid) modified boron doped diamond electrode

Güngör

2022

Maced. J. Chem. Chem. Eng.

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In this study, an electrochemical sensor based on a boron doped diamond electrode (BDDE) was developed for the determination of naproxen (NAP) using a poly(aniline-2-sulfonic acid)/boron doped diamond electrode, p(A2SA/BDDE). Polymerization of A2SA was conducted in a water/acetonitrile (1:1) mixture containing 0.1 M sodium perchlorate (NaClO4) on bare BDDE and the electrochemical properties studied by cyclic voltammetry in ferricyanide/KNO3 solution. The prepared p(A2SA/BDDE) was used for detection of NAP. Effects of parameters such as monomer type and concentration, the number of cycles, and scan rate were investigated using differential pulse voltammetry (DPV) in phosphate buffer containing 0.75 mM NAP. The effect of electrolyte type and pH on DPV responses to NAP were also studied. The oxidative current peak stem from NAP concentration observed at 1.1 V potential. A linear calibration curve was obtained in the range of 0.05–1.00 mM NAP concentration. Correlation coefficient (R2), detection limit, and quantification limit were calculated as 0.9944, 0.0328 mM, and 0.1093 mM, respectively. In conclusion, it may be claimed that the modified electrode constructed in this work can be used successfully as a naproxen-selective membrane due to its ease of preparation, high R2 value, and good reproducibility.

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“…Electrochemical methods such as potentiometric technique 18,19 and voltammetric analysis for NAP monitoring have recently performed. The recent works describe the use of different electrode such as Pt, 20 graphite electrode, 21 boron-doped diamond electrode, 22 CNT-modified glassy carbon 23 and enzymatic biosensors 24 for voltammetric analysis of NAP.…”

mentioning

confidence: 99%

Supramolecular β-Cyclodextrin/Multi-walled Carbon Nanotube Paste Electrode for Amperometric Detection of Naproxen

Afzali¹,

Rounaghi²,

Zavar³

et al. 2015

J. Electrochem. Soc.

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The electrochemical behavior of Naproxen (NAP) at a novel β-Cyclodextrin/Multi-walled carbon nanotube paste electrode (β-CD/CNTPE) was investigated. The study was carried out by using cyclic voltammetry (CV) and chronoamperometry (CA) techniques. The overall analysis involved an accumulation step, in which the NAP was adsorbed onto β-cyclodextrin, followed by amperometric quantification of NAP. Various parameters such as amount of β-CD, accumulation time, pH and scan rate were optimized. The proposed electrode showed a good response toward NAP determination. The calibration plot for NAP determination is linear in the range of 0.4 to 23 μg mL−1 under optimum experimental conditions. The limit of detection based on 3sb/b was found to be 0.37 μg mL−1. The proposed electrode (β-CD/CNTPE) presented good repeatability, evaluated in term of relative standard deviation (2.7%) for five replicate measurement. Also, the analytical applicability of the proposed electrode was tested through the analysis of several pharmaceutical preparations.

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New Insights on Naproxen Quantification Using Voltammetry and Graphite Electrodes: Development of an Optimized and Competitive Methodology

Cited by 5 publications

References 14 publications

Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products

Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products

Determination of naproxen by using differential pulse voltammetry with poly (aniline-2-sulfonic acid) modified boron doped diamond electrode

Supramolecular β-Cyclodextrin/Multi-walled Carbon Nanotube Paste Electrode for Amperometric Detection of Naproxen

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