New Isoflavones with Antioxidant Activity Isolated from <i>Cornulaca monacantha</i>

Mhiri, Rania; Koubaa, Imed; Chawech, Rachid; Auberon, Florence; Allouche, Noureddine; Michel, Thomas

doi:10.1002/cbdv.202000758

Cited by 12 publications

(6 citation statements)

References 20 publications

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“…The percentages of inhibition were calculated using the following formula: PI% ¼ ½ðAbs blank -Abs sample Þ=Abs blank � � 100 Total antioxidant capacity was determined according to previous method. [15,43] For this assay gallic acid was used as a positive control.3 mL of reagent solution were added to 0.3 mL of extract (0.6 M sulfuric acid, 28 mM sodium phosphate and 4 mM ammonium molybdate). The mixture was placed in a boiling water bath for 90 min; the absorbance was determined at a wavelength of 734 nm.…”

Section: Antioxidant Assaysmentioning

confidence: 99%

“…Antioxidants do not all have the same mode of action, consequently, antioxidant potency must be assessed using multiple methods. [15] In the present research work, the isolates from T. tartonraira were subjected to an in vitro antioxidant activity evaluation using three methods, namely DPPH, Ferric Reducing Antioxidant Power (FRAP) and Total Antioxidant Capacity (TAC) assays. The DPPH assay was conducted to evaluate the ability of the compounds to reduce DPPH * free radical (2,2-diphenyl-1-picrylhydrazyl).…”

Section: Antioxidant Activitymentioning

confidence: 99%

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New Specific α‐Glucosidase Inhibitor Flavonoid from Thymelaea tartonraira Leaves: Structure Elucidation, Biological and Molecular Docking Studies

Soltani

Koubaa

Dhouib

et al. 2023

Chemistry & Biodiversity

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The phytochemical investigation of Thymelaea tartonraira leaves led to the isolation and characterization of six compounds, including one new flavonoid glycoside identified as hypolaetin 8-O-β-D-galactopyranoside (4) along with five known compounds, daphnoretin (1), triumbelletin (2), genkwanin (3), tiliroside (5) and yuankanin (6). Their structures were established based on spectroscopic methods, such as UV, IR, NMR, and HR-ESI-MS. Triumbelletin (2) and tiliroside (5) were isolated for the first time from T. tartonraira leaves. The antioxidant property of all isolated compounds was tested based on DPPH, FRAP and total antioxidant capacity assays. Compound 4 displayed an antioxidant potency more interesting than vitamin C with an IC 50 = 15.00 � 0.50 μg/ ml, followed by compound 5. Furthermore, the both compounds 4 and 5 were tested for their α-amylase inhibitory activity in-vitro. Compound 4 displayed higher potency to inhibit α-amylase, with an IC 50 = 46.49 � 2.32 μg/ml, than compound 5, with an IC 50 = 184.2 � 9.2 μg/ml, while the reference compound acarbose presented the highest potency to inhibit α-amylase with an IC 50 = 0.44 � 0.022 μg/ml. Compound 4 displayed a strong inhibitory ability of α-glucosidase activity approximately twice more than the reference compound, acarbose, with IC 50 values of 60.00 � 3.00 and 125.00 � 6.25 μg/ml, respectively. Thus, compound 4 exhibited a specific inhibitory activity for α-glucosidase. The molecular docking studies have supported our findings and suggested that compound 4 has been involved in various binding interactions within the active site of both enzymes α-amylase and α-glucosidase.

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Section: Antioxidant Assaysmentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

New Specific α‐Glucosidase Inhibitor Flavonoid from Thymelaea tartonraira Leaves: Structure Elucidation, Biological and Molecular Docking Studies

Soltani

Koubaa

Dhouib

et al. 2023

Chemistry & Biodiversity

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“…monacantha Del. is an annual herb growing wild in Egypt, in Arabic known as "Had" and is commonly known as "had and djouri" (Mhiri et al, 2020). The current systematic classification of C. monacantha is listed in Table 1.…”

Section: Introductionmentioning

confidence: 99%

“…Decoction of the leaves is used in folk medicine for treatment of jaundice, also considered as an excellent pasture for camels, especially for its effect on milk production as well as its beneficial purgative effect. It has spiny leaves which used to treat scabies (Mhiri et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Review article on phytochemical constituents and biological activity of Cornulaca monacantha.

