New Light in Phototherapy

Vecchi, C; Donzelli, Gianpaolo; Migliorini, Maria Grazia; Sbrana, G.; Pratesi, Riccardo

doi:10.1016/s0140-6736(82)90584-0

Cited by 34 publications

(14 citation statements)

References 10 publications

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“…Therefore one can assume that the most efficient wavelength for phototherapy is close to the green part of the spectrum. Several studies support this (1 [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], but others present arguments against the efficiency of green light based on clinical observations (21,22). The interpretation of clinical data should be done with great care, since not all studies have taken into account the difference in light output from the lamps.…”

Section: Discussionmentioning

confidence: 99%

Cells, bilirubin and light: formation of bilirubin photoproducts and cellular damage at defined wavelengths

et al. 1994

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Cultured cells from one human and one murine cell line were treated with bilirubin and irradiated with visible light of different wavelengths, either from phototherapy lamps or from a Xenon/Mercury lamp equipped with a monochromator. Bilirubin bound to human serum albumin was also irradiated with light. After irradiation, the bilirubin and its photoisomers were extracted and analysed with High Pressure Liquid Chromatography. The formation of single strand breaks in the DNA of treated cells was studied using a fluorescence marker. Cytotoxicity in the mouse skin cell line was measured by loss of the ability to form visible colonies in vitro. Green light exposure favours the production of lumirubin, while blue light causes more DNA damage and cytotoxicity. Green light may be more efficient and safer than shorter wavelength exposure when treating jaundiced newborns with phototherapy.

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Section: Discussionmentioning

confidence: 99%

Cells, bilirubin and light: formation of bilirubin photoproducts and cellular damage at defined wavelengths

et al. 1994

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“…Results for neonates treated with the blue light (BL; 460 nm) indicate that the visible light spectrum range proposed by Cremer [3] is appropriate. But the photo chemistry of Br suggests that a fluorescent green light (GL) [11,12] with a maximal wavelength of 510 nm should be effective. A study of the clinical efficacy of treatment with BL and GL indicated that BL is better for CP [13].…”

mentioning

confidence: 99%

Early Changes in Cutaneous Bilirubin and Serum Bilirubin Isomers during Intensive Phototherapy of Jaundiced Neonates with Blue and Green Light

Myara

Sender²,

Valette³

et al. 1997

Neonatology

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We measured the changes in cutaneous bilirubin (Br) and serum Br photoisomers in two groups of 5 jaundiced newborn infants treated by intensive phototherapy (IP), one with blue light and the other with green light. Cutaneous Br was measured with a transcutaneous jaundice meter and photoisomers were measured by HPLC. Cutaneous Br decreased in the two groups as soon as IP began, and the skin was completely bleached within 3h with blue light only. Rebound occurred which was more marked after blue light IP. The main serum photoproduct was the 4Z-15E isomer, which reached a steady-state level within 1 h in both groups, whereas the lumirubin and 4E-15Z Br concentrations were slightly higher after green light IP. These data indicate that blue light is more suitable for IP, although this is not clearly explained by the production of more lumirubin.

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“…(Although not measured, more bilirubin photooxidation must have also occurred in the infants treated with higher intensity light.) Vecchi and his co-workers have found that fluorescent green light is more effective than broad-spectrum white light in the treatment of neonatal jaundice (21). We have shown that lumirubin concentrations are higher and configurational isomer concentrations are lower in infants treated with green light compared with infants treated with white light (22).…”

Section: Discussionmentioning

confidence: 55%

Rapid clearance of a structural isomer of bilirubin during phototherapy.

Ennever¹,

Costarino²,

Polin³

et al. 1987

J. Clin. Invest.

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During phototherapy for neonatal jaundice, bilirubin is converted into a variety of photoproducts. Determination of the relative importance of these photoproducts to the elimination of bilirubin requires knowledge of their rates of excretion. We have measured the rate at which the structural isomer of bilirubin, lumirubin, disappeared from the serum of nine jaundiced premature infants after the cessation of phototherapy. In all patients studied, the decline in serum lumirubin could be approximated by a firstorder rate equation with a half-life of 80 to 158 min. This rate of disappearance is much faster than that previously determined for the other major bilirubin photoproducts. In samples of bile aspirated from the duodenum of infants undergoing phototherapy, lumirubin was the principal bilirubin photoproduct found. These results indicate that formation and excretion of lumirubin is an important route for bilirubin elimination during phototherapy.

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New Light in Phototherapy

Cited by 34 publications

References 10 publications

Cells, bilirubin and light: formation of bilirubin photoproducts and cellular damage at defined wavelengths

Cells, bilirubin and light: formation of bilirubin photoproducts and cellular damage at defined wavelengths

Early Changes in Cutaneous Bilirubin and Serum Bilirubin Isomers during Intensive Phototherapy of Jaundiced Neonates with Blue and Green Light

Rapid clearance of a structural isomer of bilirubin during phototherapy.

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