Hussien

Badawy

ahmed

et al. 2023

Records of Pharmaceutical and Biomedical Sciences

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Amaranthaceae is a family of flowering plants. It is often containing isoflavonoids. In phytochemical research, various methylene dioxyflavonols, saponins, triterpenoids, ecdysteroids, and specific carbohydrates have been found in the roots. There are around 165 genera and 2,040 species in it. The flowering plant species Cornulaca monacantha is now a member of the Amaranthaceae family and belongs to the genus Cornulaca (formerly Chenopodiaceae). It is a type of desert plant that can be found throughout the Middle East and the Sahara; the southern limit of its distribution is thought to mark the edge of the desert. C. monacantha is an annual herb with thorny leaves that are highly ramified from the base and turn yellow when dried. It has been recognized as an important medicinal plant with different use. The plant is used to cure liver issues including jaundice. It is also regarded as a superior camel pasture, particularly for its impact on milk production. Few studies have been conducted on the chemical composition of C. monacantha, hence little is known about its phytochemical content, including derivatives of quercetin and luteolin, thirteen triterpenoid saponins, four gallotannin analogues, including monacanthin A and monacanthin B. In Arabic it is known as had and djouri, and the Tuareg people call it tahara. It was first described in 1813 by the French botanist Alire Raffeneau Delile.

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“…The in vitro antioxidant and antimicrobial activities of the three extracts were also evaluated. It has been demonstrated that more than one method is necessary to elucidate the antioxidant capacity of samples because these assays differ in the principal and experimental conditions [ 10 , 11 ]. Thus, we used four different complementary antioxidant assays (FRAP, TAC, DPPH, and ABTS) and compared to that of commercial antioxidants such as vitamin C and Trolox.…”

Section: Introductionmentioning

confidence: 99%

ESI-MS/MS Analysis of Phenolic Compounds from Aeonium arboreum Leaf Extracts and Evaluation of their Antioxidant and Antimicrobial Activities

et al. 2021

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Aeonium is a genus of succulents belonging to the Crassulaceae family. Their importance in traditional medicine has stimulated both pharmacological and chemical research. In this study, we optimized extraction, separation, and analytical conditions using a high performance liquid chromatographic method coupled with electrospray ionization mass spectrometry by the negative mode (HPLC-ESI-MS) in order to, for the first time, determine thirty-four compounds from Aeonium arboreum leaves. Twenty-one of them are assigned among which are sixteen flavonoids and five phenolic acids. FRAP, TAC, DPPH, and ABTS•+ radical scavenging were used to evaluate antioxidant activity. The obtained IC50 values ranged from 0.031 to 0.043 mg.mL−1 for DPPH and between 0.048 and 0.09 mg·mL−1 for ABTS•+. Antimicrobial activity was also assessed. The obtained minimum inhibitory concentrations (MIC) of these extracts ranged from 12.5 to 50 µg·mL−1 against Micrococcus luteus, Listeria ivanovii, Staphylococcus aureus, Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger, and Fusarium oxysporum, and from 25 to 50 µg·mL−1 against Candida albicans. Therefore, these extracts can be considered as a potential source of biological active compounds.

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New Isoflavones with Antioxidant Activity Isolated from Cornulaca monacantha

Cited by 12 publications

References 20 publications

New Specific α‐Glucosidase Inhibitor Flavonoid from Thymelaea tartonraira Leaves: Structure Elucidation, Biological and Molecular Docking Studies

New Specific α‐Glucosidase Inhibitor Flavonoid from Thymelaea tartonraira Leaves: Structure Elucidation, Biological and Molecular Docking Studies

Review article on phytochemical constituents and biological activity of Cornulaca monacantha.

ESI-MS/MS Analysis of Phenolic Compounds from Aeonium arboreum Leaf Extracts and Evaluation of their Antioxidant and Antimicrobial Activities

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